Results 11 to 20 of about 86,994 (313)
Molecules, 2022 Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by ...
Peng Xie +8 more
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Journal of Pharmacological Sciences, 2005 The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
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Frontiers in Oncology, 2021 Opioids are administered to cancer patients in the period surrounding tumour excision, and in the management of cancer-associated pain. The effects of opioids on tumour growth and metastasis, and their consequences on disease outcome, continue to be the ...
Claudia A. Scroope +3 more
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Functional modulation of human delta opioid receptor by neuropeptide FF
BMC Neuroscience, 2005 Background Neuropeptide FF (NPFF) plays a role in physiological pain sensation and opioid analgesia. For example, NPFF potentiates opiate-induced analgesia and the delta opioid receptor antagonist naltrindole inhibits NPFF-induced antinociception.
Panula Pertti, Änkö Minna-Liisa
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Annals of Medicine, 1995 Recent experimental and clinical research has demonstrated that opioids can produce potent and receptor-specific analgesic effects outside the central nervous system. Opioid receptors are localized on peripheral terminals of sensory nerves and their endogenous ligands, opioid peptides, have been discovered in immune cells within inflamed tissue.
C, Stein, M, Schäfer, A H, Hassan
openaire +2 more sources
Modeling buprenorphine reduction of fentanyl-induced respiratory depression
JCI Insight, 2022 BACKGROUND Potent synthetic opioids, such as fentanyl, are increasingly abused, resulting in unprecedented numbers of fatalities from respiratory depression.
Erik Olofsen +8 more
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The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review
Pharmacy, 2022 The opioid epidemic is an ongoing public health crisis, and the United States health system is overwhelmed with increasing numbers of opioid-related overdoses.
Colleen G. Jordan +5 more
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Journal of Pharmacological Sciences, 2003 : The G-protein activation induced by μ-opioid receptor agonists was determined in spinal cord membranes from two types of μ-opioid receptor knockout mice: mice with a disruption of exon 1 (MOR (Exon 1)-KO) or exons 2 and 3 (MOR (Exons 2 and 3)-KO) of ...
Hirokazu Mizoguchi +8 more
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Small-molecule nociceptin receptor agonist ameliorates mast cell activation and pain in sickle mice
Haematologica, 2015 Treatment of pain with morphine and its congeners in sickle cell anemia is suboptimal, warranting the need for analgesics devoid of side effects, addiction and tolerance liability. Small-molecule nociceptin opioid receptor ligands show analgesic efficacy
Derek Vang +7 more
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