Results 71 to 80 of about 1,267,582 (207)

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Medication-assisted treatment of opioid dependence information toolkit. [PDF]

, 2015
This information kit developed by researchers at the National Drug and Alcohol Research Centre at UNSW provides a step by step guide to the evidence for medically assisted treatment for heroin dependence as well as answering commonly asked questions ...
Dolan, Kate, Mehrjerdi, Zahra Alam
core  

Cerebrospinal Fluid Cytokine Expression and Relationships With Neurological Measures in Virologically Controlled People With HIV

Annals of Neurology, EarlyView.
Objective Quantify cytokines in cerebrospinal fluid (CSF) of virologically suppressed people with HIV (PWH) and people without HIV (PWoH) and correlate these with neuroimaging, neuropsychometric (NP), and neurodegenerative measurements. Methods CSF samples were collected from virologically suppressed PWH and demographically matched PWoH under a natural
Jack Peterson, Clarissa Xia, Govind Nair, Joseph Snow, Julia Stone, Gina Norato, Brandon Do, Samuel Darko, Kory Johnson, Swati Shah, Amanda Wiebold, Melina Jones, Avindra Nath, Darshan Pandya   +13 more
wiley   +1 more source

Brain opioid receptor binding in early abstinence from opioid dependence: Positron emission tomography study

, 2007
Background Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood.
Lingford-Hughes, Anne, Grasby, Paul, Daglish, Mark, Taylor, LG, Nutt, David J., Myles, JS, Brooks, DJ, Brooks, David J., Lingford-Hughes, AR, Daglish, MRC, Williams, Tim M., Hammers, Alexander, Daglish, Mark R. C., Hammers, A, Myles, Judith S., Williams, TM, Hammers, Alexander; id_orcid, Taylor, Lindsay G., Nutt, DJ, Grasby, P   +19 more
core   +1 more source

Online collection of meeting minutes of the Kansas Prescription Drug and Opioid Advisory Committee's committees, subcommittees and other afiliated groups, 2015-2018.

, 2015
Kansas Prescription Drug and Opioid Advisory Committee and subcommittees and other groups: Diagrams (2 pages) Kansas Prescription Drug and Opioid Advisory Committee.
Kansas Prescription Drug and Opioid Advisory Committee
core   +1 more source

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Evidence of CNIH3 involvement in opioid dependence

, 2015
Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data comparing opioid-dependent daily injectors (N ...
Al-Hasani, R., Saccone, N. L., Henders, A. K., Chou, Y. L., Wray, N. R., Gelernter, J., Kapoor, M., Gordon, S., Montgomery, G. W., Nelson, E. C., Wang, T., Bogdan, R., Rice, J. P., Degenhardt, L., Bierut, L. J., Kranzler, H. R., Chou, Y.-L., Wallace, L., Zhang, B., Schwab, S. G., Bruchas, M. R., Carey, C. E., Sherva, R., Todorov, A. A., Zhou, X., Martin, N. G., Conley, E. D., Fakira, A. K., Goate, A., Hesselbrock, V., Farrer, L. A., Moron, J. A., Heath, A. C., Shand, F. L., Lynskey, M. T., Clark, D. J., Agrawal, A., Madden, P. A. F., Madden, P. A F, Demers, C. H., Hariri, A. R.   +40 more
core   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Evidence of CNIH3 involvement in opioid dependence

, 2016
Opioid dependence, a severe addictive disorder and major societal problem, has been demonstrated to be moderately heritable. We conducted a genome-wide association study in Comorbidity and Trauma Study data comparing opioid-dependent daily injectors (N ...
Sherva, R, Hariri, AR, Todorov, AA, Fakira, AK, Bruchas, MR, Zhou, X, Shand, FL, Clark, DJ, Conley, ED, Bogdan, R, Madden, PAF, Rice, JP, Kapoor, M, Kranzler, HR, Nelson, EC, Chou, YL, Wang, T, Montgomery, GW, Goate, A, Bierut, LJ, Degenhardt, L, Henders, AK, Hesselbrock, V, Martin, NG, Carey, CE, Agrawal, A, Gelernter, J, Schwab, SG, Moron, JA, Gordon, S, Farrer, LA, Lynskey, MT, Wallace, L, Zhang, B, Al-Hasani, R, Demers, CH, Saccone, NL, Wray, NR, Heath, AC   +38 more
core   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source