Results 121 to 130 of about 1,069,344 (328)
Journal of Functional Foods, 2016 The opioid effect of αs1-casein fragments related to 143AYFYPEL149 and 144YFYPEL149, which had previously shown mucin-stimulatory activity in human goblet cells, was investigated.
S. Fernández-Tomé +5 more
doaj
Transport systems for opioid peptides in mammalian tissues
AAPS Journal, 2005 Transmembrane transport of endogenous as well as synthetic opioid peptides is a critical determinant of pharmacokinetics and biologic efficacy of these peptides. This transport process influences the distribution of opioid peptides across the blood-brain
V. Ganapathy, S. Miyauchi
semanticscholar +1 more source
Microscopy and spectroscopy approaches to study GPCR structure and function
British Journal of Pharmacology, EarlyView.Abstract The GPCR signalling cascade is a key pathway responsible for the signal transduction of a multitude of physical and chemical stimuli, including light, odorants, neurotransmitters and hormones. Understanding the structural and functional properties of the GPCR cascade requires direct observation of signalling processes in high spatial and ...
Tomáš Fessl +2 more
wiley +1 more source
Arrestin‐centred interactions at the membrane and their conformational determinants
British Journal of Pharmacology, EarlyView.Abstract More than 30 years after their discovery, arrestins are recognised multiprotein scaffolds that play essential roles in G protein‐coupled receptor (GPCR) regulation and signalling. Originally named for their capacity to hinder GPCR coupling to G proteins and facilitate receptor desensitisation, arrestins have emerged as key hubs for a myriad of
Owen Underwood +3 more
wiley +1 more source
Involvement of Opioid Peptides in the Analgesic Effect of Spinal Cord Stimulation in a Rat Model of Neuropathic Pain. [PDF]
Neurosci Bull, 2022 Zhai FJ +6 more
europepmc +1 more source
Cell Transplantation, 2006 We have reported that transplantation of adrenal medullary chromaffin cells that release endogenous opioid peptides into pain modulatory regions in the CNS produce significant antinociceptive effects in patients with terminal cancer pain.
Ikuko Sugaya +3 more
doaj +1 more source
Isolation and characterization of the opioid peptides from rat pituitary: beta-endorphin. [PDF]
, 1977 Menachem Rubinstein +2 more
openalex +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
Estradiol and Mu opioid-mediated reward: The role of estrogen receptors in opioid use
Addiction Neuroscience, 2023 Opioid use and opioid use disorder are characterized by sex and gender differences, and some of these differences may be mediated by differences in the hormonal milieu within and across individuals.
Sarah B. Ethridge, Mark A. Smith
doaj
Opioid Atlas: Mapping Access to Pain Medication [PDF]
arXiv, 2016 Opiates are some of the most effective pain relief medications available for patients suffering from cancer and surgery-related pain. Despite the affordability and effectiveness of these medications, access to opiates is highly geographically variable. Pain researchers have attributed geographic variation to various factors including the fear of opioid
arxiv