Results 21 to 30 of about 45,822 (323)

Investigating the KNDy hypothesis in humans by co-administration of kisspeptin, neurokinin B and naltrexone in men [PDF]

, 2016
Context: A subpopulation of hypothalamic neurons co-localise three neuropeptides namely kisspeptin, neurokinin B (NKB) and dynorphin collectively termed KNDy neurons. Animal studies suggest they interact to affect pulsatile GnRH release (KNDy hypothesis);
Abbara, A, Bassett, P, Bloom, S, COMNINOS, A, Dhillo, WS, Jayasena, C, Mizamtsidi, M, Narayanaswamy, S, Papadopoulou, D, Prague, J, Shah, A, Veldhuis, J   +11 more
core   +1 more source

The role of respiratory failure caused by congenital central nervous system abnormalities and the effect of β-casomorphins in sudden infant death syndrome pathogenesis

Archives of Forensic Medicine and Criminology, 2015
The aim of the paper is to discuss the role of respiratory failure caused by endogenous (both structural and functional) abnormalities in the central nervous system and exogenous food-derived opioid-like peptides in the pathogenesis of sudden infant ...
Barbara Sumińska-Ziemann, Tomasz Gos, Zbigniew Jankowski   +2 more
doaj   +1 more source

Probing protein sequences as sources for encrypted antimicrobial peptides [PDF]

, 2012
Starting from the premise that a wealth of potentially biologically active peptides may lurk within proteins, we describe here a methodology to identify putative antimicrobial peptides encrypted in protein sequences.
Alan Cooper, Carlos Bloch, Eugene A. Permyakov, Francisco J. L. Aragão, Guilherme D. Brand, Jacques Nicoli, Maria L. P. Tinoco, Mariana T. Q. Magalhães, Sharon M. Kelly   +8 more
core   +7 more sources

The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio

Diabetology & Metabolic Syndrome, 2021
Background Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years.
Shatha Rouf Moustafa
doaj   +1 more source

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M., Gallagher, S. M., Unterwald, E. M., Van Bockstaele, E. J.   +3 more
core   +2 more sources

Bioactive peptides in storage proteins

Grasas y Aceites, 2000
A review on the bioactive peptides described so far in storage proteins, mainly milk proteins, has been carried out. Bioactive peptides are small amino acid sequences inactives in the native protein, but that can be liberated after hydrolysis of these ...
J. Vioque, R. Sánchez-Vioque, A. Clemente, J. Pedroche, M. M. Yust, F. Millán   +5 more
doaj   +1 more source

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

eLife, 2021
Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Manojkumar A Puthenveedu   +4 more
doaj   +1 more source

Endogenous peripheral pain regulatory systems in orofacial pain patients

Saudi Dental Journal, 2019
Introduction: Initiation of pulpal pain begins with the release of bacterial toxins and inflammatory mediators that either activate or sensitize nociceptors thereby activating the trigeminal pain pathway.
Abdulmajeed M. Al Shujaa, Claudia O. Espitia, Qun Li, Mayor Patil, Nikita B. Ruparel   +4 more
doaj   +1 more source

Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions

Frontiers in Pharmacology, 2013
Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evidence for the clinical usefulness of opioids in peripheral analgesia.
Katerina eIwaszkiewicz, Jennifer eSchneider, Susan eHua   +2 more
doaj   +1 more source

Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]

PLoS ONE, 2012
Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad, Motaz Abas, Haytham Elgharably, Ravi Tripathi, Tykie Theofilos, Sujatha Bhandary, Chittoor Sai-Sudhakar, Chandan K Sen, Sashwati Roy   +8 more
doaj   +1 more source