Results 101 to 110 of about 1,267,582 (207)

Irregular visits in longitudinal studies: Comparing inverse intensity of visit weighting and imputation in a causal analysis of antidepressant therapeutic treatment

Canadian Journal of Statistics, EarlyView.
Abstract Irregular observation times are common in longitudinal observational studies and can affect causal inferences. We use data from electronic health records of Kaiser Permanente Washington patients in the United States who initiated an antidepressant medication between 2008 and 2018, with a confirming diagnosis of depression. We are interested in
Janie Coulombe, Erica E. M. Moodie, Susan M. Shortreed   +2 more
wiley   +1 more source

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Murányi Marianna, Szűcs, Mária, Dochnal Roberta, Kicsi Emese, Kicsi, Emese Gabriella, Fábián Gabriella, Szabó Gyula, Szabó, Gyula, Zentai, András, Bozó, Beáta, Fábián, Gabriella, Birkás Erika, Cinar Resat, Bozó Bea, Birkás, Erika, Kékesi Orsolya Sára, Cinar, Resat, Tóth, Géza, Mácsai Mónika, Mácsai, Mónika, Kékesi, Orsolya, Dochnal, Roberta Beatrix, Tóth Géza, Szűcs Mária, Murányi, Marianna, Zentai András   +25 more
core   +1 more source

Five-factor model personality traits in opioid dependence

BMC Psychiatry, 2007
Background Personality traits may form a part of the aetiology of opioid dependence. For instance, opioid dependence may result from self-medication in emotionally unstable individuals, or from experimenting with drugs in sensation seekers.
Nordvik Hilmar, Kornør Hege
doaj   +1 more source

Biography as the Missing Variable in Drug Development: A Case for Bio‐Biographical Mechanistic Profiling

Clinical Pharmacology &Therapeutics, EarlyView.
Most clinical trial failures reflect unmeasured biological heterogeneity. Biography — chronic stress, adversity, trauma, and social isolation—is a neglected source of that heterogeneity, operating through the same molecular pathways drugs engage.
Ralph I. Horwitz
wiley   +1 more source

Intravenous buprenorphine/naloxone and concomitant oral pregabalin misuse: a case report

Neuropsychiatric Disease and Treatment, 2018
Burak Kulaksizoğlu,1,2 Hüseyin Kara,1,2 Berkan Bodur,1,2 Murat Kuloğlu1,2 1Department of Psychiatry, Akdeniz University School of Medicine, Antalya, Turkey; 2Akdeniz University, Alcohol and Substance Addiction Treatment and Research Center, Antalya,
Kulaksizoğlu B, Kara H, Bodur B, Kuloğlu M   +3 more
doaj  

Understanding pregabalin misuse and dependence: Insights from a North Indian addiction treatment center

Indian Journal of Psychiatry
Background: Pregabalin, approved for various medical conditions, has shown increasing misuse potential globally. However, limited research exists on pregabalin dependence in India.
Abhishek Ghosh, Shantanu Shukla, Mondeep Dhankar, Shalini S. Naik, BN Subodh, Debasish Basu   +5 more
doaj   +1 more source

