Results 41 to 50 of about 1,267,582 (207)

Creating opioid dependence in the emergency department

, 2017
Clinical questionWhat is the risk of creating opioid dependence from an ED opioid prescription?Article chosenBarnett ML, Olenski AR, Jena AB. Opioid-prescribing patterns of emergency physicians and risk of long-term use. N Engl J Med 2017;376:663-73, doi:
Suneel Upadhye
core   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

Preoperative Opioid Dependence Associated with Increased Costs and Wound Dehiscence Following Total Ankle Arthroplasty

Foot & Ankle Orthopaedics
Category: Ankle; Ankle Arthritis Introduction/Purpose: The overuse of opioid medications in patients undergoing orthopaedic surgery has become widely labeled as a national epidemic.
Weston E. McDonald BS, Alexander S. Guareshi BS, Joshua L. Morningstar BS, Richard J. Friedman MD, FRCSC, Christopher E. Gross MD, Daniel J. Scott MBA, MD   +5 more
doaj   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Introduction to the College on Problems of Drug Dependence Special Issue: Contemporary Advances in Opioid Neuropharmacology

, 2010
Opioid receptors are critical therapeutic targets for medications development relevant to the treatment of drug dependence and pain. With recent advances in molecular neurobiology, it has become evident that the functional activity of opioid receptors ...
Walsh, Sharon L, Unterwald, Ellen M, Izenwasser, Sari   +2 more
core   +1 more source

Sustained release naltrexone for opioid dependence: : Effectiveness, safety, and clinical feasibility [PDF]

, 2010
The current standard for clinical treatment of dependence on heroin and other opioids is to maintain the dependence with slower-acting opioids like methadone or buprenorphine.
Kunøe, Nikolaj
core   +1 more source

Fentanyl dependence caused by the non-medical use: a case report

Psychiatry and Clinical Psychopharmacology, 2021
Fentanyl is a pure and selective μ opioid receptor agonist. Its analgesic potency is 80-800 times greater than that of morphine with fewer adverse effects. Available formulations of fentanyl patches in Turkey contain 1.25, 2.5, 5, and 7.5 mg or 10 mg of
Omer Gecici, Zehra Gokmen, Melike Nebioglu   +2 more
doaj  

2327

Journal of Clinical and Translational Science, 2017
OBJECTIVES/SPECIFIC AIMS: Dependence and abuse of prescription opioid pain medication has substantially increased over the last decade. The consistent rise in opioid dependence contributes to the rising prescription drug overdose deaths over the last ...
Shyamashree Sinha, Gale Burstein, Kenneth E. Leonard, Timothy Murphy, Peter Elkin   +4 more
doaj   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source