Results 21 to 30 of about 1,088,006 (377)
Transport and Metabolism of Opioid Peptides across BeWo Cells, An In Vitro Model of the Placental Barrier [PDF]
, 2011 Please note that this is an author-produced PDF of an article accepted for publication following peer review. The publisher version is available on its site.In keeping with the advance of biotechnology, cell culture becomes an important tool for ...
Ampasavate, Chadarat +4 more
core +3 more sources
The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk Between Ethanol and Morphine [PDF]
PharmaceuticalsBackground: There is clinical concern about the combined use of alcohol and opiates. Several lines of evidence support an interaction between alcohol and the endogenous opioid system.
Andy Tseng +3 more
doaj +2 more sources
Frontiers in Pharmacology, 2023 Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit ...
Rink-Jan Lohman +4 more
doaj +1 more source
Opioidergic pathways and kisspeptin in the regulation of female reproduction in mammals
Frontiers in Neuroscience, 2022 Endogenous opioid peptides have attracted attention as critical neuropeptides in the central mechanism regulating female reproduction ever since the discovery that arcuate dynorphin neurons that coexpress kisspeptin and neurokinin B (NKB), which are also
Yoshihisa Uenoyama +4 more
doaj +1 more source
Interactions between $β$-endorphin and kisspeptin neurons of the ewe arcuate nucleus are modulated by photoperiod [PDF]
Journal of Neuroendocrinology, In press, 2023 Opioid peptides are well-known modulators of the central control of reproduction. Among them, dynorphin coexpressed in kisspeptin (KP) neurons of the arcuate nucleus (ARC) has been thoroughly studied for its autocrine effect on KP release through $\kappa$ opioid receptors.
arxiv +1 more source
Adverse maternal environment alters Oprl1 variant expression in mouse hippocampus
The Anatomical Record, Volume 306, Issue 1, Page 162-175, January 2023., 2023 Abstract An adverse maternal environment (AME) and Western diet (WD) in early life predispose offspring toward cognitive impairment in humans and mice. Cognitive impairment associates with hippocampal dysfunction. An important regulator of hippocampal function is the hippocampal Nociceptin/Orphanin FQ (N/OFQ) system. Previous studies find links between
Xingrao Ke +5 more
wiley +1 more source
Archiv der Pharmazie, Volume 356, Issue 1, January 2023., 2023 Combining ligand‐based and structure‐based methodologies, the applied virtual screening approach identified a collection of sulfonamides targeting the human carbonic anhydrase (hCA) VA isoform. 2‐(3,4‐Dihydro‐2H‐quinolin‐1‐yl)‐N‐(4‐sulfamoylphenyl)acetamide was identified as a potent and selective lead compound as a candidate for further exploitation ...
Laura De Luca +4 more
wiley +1 more source
Biomolecules, 2020 Opioid peptides and receptors are broadly expressed throughout peripheral and central nervous systems and have been the subject of intense long-term investigations.
Ewa Gibula-Tarlowska +1 more
doaj +1 more source
Dairy, 2022 The drug-likeness and pharmacokinetic properties of 23 dairy-protein-derived opioid peptides were studied using SwissADME and ADMETlab in silico tools. All the opioid peptides had poor drug-like properties based on violations of Lipinski’s rule-of-five ...
Dawei Ji +6 more
doaj +1 more source
AAV gene therapy vectors in the TMJ
Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1561-1566, December 2022., 2022 Abstract Objectives The goal of this project was to evaluate the use of two adeno‐associated viral vector serotypes, adeno‐associated viral vectors (AAV)‐2 and AAV‐6, approved for and used for gene therapy in humans, for the delivery of therapeutic genes to the temporomandibular joint (TMJ) and the attendant sensory nerves.
Sabine M. Brouxhon +2 more
wiley +1 more source