Results 61 to 70 of about 1,088,006 (377)

Biased Agonism of Endogenous Opioid Peptides at the μ-Opioid Receptor

Molecular Pharmacology, 2015
Biased agonism is having a major impact on modern drug discovery, and describes the ability of distinct G protein–coupled receptor (GPCR) ligands to activate different cell signaling pathways, and to result in different physiologic outcomes.
Georgina L. Thompson, J. R. Lane, Thomas Coudrat, P. Sexton, A. Christopoulos, Meritxell Canals   +5 more
semanticscholar   +1 more source

Expression and Localization of Opioid Receptors in Male Germ Cells and the Implication for Mouse Spermatogenesis. [PDF]

PLoS ONE, 2016
The presence of endogenous opioid peptides in different testicular cell types has been extensively characterized and provides evidence for the participation of the opioid system in the regulation of testicular function.
Haizea Estomba, Iraia Muñoa-Hoyos, Marta Gianzo, Itziar Urizar-Arenaza, Luis Casis, Jon Irazusta, Nerea Subirán   +6 more
doaj   +1 more source

Improved surgical outcomes following simultaneous pancreas‐kidney transplantation in the contemporary era

Clinical Transplantation, Volume 36, Issue 11, November 2022., 2022
Abstract Background Complications leading to early technical failure have been the Achilles’ heel of simultaneous pancreas‐kidney transplantation (SPKT). The study purpose was to analyze longitudinally our experience with early surgical complications following SPKT with an emphasis on changes in practice that improved outcomes in the most recent era ...
Berjesh Sharda, Colleen L. Jay, Komal Gurung, David Harriman, Venkat Gurram, Alan C. Farney, Giuseppe Orlando, Jeffrey Rogers, Matthew Garner, Robert J. Stratta   +9 more
wiley   +1 more source

Neuroimmune Interaction in the Regulation of Peripheral Opioid-mediated Analgesia in Inflammation

Frontiers in Immunology, 2016
Peripheral immune-cell-mediated analgesia in inflammation is an important endogenous mechanism of pain control. Opioid receptors localized on peripheral sensory nerve terminals are activated by endogenous opioid peptides released from immune cells to ...
Susan Hua
doaj   +1 more source

Dopamine-D1 and δ-opioid receptors co-exist in rat striatal neurons [PDF]

, 2006
Cocaine’s enhancement of dopaminergic neurotransmission in the mesolimbic pathway plays a critical role in the initial reinforcing properties of this drug. However, other neurotransmitter systems are also integral to the addiction process.
Ambrose-Lanci, L. M., Gallagher, S. M., Unterwald, E. M., Van Bockstaele, E. J.   +3 more
core   +2 more sources

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

Animal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani, Hao Li, Panpan Guo, Qiulin Zhang, Mahmoud M. Abouelfetouh, Mingxing Ding, Yi Ding   +6 more
wiley   +1 more source

Antinociceptive potency of a fluorinated cyclopeptide Dmt-c[D-Lys-Phe-p-CF3-Phe-Asp]NH2

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Opioid peptides and opiate drugs such as morphine, mediate their analgesic effects, but also undesired side effects, mostly through activation of the mu opioid receptor.
Justyna Piekielna-Ciesielska, Adriano Mollica, Stefano Pieretti, Jakub Fichna, Agata Szymaszkiewicz, Marta Zielińska, Radzisław Kordek, Anna Janecka   +7 more
doaj   +1 more source

Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis. [PDF]

PLoS ONE, 2011
It is well known that the mu-opioid receptor (MOR) plays an important role in the rewarding properties of ethanol. However, it is less clear how chronic ethanol consumption affects MOR signaling.
Li He, Jennifer L Whistler
doaj   +1 more source

Individualized Risk Assessment of Preoperative Opioid Use by Interpretable Neural Network Regression [PDF]

arXiv, 2022
Preoperative opioid use has been reported to be associated with higher preoperative opioid demand, worse postoperative outcomes, and increased postoperative healthcare utilization and expenditures. Understanding the risk of preoperative opioid use helps establish patient-centered pain management.
arxiv  

Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study

Annals of Neurology, EarlyView.
Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund, Connar Stanley James Westgate, Marie‐Louise Kulas Søborg, Agneta Henriette Snoer, Rigmor Højland Jensen, Thomas Folkman Hansen, Anja Sofie Petersen   +6 more
wiley   +1 more source