Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]
Mol Pharmacol, 2020 In the mid-1970s, an intense race to identify endogenous substances that activated the same receptors as opiates resulted in the identification of the first endogenous opioid peptides.
Fricker LD +3 more
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Non-Opioid Peptides Targeting Opioid Effects. [PDF]
Int J Mol Sci, 2021 Opioids are the most potent widely used analgesics, primarily, but not exclusively, in palliative care. However, they are associated with numerous side effects, such as tolerance, addiction, respiratory depression, and cardiovascular events. This, in turn, can result in their overuse in cases of addiction, the need for dose escalation in cases of ...
Kaczyńska K, Wojciechowski P.
europepmc +4 more sources
Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders. [PDF]
Nutrients, 2019 Opioid peptides released during digestion of dietary proteins such as casein, were suggested to contribute to autism development, leading to the announcement of opioid excess hypothesis of autism.
Jarmołowska B +7 more
europepmc +2 more sources
Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks [PDF]
The Journal of Poultry ScienceFreedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood.
Yuhui Zhang +4 more
doaj +2 more sources
Mycobacteria attenuate nociceptive responses by formyl peptide receptor triggered opioid peptide release from neutrophils. [PDF]
PLoS Pathogens, 2009 In inflammation, pain is regulated by a balance of pro- and analgesic mediators. Analgesic mediators include opioid peptides which are secreted by neutrophils at the site of inflammation, leading to activation of opioid receptors on peripheral sensory ...
Heike L Rittner +9 more
doaj +5 more sources
Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides. [PDF]
J Neuroinflammation, 2016 During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti-inflammatory M2 populations.
Pannell M +6 more
europepmc +2 more sources
Influence of opioid peptides on human neutrophil apoptosis and activation in vitro [PDF]
Mediators of Inflammation, 2002 Background: It has been shown that cells of the immune system release opioid peptides and possess receptors for them. The concentrations of opioid peptides in the peripheral circulation rapidly increase during inflammation and acute stress response.
Zofia Sulowska +4 more
doaj +2 more sources
Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics. [PDF]
Front Cell Neurosci, 2015 The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Sarkisyan D +10 more
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Endogenous opioid peptides in the descending pain modulatory circuit. [PDF]
Neuropharmacology, 2020 Bagley EE, Ingram SL.
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Opioid peptide-derived analgesics [PDF]
The AAPS Journal, 2005 Two recent developments of opioid peptide-based analgesics are reviewed. The first part of the review discusses the dermorphin-derived, cationic-aromatic tetrapeptide H-Dmt-D-Arg-Phe-Lys-NH(2) ([Dmt(1)]DALDA, where Dmt indicates 2',6'-dimethyltyrosine), which showed subnanomolar mu receptor binding affinity, extraordinary mu receptor selectivity, and ...
Peter W. Schiller
openalex +5 more sources