Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. [PDF]
, 2009 Although alterations in μ-opioid receptor signaling mediate excitatory effects of opiates in opioid tolerance, the molecular mechanism for the excitatory effect of acute low dose morphine, as it relates to μ-opioid receptor coupling, is presently unknown.
Bianchi, E. +3 more
core +1 more source
Journal of Pharmacological Sciences, 2005 The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
doaj
Geographic Spillover Effects of Prescription Drug Monitoring Programs (PDMPs) [PDF]
arXiv, 2021 Prescription Drug Monitoring Programs (PDMPs) seek to potentially reduce opioid misuse by restricting the sale of opioids in a state. We examine discontinuities along state borders, where one side may have a PDMP and the other side may not. We find that electronic PDMP implementation, whereby doctors and pharmacists can observe a patient's opioid ...
arxiv
Challenges for opioid receptor nomenclature: IUPHAR Review 9
British Journal of Pharmacology, 2015 Recent developments in the study of the structure and function of opioid receptors raise significant challenges for the definition of individual receptor types and the development of a nomenclature that precisely describes isoforms that may subserve ...
B. Cox +4 more
semanticscholar +1 more source
A lipidated peptide derived from the C-terminal tail of the vasopressin 2 receptor shows promise as a new $β$-arrestin inhibitor [PDF]
Pharmacological Research, 2025, 107597$\beta$-arrestins play pivotal roles in seven transmembrane receptor (7TMR) signalling and trafficking. To study their functional role in the regulation of specific receptor systems, current research relies mainly on genetic tools, as few pharmacological options are available.
arxiv +1 more source
Peranan dan pengaturan ketergantungan psikis opioid oleh tipe reseptor opioid [PDF]
, 2004 Arif Nurrochmad - Role and psychological dependenci arrangement of opioid by type of reseptor opioid Opioid receptor can be classified as p., 8, and K-opioid receptor that widely expressed in the CNS.
Arief Nurrochmad
core +1 more source
Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]
, 2013 Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika +12 more
core +3 more sources
Opioids and opioid receptors orchestrate wound repair [PDF]
Translational Research, 2017 We have previously shown that topical opioids including morphine and its congeners promote healing of full thickness ischemic wounds in rats. We examined the contribution of mu opioid receptor (MOPr)-mediated healing of full thickness ischemic wounds using MOPr and delta or kappa opioid receptor knockout (KO) mice. Wound closure in the early (day 5) as
Kalpna Gupta +9 more
openaire +3 more sources
BU10038 as a safe opioid analgesic with fewer side-effects after systemic and intrathecal administration in primates [PDF]
, 2019 © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.Background: The marked increase in mis-use of prescription opioids has greatly affected our society. One potential solution is to develop improved analgesics which have
Cami-Kobeci, Gerta +9 more
core +2 more sources
Better agonist for the opioid receptors [PDF]
Chemistry Central Journal, 2018 This commentary highlights the recent work published in journal Nature on the structural based discovery of novel analgesic compounds for opioid receptors with minimal effects. Manglik et al. selectively targeted the Gi based μOR pathway instead of the β-arrestin pathway of the opioids. The computational screening of millions of compounds showed a list
Syed Lal Badshah +3 more
openaire +3 more sources