Results 21 to 30 of about 1,267,582 (207)

Variability of response to pharmacotherapy of naltrexone and guanfacin in patients with opioid dependence syndrome: pharmacogenetic aspect

Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2019
There is a problem of insufficient effectiveness of pharmacotherapy for the relapse prevention in patients with opioid dependence. In Russian Federation naltrexone is a mainly used medication for treatment of opioid addiction.
V. Ya Palatkin, A. O. Kibitov, Е. M. Krupitsky, Е. A. Blokhina Е.A., V. M Brodyansky, Е. V. Verbitskaya, E. E. Zvartau   +6 more
doaj   +1 more source

A computational strategy for finding novel targets and therapeutic compounds for opioid dependence.

PLoS ONE, 2018
Opioids are widely used for treating different types of pains, but overuse and abuse of prescription opioids have led to opioid epidemic in the United States. Besides analgesic effects, chronic use of opioid can also cause tolerance, dependence, and even
Xiaojun Wu, Siwei Xie, Lirong Wang, Peihao Fan, Songwei Ge, Xiang-Qun Xie, Wei Wu   +6 more
doaj   +1 more source

Stress reactivity in heroin dependence [PDF]

, 2015
Background: Heroin dependence is a chronic relapsing disorder characterized by a compulsion to seek and use heroin despite the negative consequences. In addition to the diagnostic criteria, heroin dependence is associated with an altered function of the ...
Gerber, Hana
core   +1 more source

Application of risk assessment tools to predict opioid usage after shoulder surgery

JSES International, 2022
Background: Currently 128 people die daily from opioid-related overdoses in the United States. This burden has instigated a search for viable means to guide postoperative prescription decision-making.
Laila H. Khoury, BS, Josh Stephens, BS, Shimron Brown, BS, Kiran Chatha, MD, Sarah Girshfeld, BA, Juan Manuel Lozano Leon, MD, MSc, Alessia Lavin, MD, Vani J. Sabesan, MD   +7 more
doaj   +1 more source

Reduced Narcotic Utilization in Total Joint Arthroplasty Patients in an Urban Tertiary Care Center

Arthroplasty Today, 2022
Background: Opioid use after total joint arthroplasty must be balanced against the risks of opioid dependence and diversion. This study sought to define the baseline patient characteristics and discharge opioid use after the initiation of a preoperative ...
Brandon Lentine, MD, Hassan Beesley, MD, Quinten Dicken, MD, Ruijia Niu, MPH, David M. Freccero, MD, Eric L. Smith, MD   +5 more
doaj   +1 more source

Variants of opioid system genes are associated with non-dependent opioid use and heroin dependence

, 2016
Heroin addiction is a chronic, relapsing brain disease. Genetic factors are involved in the development of drug addiction. The aim of this study was to determine whether specific variants in genes of the opioid system are associated with non-dependent ...
van Ree, Jan M., Kreek, Mary Jeanne, Levran, Orna, da Rosa, Joel Correa, Ott, Jurg, van den Brink, Wim, Yuferov, Vadim, Blanken, Peter, Butelman, Eduardo R., Randesi, Matthew, van Ree, Jan M, Butelman, Eduardo R, Brain, Translational Neuroscience   +13 more
core   +1 more source

The Need for Psychosocial Interventions to Facilitate the Transition to Extended-Release Naltrexone (XR-NTX) Treatment for Opioid Dependence: A Concise Review of the Literature

Substance Abuse: Research and Treatment, 2016
Given the increase of opioid dependence and opioid-related morbidity and mortality, improving treatment options for individuals with opioid dependence warrants increased attention. This article provides a concise review of work in this area.
Susan E. Ramsey, Dan Rounsaville, Randall Hoskinson, Tae Woo Park, Evan G. Ames, Victor D. Neirinckx, Peter Friedmann   +6 more
doaj   +1 more source

Hallucination with Tapering Dose of Buprenorphine [PDF]

Journal of Clinical and Diagnostic Research, 2020
Opioid dependence is one of the most common types of drug dependence in India which requires pharmacological intervention. Buprenorphine is one of the commonly prescribed drugs in Opioid Substitution Therapy (OST).
Poonam Bharti, Tanujveer Singh Chandok, Chahat Sahoonja, Sana Usmani   +3 more
doaj   +1 more source

Opioid Dependence in Schizophrenia: Understanding the Co-occurrence and Implications [PDF]

Opioid dependence is a serious concern in individuals with schizophrenia, as the co-occurrence of these 2 conditions presents unique challenges in diagnosis, treatment, and recovery.
Díaz-Moreno, Emilio, Altable, MArcos, De la Serna, Juan Moises, Akram, Muhammad   +3 more
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source