Results 1 to 10 of about 2,542,870 (405)
Frontiers in Pharmacology, 2020 Opioids are the most effective analgesics used in the clinical management of cancer pain or non-cancer pain. However, chronic opioids therapy can cause many side effects including respiratory depression, nausea, sedation, itch, constipation, analgesic ...
Li Zhang +4 more
doaj +2 more sources
Frontiers in Immunology, 2020 Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang +5 more
doaj +2 more sources
Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling [PDF]
Frontiers in Molecular BiosciencesHemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony +4 more
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Ligand and G-protein selectivity in the κ-opioid receptor
Nature, 2023 The κ-opioid receptor (KOR) represents a highly desirable therapeutic target for treating not only pain but also addiction and affective disorders^ 1 .
Jianming Han +13 more
semanticscholar +1 more source
Opioid Receptor-Mediated Regulation of Neurotransmission in the Brain
Frontiers in Molecular Neuroscience, 2022 Opioids mediate their effects via opioid receptors: mu, delta, and kappa. At the neuronal level, opioid receptors are generally inhibitory, presynaptically reducing neurotransmitter release and postsynaptically hyperpolarizing neurons.
Kaitlin C. Reeves +3 more
semanticscholar +1 more source
Opportunities and Challenges for In Silico Drug Discovery at Delta Opioid Receptors
Pharmaceuticals, 2022 The delta opioid receptor is a Gi-protein-coupled receptor (GPCR) with a broad expression pattern both in the central nervous system and the body. The receptor has been investigated as a potential target for a multitude of significant diseases including ...
Yazan J. Meqbil, Richard M. van Rijn
doaj +1 more source
The opioid receptor: emergence through millennia of pharmaceutical sciences
Frontiers in Pain Research, 2023 Throughout history humanity has searched for an optimal approach to the use of opioids that maximizes analgesia while minimizing side effects. This review reflects upon the conceptualization of the opioid receptor and the critical role that the ...
Carolyn A. Fairbanks +4 more
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Nanobody-enabled monitoring of kappa opioid receptor states
Nature Communications, 2020 Recent studies show that GPCRs rapidly interconvert between multiple states although our ability to interrogate, monitor and visualize them is limited by a relative lack of suitable tools.
T. Che +15 more
semanticscholar +1 more source
Pain and Therapy, 2020 Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid receptor agonists.
Jeffrey Gudin, Jeffrey Fudin
doaj +1 more source