Five Decades of Research on Opioid Peptides: Current Knowledge and Unanswered Questions. [PDF]
Mol Pharmacol, 2020 In the mid-1970s, an intense race to identify endogenous substances that activated the same receptors as opiates resulted in the identification of the first endogenous opioid peptides.
Fricker LD +3 more
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Peptidomimetics and Their Applications for Opioid Peptide Drug Discovery [PDF]
Biomolecules, 2022 Despite various advantages, opioid peptides have been limited in their therapeutic uses due to the main drawbacks in metabolic stability, blood-brain barrier permeability, and bioavailability.
Yeon Sun Lee
doaj +2 more sources
Role of Milk-Derived Opioid Peptides and Proline Dipeptidyl Peptidase-4 in Autism Spectrum Disorders. [PDF]
Nutrients, 2019 Opioid peptides released during digestion of dietary proteins such as casein, were suggested to contribute to autism development, leading to the announcement of opioid excess hypothesis of autism.
Jarmołowska B +7 more
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Non-Opioid Peptides Targeting Opioid Effects. [PDF]
Int J Mol Sci, 2021 Opioids are the most potent widely used analgesics, primarily, but not exclusively, in palliative care. However, they are associated with numerous side effects, such as tolerance, addiction, respiratory depression, and cardiovascular events. This, in turn, can result in their overuse in cases of addiction, the need for dose escalation in cases of ...
Kaczyńska K, Wojciechowski P.
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Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain [PDF]
Scientific Reports, 2016 Neuropathic pain often results from peripheral nerve damage, which can involve immune response. Local leukocyte-derived opioid peptides or exogenous opioid agonists inhibit neuropathy-induced mechanical hypersensitivity in animal models.
Celik, Melih O. +3 more
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Effects of Central Administration of Opioid Peptides, Vasotocin, Mesotocin, and Corticotrophin-Releasing Factor on Water Intake in Chicks [PDF]
The Journal of Poultry ScienceFreedom from thirst is an undeniable requirement of the poultry industry. However, the regulatory mechanisms underlying water intake in chicks are not yet fully understood.
Yuhui Zhang +4 more
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eLife, 2021 Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman +4 more
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Adoptive transfer of M2 macrophages reduces neuropathic pain via opioid peptides. [PDF]
J Neuroinflammation, 2016 During the inflammation which occurs following nerve damage, macrophages are recruited to the site of injury. Phenotypic diversity is a hallmark of the macrophage lineage and includes pro-inflammatory M1 and anti-inflammatory M2 populations.
Pannell M +6 more
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Endogenous opioid peptides in the descending pain modulatory circuit. [PDF]
Neuropharmacology, 2020 Bagley EE, Ingram SL.
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Downregulation of the endogenous opioid peptides in the dorsal striatum of human alcoholics. [PDF]
Front Cell Neurosci, 2015 The endogenous opioid peptides dynorphins and enkephalins may be involved in brain-area specific synaptic adaptations relevant for different stages of an addiction cycle.
Sarkisyan D +10 more
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