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Clinical Pharmacology &Therapeutics, EarlyView.
Tramadol is frequently co‐prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid‐sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of the multicenter IGNITE ADOPT‐PGx pragmatic trial of patients undergoing ...
Noor A. Nahid, Ahmed I. Soliman, Jordan F. Baye, Natasha J. Petry, Chancellor F. Gray, Rachel A. Myers, Erica N. Elwood, Elizabeth C. Harris, Hrishikesh Chakraborty, Simona Volpi, Renee Rider, Paul R. Dexter, Josh F. Peterson, Todd C. Skaar, Hari K. Parvataneni, Larisa H. Cavallari, Julie A. Johnson, on behalf of the IGNITE Pragmatic Trial Network Investigators, L Orlando, D Voora, C Horowitz, C Horowitz, N Calman, T Skaar, T Skaar, P Dexter, T Skaar, P Dexter, J Johnson, L Cavallari, J Johnson, L Cavallari, J Johnson, L Cavallari, K Blake, K Blake, K Blake, J Peterson, J Peterson, K Cavanaugh, R Singh, R Singh, L Hines, C Wyatt, H Chakraborty, Rishi Chakraborty, Christina Wyatt, Geoff Ginsburg, Kady‐Ann Steen‐Burrell, Bhargav Adagarla, Sarah George, Beth Harris, Jaclyn Holland, Yashika Johnson, Phyllis Kennel, Kristen Linney, Rania Metry, Rachel Myers, Wanda Parker, Gayle Passmore, Carol Pereira, Teji Rakhra‐Burris, Deepak Voora, Ryanne Wu, Teji Rakhra‐Burris, Azita Sadeghpour, Ruth Lehan, Tyffany Locklear, Carol Horowitz, Michelle Ramos, Sabrina Clermont, Bart Ferket, Kenneth Fifer, Diane Hauser, Joseph Kannry, James Murrough, Aniwaa Owusu Obeng, Janet Seo, Tatiana Sabin, Nandini Shroff, Saskia Shuman, Todd Skaar, Paul Dexter, Abi Colwell, Amy Breman, Zeru Desta, Cathy Fulton, Jennelle Hodge, Sheryl Lynch, Jonathan Oliver, Vicky Pratt, Ross Robinson, Elizabeth Rowe, Jennifer Stuart, Emma Tillman, Ashely Vetor, Julie Johnson, Larisa Cavallari, Alexander Parker, Erica Elwood, Kathryn Blake, Emily Cicali, Kelsey Cook, Karam Diaby, Julio Duarte, Ben Duong, Karla Giron, Elizabeth Eddy, Julia Krutov, Carol Mathews, Haesuk Park, Robyn Nelson, Ryan Rhoden, Caroline Schlierle, Taylor Sullivan, Almut Winterstein, Kristen Wiisanen, Josh Peterson, Kerri Cavanaugh, Sara Van Driest, Sara Block, Jordan Baye, Michelle Benck, Chantel Bender, Sylvia Eluhu, Colette Free, Shane Gonnelly, Sarah Hedeen, Lindsay Hines, Steve Houtschilt, Michelle Liu, Salisha Marryshow, Nicole Neville, Natasha Petry, Sidd Pratap, Vernon Sherden, Rajbir Singh, Kimberly Snell. Ana Tomescu, Megan Trietsch, James Walker, Deanna Web, Erin Whiting, Russ Wilke, Simona Volpi, Sarah Hutchison, Natalie Kucher, Ebony Madden, Jessica Reinach, Renee Rider, Ismail Safi, Ella Samer, Lori Orlando, Deepak Voora, Azita Sadeghpour, Lani Banez, Lisa Bendz, Jackie Jordan, Ruth Lehan, Tyffany Locklear, Ann McGee, Christina Nix, Lorraine Vergara, Ryanne Wu, Carol Horowitz, Michelle Ramos, Sabrina Clermont, Tyler Colon, Aaishah Francis, Samantha Guagliardo, Najiba Khan, Camila Tan Lam, Michelle Sciarrino, Emma Maiman‐Stadtmauer, Sofia Medina‐Pardo, Tatiana Sabin, Janet Seo, Lola) Williams, Rishi Chakraborty, Christina Wyatt, Geoff Ginsburg, Sheng Luo, Kady‐Ann Steen‐Burrell, Kevin Anstrom, Bhargav Adagarla, Alicia Ellis, Stephen Ellis, Sarah George, Beth Harris, Jaclyn Holland, Yashika Johnson, Phyllis Kennel, Hwasoon Kim, Kristen Linney, Peter Merrill, Rania Metry, Rachel Myers, Wanda Parker, Gayle Passmore, Carol Pereira, Teji Rakhra‐Burris, Lilin She, Jennifer Shepherd, Saira Siddiqui, Jun Wen, Todd Skaar, Abi Colwell, Brittany Davis, John Howard, Alia Jamison, Lydia Joyner, Ellie Kiihne, Sheryl Lynch, Johnathan Oliver, Ross Robinson, Libbie Silverman, Jordan Sonneville Jennifer Stuart, Laurel Tokar, Ashley Vetor, Neil Calman, Saskia Shuman, Daviana Buck, Nicole Canchucaja Porshia Cook, Ariel Jacobs Danielle John, Samantha Guagliardo, Diane Hauser, Mimi) Milanes, Wambui Ngari, Nandini Shroff, Rajbir Singh, Megan Triestch, Abraham Garcia, Carol Gutierrez, Steven Houtschilt, Maria Lopez, Alan Mejia, Anaite Montes Bu, Deanna Webb, Sonja White, Kathryn Blake, Ben Duong, Taylor Sullivan, Ali Brewer, Kelsey Cook, Brittni Deadrick, Julia Krutov, Lindsay Hines, Jordan Baye, Colette Free, Michelle Benck, Shane Gonnelly, Sarah Hedeen, Alexis Meyer, Blair Svennes, Larisa Cavallari, Erica Elwood, Hana Al Alshaykh, Tala Basha, Emily Cicali, Asia Cobb, Brendon Cooper, Elizabeth Eddy, Amanda Elchynski, Amanda Elsey, Anuksha Gotmare, Karla Giron, Lauren Lemke, Arielle Nelson, Robyn Nelson, Michael Read, Ryan Rhoden, Genevieve Rosier, Isabella Schultz, Chiara Chermont Spina, Joshua Terrell, Alexa Valko, Precious Williams, Tracy Leonard, David Smith, Marian Davis, Vincent Guerra, Jennifer Salo, Claudia Cartaya Torres, Jorge Valedon, Paola Nieves Viana, Alexander Parker, Jose Alonso, Jeffery Gainer, Morgan Howard, Fatoumata Kaba, Brianna Rivers, Liliana Serrano, Kimberly Vigal, ADeia Williams, Josh Peterson, Kerri Cavanaugh, Sara Van Driest, Sara Block, Chantel Bender, Angelo Lazaro, Salisha Merryshow, Nicole Neville, Henry Ong, Erin Whiting   +302 more
wiley   +1 more source

