Results 51 to 60 of about 52,732 (301)

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Use of buprenorphine/naloxone combination for the treatment of opioid dependence: Antalya sample

Psychiatry and Clinical Psychopharmacology, 2021
Objective: In this study, retrospective investigation of the effects of the sociodemographic attributes in opiate dependents on Buprenorphine/Naloxone combination and symptomatic medication treatments is aimed.
F Mükerrem Güven, Hacer Yalniz, Melike Nebioğlu, Ömer Geçici   +3 more
doaj  

The association between nicotine dependence and physical health among people receiving injectable diacetylmorphine or hydromorphone for the treatment of chronic opioid use disorder

Addictive Behaviors Reports, 2018
Introduction: People with chronic opioid use disorder often present to treatment with individual and structural vulnerabilities and remain at risk of reporting adverse health outcomes.
Heather Palis, Kirsten Marchand, Mohammad Karamouzian, Scott MacDonald, Scott Harrison, Daphne Guh, Kurt Lock, Suzanne Brissette, Aslam H. Anis, Michael Krausz, David C. Marsh, Martin T. Schechter, Eugenia Oviedo-Joekes   +12 more
doaj   +1 more source

Longitudinal Phenotypic Trajectories in GNAO1‐Related Disorders: Defining Disease Progression and Clinical Profiles

Annals of Neurology, EarlyView.
Objective Pathogenic variants in GNAO1 cause a spectrum of epilepsy, movement disorders, and developmental impairment. Clinical heterogeneity complicates prognosis and therapeutic development. We present the first longitudinal natural history study of GNAO1‐related disorders (GNAO1‐RD) to delineate phenotypic trajectories. Methods Sixty‐six individuals
Jana Domínguez‐Carral, Ana María Domínguez Cobo, Sol Balsells, Anna Aguilar‐Ros, Chu‐Ting Chang, William G. Ludlam, Kathryn Yang, Katerina Bernardi, Micaela Chinigioli, Ainara Salazar‐Villacorta, Veronica Di Pisa, Nuria Lamagrande‐Casanova, Elena González‐Alguacil, Beatriz De la Casa‐Fages, Akihisa Okumura, Josefina Rodríguez, Ayush Agarwal, Daniela Muñoz‐Chesta, Carolina Reynoso‐Osnayo, Amy Lin, Brahim Tabarki, Jobaida Parvin, Adolfo Alberto Gallo, Andreia Forno, Fabian Maass, Johnny Montiel Blanco, Salomé Nasif, Elizabeth Jennions, Jorge Luis Ramón‐Gómez, Helene Verhelst, Juan José Nieto Barceló, Dunja Čokolić Petrović, Luz Victoria García Ruiz, Christoph van Riesen, Paulo Rego Sousa, Maria del Pilar Massaro Sanchez, Husnea Ara Khan, Wejdan Hakami, Jennifer Friedman, Iván Espinoza‐Quinteros, Monica Troncoso, Divyani Garg, Micaela Pauni, Hirokazu Kurahashi, María Concepción Miranda‐Herrero, Anna Duat‐Rodriguez, Luca Soliani, Manju A. Kurian, Angeles Schteinschnaider, Siddharth Srivastava, Darius Ebrahimi‐Fakhari, Kirill A. Martemyanov, Juan Darío Ortigoza‐Escobar   +52 more
wiley   +1 more source

Fentanyl dependence caused by the non-medical use: a case report

Psychiatry and Clinical Psychopharmacology, 2021
Fentanyl is a pure and selective μ opioid receptor agonist. Its analgesic potency is 80-800 times greater than that of morphine with fewer adverse effects. Available formulations of fentanyl patches in Turkey contain 1.25, 2.5, 5, and 7.5 mg or 10 mg of
Omer Gecici, Zehra Gokmen, Melike Nebioglu   +2 more
doaj  

Stabilization of remission in patients with opioid depen dence: pharmacological and pharmacogenetic aspects

Учёные записки Санкт-Петербургского государственного медицинского университета им. Акад. И.П. Павлова, 2016
Modern narcology demonstrates a problem of insufficient effectiveness of pharmacotherapy for stabilization of remission in patients with opioid dependence.
V. Ya. Palatkin, A. O. Kibitov, E. A. Blokhina, E. M. Krupitsky, E. E. Zvartau   +4 more
doaj   +1 more source

Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in Blood–Brain Barrier Endothelial Cells by Disrupting the Regulation of Transferrin Receptors

Annals of Neurology, EarlyView.
Model figure of BBBECs TfR1 regulation in control and RLS: Graphical representation of TfR1 regulation in ECs by IRPs and representing it can be dysregulated by miR‐124‐3p in ECs of RLS. FPN1, ferroportin; BBBEC, blood‐brain barrier endothelial cells; IRP, iron regulatory proytein1/2; TfR1, Transferrin receptor; IRE, Iron responsive elements; Tf ...
Kondaiah Palsa, Aurosman Pappus Sahu, David B. Rye, Lynn Marie Trotti, Irina A. Elcheva, Vladimir S. Spiegelman, James R. Connor   +6 more
wiley   +1 more source

Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid  dependence: A meta-analysis

Pharmacogenomics and Personalized Medicine, 2009
Janet K Coller1, Julia Beardsley1, James Bignold1, Yibai Li1, Florence Merg1, et al1Discipline of Pharmacology, School of Medical Sciences; 2Discipline of Public Health, School of Population Health and Clinical Practice; 3School of Biomedical and ...
Janet K Coller, Julia Beardsley, James Bignold, Yibai Li, Florence Merg, et al   +5 more
doaj  

Long-Acting Injectable naltrexone for the Management of patients with Opioid Dependence

Substance Abuse: Research and Treatment, 2011
Opioid dependence is a condition with serious clinical ramifications. Treatment has focused on detoxification, agonist therapy with methadone or buprenorphine, or remission maintenance with the opioid antagonist, naltrexone.
Kimberly L. Kjome, F. Gerard Moeller
doaj   +1 more source

Possible Involvement of Endogenous Opioid System Located Downstream of α7 Nicotinic Acetylcholine Receptor in Mice With Physical Dependence on Nicotine

Journal of Pharmacological Sciences, 2014
.: We previously reported that nicotine (NIC)-induced analgesia was elicited in part by activation of the endogenous opioid system. Moreover, it is well known that NIC has physical-dependence liability, but its mechanism is unclear.
Keiko Ueno, Norikazu Kiguchi, Yuka Kobayashi, Fumihiro Saika, Naoki Wakida, Chizuko Yamamoto, Takehiko Maeda, Masanobu Ozaki, Shiroh Kishioka   +8 more
doaj   +1 more source