Results 1 to 10 of about 2,450,617 (280)
IUPHAR themed review: Opioid efficacy, bias, and selectivity [PDF]
Pharmacological Research, 2023 Drugs acting at the opioid receptor family are clinically used to treat chronic and acute pain, though they represent the second line of treatment behind GABA analogs, antidepressants and SSRI’s.
Nokomis Ramos-Gonzalez +2 more
doaj +3 more sources
Frontiers in Pharmacology, 2020 Opioids are the most effective analgesics used in the clinical management of cancer pain or non-cancer pain. However, chronic opioids therapy can cause many side effects including respiratory depression, nausea, sedation, itch, constipation, analgesic ...
Li Zhang +4 more
doaj +2 more sources
Frontiers in Immunology, 2020 Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang +5 more
doaj +2 more sources
Functional modulation of human delta opioid receptor by neuropeptide FF [PDF]
BMC Neuroscience, 2005 Background Neuropeptide FF (NPFF) plays a role in physiological pain sensation and opioid analgesia. For example, NPFF potentiates opiate-induced analgesia and the delta opioid receptor antagonist naltrindole inhibits NPFF-induced antinociception.
Panula Pertti, Änkö Minna-Liisa
doaj +4 more sources
Scalable Production of Highly-Sensitive Nanosensors Based on Graphene Functionalized with a Designed G Protein-Coupled Receptor [PDF]
, 2014 We have developed a novel, all-electronic biosensor for opioids that consists of an engineered mu opioid receptor protein, with high binding affinity for opioids, chemically bonded to a graphene field-effect transistor to read out ligand binding.
Crook, Alexander +10 more
core +5 more sources
Opioid receptor activation triggering downregulation of cAMP improves effectiveness of anti-cancer drugs in treatment of glioblastoma [PDF]
Cell Cycle, 2014 Glioblastoma are the most frequent and malignant human brain tumors, having a very poor prognosis. The enhanced radio- and chemoresistance of glioblastoma and the glioblastoma stem cells might be the main reason why conventional therapies fail.
Alt, A. +7 more
core +3 more sources
Ligand and G-protein selectivity in the κ-opioid receptor
Nature, 2023 The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders^ 1 .
Jianming Han +13 more
semanticscholar +1 more source
Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain
Frontiers in Molecular Neuroscience, 2022 Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons.
Kaitlin C. Reeves +3 more
semanticscholar +1 more source
Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors
Pharmaceuticals, 2022 The delta opioid receptor is a Gi-protein-coupled receptor (GPCR) with a broad expression pattern both in the central nervous system and the body. The receptor has been investigated as a potential target for a multitude of significant diseases including ...
Yazan J. Meqbil, Richard M. van Rijn
doaj +1 more source