Results 11 to 20 of about 1,267,582 (207)
Molecules, 2020 Opioid analgesics are effective pain therapeutics but they cause various adverse effects and addiction. For safer pain therapy, biased opioid agonists selectively target distinct μ opioid receptor (MOR) conformations, while the potential of biased opioid
Wolfgang Sadee +2 more
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Relapse in opioid dependence: Role of psychosocial factors
Indian Journal of Psychiatry, 2021 Background: Although our understanding about neurobiology of opioid dependence and availability of pharmacological treatment has gone a long way in the last few decades, psychosocial interventions play a pivotal role in the prevention of relapse owing to
Kailash Sureshkumar +3 more
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Dopamine D1 receptor gene variation modulates opioid dependence risk by affecting transition to addiction. [PDF]
PLoS ONE, 2013 Dopamine D1 receptor (DRD1) modulates opioid reinforcement, reward, and opioid-induced neuroadaptation. We propose that DRD1 polymorphism affects susceptibility to opioid dependence (OD), the efficiency of transition to OD, and opioid-induced pleasure ...
Feng Zhu +9 more
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Indian Journal of Psychological Medicine, 2020 Background: The relationship between the level of motivation and personality disorder (PD) in patients with opioid dependence syndrome is understudied.
Manu Sharma +3 more
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International Journal of Population Data Science, 2022 Background As dispensings for benzodiazepines and gabapentinoids have increased in recent years, risk of increased mortality has been identified, particularly when used with opioids. There is limited research examining use of these medicines among people
Chrianna Bharat +6 more
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Foot & Ankle Orthopaedics, 2020 Category: Other Introduction/Purpose: Surgeon prescription of narcotic medications has been identified as a contributor to the nation’s devastating opioid epidemic. The purpose of this study is to identify risk factors for postoperative opioid dependence
Daniel D. Bohl MD, MPH +6 more
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How orthopedic surgeons can impact opioid use and dependence in shoulder arthroplasty
JSES International, 2020 Background: Considering that the United States is facing a crisis with opioid misuse and orthopedists are the third largest provider of these prescriptions, it is important to delineate risk factors associated with use and dependence.
Kiran Chatha, MD +5 more
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Epidemiological evidence on extra-medical use of prescription pain relievers: transitions from newly incident use to dependence among 12–21 year olds in the United States using meta-analysis, 2002–13 [PDF]
PeerJ, 2015 Background. When 12-to-21-year-olds start using prescription pain relievers extra-medically, some of them transition into opioid dependence within 12 months after such use.
Maria A. Parker, James C. Anthony
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Frontiers in Neural Circuits, 2022 Dysregulation of body weight maintenance and opioid dependence are often treated as independent disorders. Here, we assessed the effects of both acute and long-term administration of morphine with and without chemogenetic activation of agouti-related ...
Brenton T. Laing +6 more
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Journal of Orthopaedic Surgery and Research, 2019 Background Since the early 1990s, opioids have been used as a mainstay for pain management surrounding fracture injuries. As opioid dependence has become a major public health issue, it is important to understand what factors can leave patients ...
Vani Janaki Sabesan +4 more
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