Results 211 to 220 of about 292,142 (337)

Prescription of Psychotropic Drugs for Chronic Insomnia in Primary Care

open access: yesJournal of Sleep Research, EarlyView.
ABSTRACT Insomnia is the most prevalent sleep disorder in adults, representing a major public health problem. Healthcare management in a specific area first requires analysing its current practices and issues. We conducted a retrospective observational study of over 100,000 patients from two large primary care databases in the public healthcare ...
Jesús Escribá‐Alepuz   +5 more
wiley   +1 more source

Comparative Pharmacokinetics of Intranasal or Intramuscular Atipamezole in Unsedated Dogs and Efficacy for Reversal of Xylazine Sedation

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The objectives of this study were to evaluate ATIP pharmacokinetics (PK) in healthy Beagle dogs after IM and IN dosing (Phase I), and to compare the rate of reversal of IM versus IN routes for xylazine (XYL) sedation (Phase II). This study was comprised of two sequential, randomized, crossover experiments. The initial PK study dosed ATIP by IN
Vanessa E. Cowan   +7 more
wiley   +1 more source

Exposure to Subcutaneously Administered Butorphanol in Horses Pre‐Treated With Detomidine or Detomidine‐Vatinoxan

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The aim of the study was to determine the exposure to subcutaneously administered butorphanol in horses pre‐treated with intravenous (IV) detomidine, with or without vatinoxan, a peripherally selective alpha2‐adrenoceptor antagonist. Five healthy, adult horses received three IV treatments 7 days apart, in a randomized, cross‐over design ...
Juhana M. Honkavaara   +5 more
wiley   +1 more source

Pharmacokinetics of 2 mg/kg Bupivacaine in a Rectus Abdominis Sheath Block in Horses

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Administering large volumes of bupivacaine in the rectus abdominis sheath (RAS) block in horses could cause local anesthetic toxicity. This study aimed to evaluate the pharmacokinetics of 2 mg/kg bupivacaine in RAS blocks and the associated toxicity risk.
Daniel M. Sakai   +7 more
wiley   +1 more source

Influence of Tramadol on the Intravenous Pharmacokinetics of Dipyrone Active Metabolites in Dogs

open access: yesJournal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study aimed to compare the pharmacokinetic profile of the active dipyrone metabolites 4‐methylaminoantipyrine (MAA) and 4‐aminoantipyrine (AA) administered alone and in combination with tramadol in dogs. Nine mixed‐breed dogs, weighing 15.33 ± 2.25 kg, participated in a two‐treatment crossover design: G1 received intravenous dipyrone (25 ...
Andressa Nunes Mouta   +8 more
wiley   +1 more source

A feasibility study of a co-designed intervention to manage benzodiazepine dependence and high-risk use in those receiving opioid agonist treatment. [PDF]

open access: yesPilot Feasibility Stud
Matheson C   +9 more
europepmc   +1 more source

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