Results 21 to 30 of about 52,732 (301)

Epidemiological evidence on extra-medical use of prescription pain relievers: transitions from newly incident use to dependence among 12–21 year olds in the United States using meta-analysis, 2002–13 [PDF]

PeerJ, 2015
Background. When 12-to-21-year-olds start using prescription pain relievers extra-medically, some of them transition into opioid dependence within 12 months after such use.
Maria A. Parker, James C. Anthony
doaj   +2 more sources

Can patient and fracture factors predict opioid dependence following upper extremity fractures?: a retrospective review

Journal of Orthopaedic Surgery and Research, 2019
Background Since the early 1990s, opioids have been used as a mainstay for pain management surrounding fracture injuries. As opioid dependence has become a major public health issue, it is important to understand what factors can leave patients ...
Vani Janaki Sabesan, Kiran Chatha, Lucas Goss, Claudia Ghisa, Gregory Gilot   +4 more
doaj   +1 more source

Variability of response to pharmacotherapy of naltrexone and guanfacin in patients with opioid dependence syndrome: pharmacogenetic aspect

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
There is a problem of insufficient effectiveness of pharmacotherapy for the relapse prevention in patients with opioid dependence. In Russian Federation naltrexone is a mainly used medication for treatment of opioid addiction.
V. Ya Palatkin, A. O. Kibitov, Е. M. Krupitsky, Е. A. Blokhina Е.A., V. M Brodyansky, Е. V. Verbitskaya, E. E. Zvartau   +6 more
doaj   +1 more source

A computational strategy for finding novel targets and therapeutic compounds for opioid dependence.

PLoS ONE, 2018
Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use of opioid can also cause tolerance, dependence, and even
Xiaojun Wu, Siwei Xie, Lirong Wang, Peihao Fan, Songwei Ge, Xiang-Qun Xie, Wei Wu   +6 more
doaj   +1 more source

Stress reactivity in heroin dependence [PDF]

, 2015
Background: Heroin dependence is a chronic relapsing disorder characterized by a compulsion to seek and use heroin despite the negative consequences. In addition to the diagnostic criteria, heroin dependence is associated with an altered function of the ...
Gerber, Hana
core   +1 more source

Application of risk assessment tools to predict opioid usage after shoulder surgery

JSES International, 2022
Background: Currently 128 people die daily from opioid-related overdoses in the United States. This burden has instigated a search for viable means to guide postoperative prescription decision-making.
Laila H. Khoury, BS, Josh Stephens, BS, Shimron Brown, BS, Kiran Chatha, MD, Sarah Girshfeld, BA, Juan Manuel Lozano Leon, MD, MSc, Alessia Lavin, MD, Vani J. Sabesan, MD   +7 more
doaj   +1 more source

Reduced Narcotic Utilization in Total Joint Arthroplasty Patients in an Urban Tertiary Care Center

Arthroplasty Today, 2022
Background: Opioid use after total joint arthroplasty must be balanced against the risks of opioid dependence and diversion. This study sought to define the baseline patient characteristics and discharge opioid use after the initiation of a preoperative ...
Brandon Lentine, MD, Hassan Beesley, MD, Quinten Dicken, MD, Ruijia Niu, MPH, David M. Freccero, MD, Eric L. Smith, MD   +5 more
doaj   +1 more source

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Murányi Marianna, Szűcs, Mária, Dochnal Roberta, Kicsi Emese, Kicsi, Emese Gabriella, Fábián Gabriella, Szabó Gyula, Szabó, Gyula, Zentai, András, Bozó, Beáta, Fábián, Gabriella, Birkás Erika, Cinar Resat, Bozó Bea, Birkás, Erika, Kékesi Orsolya Sára, Cinar, Resat, Tóth, Géza, Mácsai Mónika, Mácsai, Mónika, Kékesi, Orsolya, Dochnal, Roberta Beatrix, Tóth Géza, Szűcs Mária, Murányi, Marianna, Zentai András   +25 more
core   +1 more source

Inhibition of activity of GABA transporter GAT1 by δ-opioid receptor [PDF]

, 2012
Analgesia is a well-documented effect of acupuncture. A critical role in pain sensation plays the nervous system, including the GABAergic system and opioid receptor (OR) activation.
Fucke, Thomas, Schwarz, Wolfgang, Xu, Nanjie, Pu, Lu, Pei, Gang, Gu, Quanbao, Xia, Peng, Ren, Shuanglai   +7 more
core   +1 more source

Hallucination with Tapering Dose of Buprenorphine [PDF]

Journal of Clinical and Diagnostic Research, 2020
Opioid dependence is one of the most common types of drug dependence in India which requires pharmacological intervention. Buprenorphine is one of the commonly prescribed drugs in Opioid Substitution Therapy (OST).
Poonam Bharti, Tanujveer Singh Chandok, Chahat Sahoonja, Sana Usmani   +3 more
doaj   +1 more source