Results 121 to 130 of about 52,732 (301)

Treatment of Opioid Dependence and Overdose

, 2018
Every day in America, 90 individuals die from overdosing on prescription pain relievers or synthetic opioids. From 1999 to 2015, American deaths from opioid drug overdoses increased from 8,048 to 33,091 (National Institute on Drug Abuse, 2017 ...
Jessi Jeffries (10079821)
core   +1 more source

Recreational Drug Use at a Music Festival: A Dual Approach Using Hair Biomarkers Analysis and Participant Self‐Reported Drug Use

Drug Testing and Analysis, EarlyView.
Combined self‐report and hair analysis in festival attendees (n = 249) revealed substantial discrepancies in drug use reporting, particularly for stimulants and dissociatives. This integrated approach enhances detection of poly‐drug use and provides a more reliable basis for monitoring and harm‐reduction strategies.
A. Y. Simão, T. Rosado, M. Barroso, M. Andraus, E. Gallardo   +4 more
wiley   +1 more source

Segmental Hair Analysis of Diphenhydramine and Cyclizine Following a Single Dose

Drug Testing and Analysis, EarlyView.
A single oral dose of diphenhydramine and cyclizine can be quantified in human head hair for a minimum of 5 months and, in certain cases, for up to 1 year following intake. Among 12 study participants, the measured concentrations ranged from 0 to 610 pg/mg within 1 year post‐intake.
Jan Bílek, Marie Katrine Klose Nielsen, Robert Kronstrand, Sys Stybe Johansen   +3 more
wiley   +1 more source

Evidence of CNIH3 involvement in opioid dependence

, 2015
Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data comparing opioid-dependent daily injectors (N ...
Al-Hasani, R., Saccone, N. L., Henders, A. K., Chou, Y. L., Wray, N. R., Gelernter, J., Kapoor, M., Gordon, S., Montgomery, G. W., Nelson, E. C., Wang, T., Bogdan, R., Rice, J. P., Degenhardt, L., Bierut, L. J., Kranzler, H. R., Chou, Y.-L., Wallace, L., Zhang, B., Schwab, S. G., Bruchas, M. R., Carey, C. E., Sherva, R., Todorov, A. A., Zhou, X., Martin, N. G., Conley, E. D., Fakira, A. K., Goate, A., Hesselbrock, V., Farrer, L. A., Moron, J. A., Heath, A. C., Shand, F. L., Lynskey, M. T., Clark, D. J., Agrawal, A., Madden, P. A. F., Madden, P. A F, Demers, C. H., Hariri, A. R.   +40 more
core   +1 more source

Assessment of Abuse Potential‐Related Effects of Oral Dried Kratom Leaf Powder in Healthy Normal Participants Following Single and Multiple Daily Doses

Drug Testing and Analysis, EarlyView.
In a randomized, double‐blind, placebo‐controlled study of oral dried kratom leaf powder in healthy kratom‐naive adults, no participants met the clinically meaningful opioid withdrawal threshold; abuse‐related treatment‐emergent adverse events occurred more frequently at higher doses but were generally mild and resolved without sequelae; and no serious
Marion Coe, Marilyn Huestis, Daniel Wang, Thomas Hudzik, John Bothmer, Jack Henningfield   +5 more
wiley   +1 more source

Tapentadol as a drug of abuse – A preliminary report

Indian Journal of Psychiatry
Background: Tapentadol is a dual action opioid analgesic with emerging data on abuse and diversion. Aim: This study describes tapentadol abuse, clinical presentation, and treatment patterns.
Prakrithi Shivaprakash, Lekhansh Shukla, Sourabh Joshi, Jayant Mahadevan, Arun Kandasamy, Prabhat K. Chand, Vivek Benegal, Pratima Murthy   +7 more
doaj   +1 more source

Office-based opioid dependence treatment

, 2020
Background: Opioid misuse and abuse occurring in association with the treatment of chronic non-cancer pain are not new phenomena, but their increasing prevalence in recent years is unprecedented.
MD Standiford Helm, MD James Colson, MD Sanford Silverman, Dr Colson   +3 more
core  

Evidence of CNIH3 involvement in opioid dependence

, 2016
Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data comparing opioid-dependent daily injectors (N ...
Sherva, R, Hariri, AR, Todorov, AA, Fakira, AK, Bruchas, MR, Zhou, X, Shand, FL, Clark, DJ, Conley, ED, Bogdan, R, Madden, PAF, Rice, JP, Kapoor, M, Kranzler, HR, Nelson, EC, Chou, YL, Wang, T, Montgomery, GW, Goate, A, Bierut, LJ, Degenhardt, L, Henders, AK, Hesselbrock, V, Martin, NG, Carey, CE, Agrawal, A, Gelernter, J, Schwab, SG, Moron, JA, Gordon, S, Farrer, LA, Lynskey, MT, Wallace, L, Zhang, B, Al-Hasani, R, Demers, CH, Saccone, NL, Wray, NR, Heath, AC   +38 more
core   +1 more source

Investigation of the In Vitro and In Vivo Metabolism and μ‐Opioid Receptor Affinity of the Nitazene N‐Pyrrolidino Fluetonitazene

Drug Testing and Analysis, EarlyView.
Eight metabolites for N‐pyrrolidino fluetonitazene were identified in vitro, three of which (M2, M6 and M8) were present in an authentic urine sample. M2 was the most abundant in vivo metabolite and is a common marker metabolite of nitazepyne‐type substances.
Severin Zemp, Gaia Alluisetti, Wolfgang Weinmann, Bettina Schrag, Frank Sporkert, Maurine Leclerc, Katharina Elisabeth Grafinger   +6 more
wiley   +1 more source

Genomewide Linkage Scan for Opioid Dependence and Related Traits

, 2006
Risk of opioid dependence is genetically influenced. We recruited a sample of 393 small nuclear families (including 250 full-sib and 46 half-sib pairs), each with at least one individual with opioid dependence. Subjects underwent a detailed evaluation of
Farrer, Lindsay, Kranzler, Henry R., Panhuysen, Carolien, Rounsaville, Bruce, Sonne, Susan, Gelernter, Joel, Zhao, Hongyu, Poling, James, Weiss, Roger, Wilcox, Marsha, Hesselbrock, Victor   +10 more
core   +1 more source