Results 51 to 60 of about 1,267,582 (207)
Use of buprenorphine/naloxone combination for the treatment of opioid dependence: Antalya sample
Psychiatry and Clinical Psychopharmacology, 2021 Objective: In this study, retrospective investigation of the effects of the sociodemographic attributes in opiate dependents on Buprenorphine/Naloxone combination and symptomatic medication treatments is aimed.
F Mükerrem Güven +3 more
doaj
Addictive Behaviors Reports, 2018 Introduction: People with chronic opioid use disorder often present to treatment with individual and structural vulnerabilities and remain at risk of reporting adverse health outcomes.
Heather Palis +12 more
doaj +1 more source
Innovative Approach Reveals How Receptors Control G Protein State Equilibria
Advanced Science, EarlyView.Using conformational specific trFRET biosensors of the Gi protein (depicted at the bottom), the authors show that receptor activation can not only release GDP from the inactive G protein, but can also release GTP from the activated G protein, leading to the reformation of the RG ternary complex.
Alexandre Bouyssou +12 more
wiley +1 more source
Pharmacogenomics and Personalized Medicine, 2009 Janet K Coller1, Julia Beardsley1, James Bignold1, Yibai Li1, Florence Merg1, et al1Discipline of Pharmacology, School of Medical Sciences; 2Discipline of Public Health, School of Population Health and Clinical Practice; 3School of Biomedical and ...
Janet K Coller +5 more
doaj
qcGEM: A Graph‐Based Molecular Representation With Quantum Chemistry Awareness
Advanced Science, EarlyView.In this work, we introduce qcGEM, a quantum‐chemistry‐aware graph‐based embedding of molecules that incorporates physical priors into molecular representation learning. Through a specially designed model architecture to adequately process quantum chemistry information as well as three‐dimensional molecular geometry, qcGEM provides a compact, physics ...
Haoyu Wang +3 more
wiley +1 more source
Contemporary management of pain in cirrhosis: Toward precision therapy for pain
Hepatology, EarlyView., 2022 Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman +4 more
wiley +1 more source
Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2016 Modern narcology demonstrates a problem of insufficient effectiveness of pharmacotherapy for stabilization of remission in patients with opioid dependence.
V. Ya. Palatkin +4 more
doaj +1 more source
Advanced Science, EarlyView.Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng +7 more
wiley +1 more source
Stress-evoked opioid release inhibits pain in major depressive disorder [PDF]
, 2008 To determine whether stress-evoked release of endogenous opioids might account for hypoalgesia in major depressive disorder (MDD), the μ-opioid antagonist naltrexone (50 mg) or placebo was administered double-blind to 24 participants with MDD and to 31 ...
Frew, A.K., Drummond, P.D.
core
Buprenorphine in the treatment of opioid dependence
, 2007 Methadone has been the mainstay of pharmacological management of opioid dependence since the 1960s but buprenorphine is fast gaining acceptance among addiction specialists and patients. This article provides an overview of buprenorphine, its pharmacology,
Day, Edward; id_orcid, George, S
core +4 more sources