Results 111 to 120 of about 52,732 (301)

Advances in the delivery of buprenorphine for opioid dependence

, 2017
Richard N Rosenthal,1 Viral V Goradia2 1Department of Psychiatry, Addiction Institute at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, 2Department of Psychiatry, Upstate Medical University, Syracuse, NY, USA Abstract: Opioid use ...
Rosenthal RN, Goradia VV
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Baclofen for maintenance treatment of opioid dependence: A randomized double-blind placebo-controlled clinical trial [ISRCTN32121581]

BMC Psychiatry, 2003
Background Results of preclinical studies suggest that the GABAB receptor agonist baclofen may be useful in treatment of opioid dependence. This study was aimed at assessing the possible efficacy of baclofen for maintenance treatment of opioid dependence.
Ahmadi-Abhari Seyed Ali, Radgoodarzi Reza, Assadi Seyed Mohammad   +2 more
doaj   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

Clinical Pharmacology &Therapeutics, EarlyView.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix, Sam Mostafa, Amin Rostami‐Hodjegan, Thomas M. Polasek, Carl M. J. Kirkpatrick   +4 more
wiley   +1 more source

Understanding pregabalin misuse and dependence: Insights from a North Indian addiction treatment center

Indian Journal of Psychiatry
Background: Pregabalin, approved for various medical conditions, has shown increasing misuse potential globally. However, limited research exists on pregabalin dependence in India.
Abhishek Ghosh, Shantanu Shukla, Mondeep Dhankar, Shalini S. Naik, BN Subodh, Debasish Basu   +5 more
doaj   +1 more source

Brain opioid receptor binding in early abstinence from opioid dependence: Positron emission tomography study

, 2007
Background Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood.
Lingford-Hughes, Anne, Grasby, Paul, Daglish, Mark, Taylor, LG, Nutt, David J., Myles, JS, Brooks, DJ, Brooks, David J., Lingford-Hughes, AR, Daglish, MRC, Williams, Tim M., Hammers, Alexander, Daglish, Mark R. C., Hammers, A, Myles, Judith S., Williams, TM, Hammers, Alexander; id_orcid, Taylor, Lindsay G., Nutt, DJ, Grasby, P   +19 more
core   +1 more source

Population Genomics Insights into Pharmacogenomic Differentiation Between East Asians and Europeans

Clinical Pharmacology &Therapeutics, EarlyView.
Genetic variation contributes substantially to interindividual and interpopulation differences in drug response, yet most pharmacogenomic studies remain biased toward European populations. Here, we systematically assessed pharmacogenomic variation across East Asians (EAS) and Europeans (EUR) using public genomic datasets and investigated the potential ...
Sihan Chen, Hongpu Chen, Shuhua Xu
wiley   +1 more source

Molecular and cellular basis of mu-opioid receptor signaling: mechanisms underlying tolerance and dependence development

Frontiers in Neuroscience
Opioids, while highly effective for pain management, are among the most addictive substances, contributing significantly to the global opioid crisis.
Michael Swingler, Martina Donadoni, Ellen M. Unterwald, Sanjay B. Maggirwar, Ilker K. Sariyer   +4 more
doaj   +1 more source

Safety and tolerability of slow-release oral morphine versus methadone in the treatment of opioid dependence

, 2014
Opioid substitution treatment (OST) for opioid dependence may be limited by adverse events (AEs). Increasing the range of therapeutic options optimizes outcomes and facilitates patient management.
Hämmig, Robert, Verthein, Uwe, Haasen, Christian, Reimer, Jens, Vollmert, Christian, Gholami, Najibulah, Babic-Hohnjec, Lucija, Weber, Bernd, Bonorden-Kleij, Karin, Köhler, Wilfried, Ruckes, Christian, Berthel, Toni, Höpner, Doris, Lebentrau, Karin   +13 more
core   +1 more source

Identification and Characterization of the Designer Opioid N‐Pyrrolidino Fluetonitazene in Nasal Spray

Drug Testing and Analysis, EarlyView.
N‐Pyrrolidino fluetonitazene, a synthetic opioid, was identified and characterized in a nasal spray using GC‐MS, LC‐QTOF‐MS, NMR and FT‐IR. ABSTRACT Detection of drugs in non‐biological samples serves as a fundamental basis for identifying emerging trends in the field of new psychoactive substances and provides valuable information for optimizing ...
Fabian Picht, Valentin Cepus, Rona Hohlfeld, Julian Klingbeil, Marco Weber   +4 more
wiley   +1 more source

Social trauma and the mu-opioid system in depression

, 2011
The overarching thesis under investigation is that the endogenous opioid system plays a key role in depression subsequent to traumatic childhood social experiences. This is suggested by the fact that animal work indicates that mu-opioids robustly mediate
Malcolm-Smith, Susan
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