Results 21 to 30 of about 21,048 (272)

Bioactive peptides in storage proteins

Grasas y Aceites, 2000
A review on the bioactive peptides described so far in storage proteins, mainly milk proteins, has been carried out. Bioactive peptides are small amino acid sequences inactives in the native protein, but that can be liberated after hydrolysis of these ...
J. Vioque, R. Sánchez-Vioque, A. Clemente, J. Pedroche, M. M. Yust, F. Millán   +5 more
doaj   +1 more source

The immune-opioid axis in prediabetes: predicting prediabetes with insulin resistance by plasma interleukin-10 and endomorphin-2 to kappa-opioid receptors ratio

Diabetology & Metabolic Syndrome, 2021
Background Prediabetes is characterized by a hemoglobin A1c of 5.7–6.4% and fasting blood glucose of 100–125 mg/dl. A high percentage of prediabetes subjects develop type 2 diabetes mellitus in the next years.
Shatha Rouf Moustafa
doaj   +1 more source

Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions

Frontiers in Pharmacology, 2013
Mechanisms of endogenous pain control are significant. Increasing studies have clearly produced evidence for the clinical usefulness of opioids in peripheral analgesia.
Katerina eIwaszkiewicz, Jennifer eSchneider, Susan eHua   +2 more
doaj   +1 more source

Compartment-specific opioid receptor signaling is selectively modulated by different dynorphin peptides

eLife, 2021
Many signal transduction systems have an apparent redundancy built into them, where multiple physiological agonists activate the same receptors. Whether this is true redundancy, or whether this provides an as-yet unrecognized specificity in downstream ...
Jennifer M Kunselman, Achla Gupta, Ivone Gomes, Lakshmi A Devi, Manojkumar A Puthenveedu   +4 more
doaj   +1 more source

Endogenous opioids in wound-site neutrophils of sternotomy patients. [PDF]

PLoS ONE, 2012
Postoperative pain management is a critical aspect of patient care. The inflammatory state of the post-sternotomy surgical wound sensitizes nerve endings, causing pain. Unrelieved or improperly managed pain compromises wound healing.
Hamdy Awad, Motaz Abas, Haytham Elgharably, Ravi Tripathi, Tykie Theofilos, Sujatha Bhandary, Chittoor Sai-Sudhakar, Chandan K Sen, Sashwati Roy   +8 more
doaj   +1 more source

In Silico and In Vitro Analysis of Multifunctionality of Animal Food-Derived Peptides

Foods, 2020
Currently, the associations between oxidative stress, inflammation, hypertension, and metabolic disturbances and non-communicable diseases are very well known.
Lourdes Amigo, Daniel Martínez-Maqueda, Blanca Hernández-Ledesma   +2 more
doaj   +1 more source

Opioid peptides and metabolic regulation [PDF]

Diabetologia, 1988
La liaison entre opioides et obesite pourrait passer par des anomalies de l'insulino-secretion puisque une augmentation de la sensibilite des cellules B pancreatiques a la beta-endorphine a ete demontree chez les sujets obeses. Une profonde alteration du systeme opioide est presente dans le diabete sans que l'on puisse dire encore si cela represente un
GIUGLIANO, Dario, TORELLA R, LEFEBVRE PJ, D'ONOFRIO F.   +3 more
openaire   +4 more sources

Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles

Molecules, 2020
The macrocyclic tetrapeptide cyclo[Phe-d-Pro-Phe-Trp] (CJ-15,208) and its stereoisomer cyclo[Phe-d-Pro-Phe-d-Trp] exhibit different opioid activity profiles in vivo.
Ariana C. Brice-Tutt, Sanjeewa N. Senadheera, Michelle L. Ganno, Shainnel O. Eans, Tanvir Khaliq, Thomas F. Murray, Jay P. McLaughlin, Jane V. Aldrich   +7 more
doaj   +1 more source

Peripherally Acting Opioids in Orofacial Pain

Frontiers in Neuroscience, 2021
The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid ...
Qing Liu, Qing Liu, Hongwen He, Hongwen He, Lijia Mai, Lijia Mai, Shengyan Yang, Shengyan Yang, Wenguo Fan, Fang Huang, Fang Huang   +10 more
doaj   +1 more source

Thymosin Beta 4 Is Involved in the Development of Electroacupuncture Tolerance

Frontiers in Cellular Neuroscience, 2019
Background: Electroacupuncture (EA) tolerance, a negative therapeutic effect, is a gradual decline in antinociception because of its repeated or prolonged use.
Juan Wan, Yi Ding, Sha Nan, Qiulin Zhang, Jinrui Sun, Chuanguang Suo, Mingxing Ding   +6 more
doaj   +1 more source