Results 131 to 140 of about 52,732 (301)

Phase I Metabolism of Novel Phencyclidine Derivative 3‐Cl‐PCP: In Vitro Studies With Pooled Human Liver Microsomes and Investigation of a Post‐Mortem Case

open access: yesDrug Testing and Analysis, EarlyView.
A fatal 3‐chloro‐phencyclidine (3‐Cl‐PCP) intoxication was investigated by analyzing postmortem samples and a pooled human liver microsomes assay. Tentative metabolite identification was performed by liquid chromatography‐quadrupole time‐of‐flight mass spectrometry (LC‐QTOF‐MS). Seven phase I metabolites were identified.
Johannes Kutzler   +3 more
wiley   +1 more source

DEVELOPMENT AND EVALUATION OF A NURSE LEADER-DIRECTED OPIOID STEWARDSHIP INITIATIVE IN A GENERAL PEDIATRIC SETTING

open access: yes
Opioid addiction is a nationwide crisis and one that affects exceptionally vulnerable populations such as adolescents and children. With the rise of the opioid epidemic in the United States, The Joint Commission was prompted to enhance standard ...
Kist, Karen.
core   +1 more source

Maintainence Treatment of Opioid Dependence with Tramadol

open access: yes, 2017
Background: Although tramadol has been used in the management of acute withdrawal in patients with opioid dependence, its use for maintenance treatment as a harm reduction approach has not been assessed systematically. This case series describes patients
Vaibhav Patil   +3 more
core   +1 more source

Dexmedetomidine infusions improve cardiovascular and renal function in anaesthetised, experimentally endotoxaemic horses

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Dexmedetomidine infusions are beneficial in anaesthetised endotoxaemic horses when administered concurrent to endotoxin, but post‐conditioning effects are unknown. Objectives To evaluate whether a dexmedetomidine infusion is beneficial in horses administered Escherichia coli O55:B5 lipopolysaccharides (LPS) endotoxin prior to ...
Sera Lee   +4 more
wiley   +1 more source

Prenatal exposure to buprenorphine or methadone: effects on physical growth, neurological development and temperament in early childhood.

open access: yes, 2012
Pharmaceutical maintenance with methadone is the current gold standard for pregnant women with opioid-dependence. While there are many benefits of methadone, its use during pregnancy is associated with high rates of neonatal abstinence syndrome, and long
Whitham, Justine N.
core  

Fatalities within seven days after equine standing sedation: A prospective, multicentre study

open access: yesEquine Veterinary Journal, EarlyView.
Abstract Background Information regarding mortality associated with standing procedures in horses is sparse. Objectives To report data from >12,000 standing sedations. Study Design Confidential, observational, prospective, multicentre, cohort study.
Miguel Gozalo‐Marcilla   +6 more
wiley   +1 more source

Rewiring nutrition: Chemical insights into the physiological and microbiological roles of food's microconstituents

open access: yesFood Biomacromolecules, EarlyView.
Bidirectional interactions between food‐derived sensory compounds, gut sensing and microbiota, host physiological feedback, and metabolite production within the food matrix collectively shape sensory perception, microbial dynamics, and metabolic health.
Mohammad Nazrul Islam Bhuiyan
wiley   +1 more source

Sustained-release naltrexone: novel treatment for opioid dependence

open access: yes, 2007
The devastating costs of opioid abuse and dependence underscore theneed for effective treatments for these disorders. At present, several different maintenance medications exist for treating opioid dependence, including methadone, buprenorphine and ...
Comer, Sandra D.   +2 more
core   +1 more source

Opioid misuse.

open access: yes, 2010
PHARMACOLOGY OF OPIOIDS: The term ‘opioids’ refers to a class of psychoactive substances derived from the poppy plant (including opium, morphine and codeine), as well as semi-synthetic forms (including heroin) and synthetic compounds (including ...
Pinjon, Emmanuelle
core  

Negative affect, pain and sex: The role of endogenous opioids

open access: yes, 2007
Opioid neurotransmission modulates pain and negative affect during psychological stress. To determine whether these effects differ between men and women, the opioid receptor antagonist naltrexone or placebo was administered double-blind to 21 men and 22 ...
Frew, A.K., Drummond, P.D.
core  

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