Hepatitis Infection in the Treatment of Opioid Dependence and Abuse

, 2008
Many new and existing cases of viral hepatitis infections are related to injection drug use. Transmission of these infections can result directly from the use of injection equipment that is contaminated with blood containing the hepatitis B or C virus or
Kenneth Hoffman, Diana Sylvestre, Robert Lubran, Thomas F. Kresina, H. Westley Clark, Alain H. Litwin, Leonard Seeff   +6 more
core  

Opioid-Induced Glial Activation: Mechanisms of Activation and Implications for Opioid Analgesia, Dependence, and Reward

The Scientific World Journal, 2007
This review will introduce the concept of toll-like receptor (TLR)–mediated glial activation as central to all of the following: neuropathic pain, compromised acute opioid analgesia, and unwanted opioid side effects (tolerance, dependence, and reward ...
Mark R. Hutchinson, Sondra T. Bland, Kirk W. Johnson, Kenner C. Rice, Steven F. Maier, Linda R. Watkins   +5 more
doaj   +1 more source

Initiation of Gabapentin with Opioids and Risk of Respiratory Cardiovascular and Opioid‐Related Adverse Events Following Surgery for Breast Cancer

Clinical Pharmacology &Therapeutics, EarlyView.
Pain is a key determinant of quality‐of‐life following breast cancer surgery, the most common cancer operation in the United States. Gabapentinoids are frequently prescribed for pain management, yet their respiratory, cardiovascular, and opioid‐related adverse effects remain unclear.
Jyun‐Heng Lai, Anton L V Avanceña, Juan P Cata, Jamie C. Barner, Sharon H. Giordano, Chanhyun Park, Hui Zhao, Kirk E. Evoy, John K. Lin, Jennifer C. Spencer, Mariana Chavez‐MacGregor, Kelly K. Hunt, Kerollos Nashat Wanis   +12 more
wiley   +1 more source