Results 11 to 20 of about 2,508,905 (426)
The opioid receptor: emergence through millennia of pharmaceutical sciences [PDF]
Frontiers in Pain Research, 2023 Throughout history humanity has searched for an optimal approach to the use of opioids that maximizes analgesia while minimizing side effects. This review reflects upon the conceptualization of the opioid receptor and the critical role that the ...
Carolyn A. Fairbanks +4 more
doaj +2 more sources
µ-Opioid receptor antagonism facilitates the anxiolytic-like effect of oxytocin in mice [PDF]
Translational PsychiatryMood and anxiety disorders are leading causes of disability worldwide and are major contributors to the global burden of diseases. Neuropeptides, such as oxytocin and opioid peptides, are important for emotion regulation.
Khalin E. Nisbett +2 more
doaj +2 more sources
Insights into the interaction between hemorphins and δ-opioid receptor from molecular modeling [PDF]
Frontiers in Molecular BiosciencesHemorphins are short atypical opioid peptide fragments embedded in the β-chain of hemoglobin. They have received considerable attention recently due to their interaction with opioid receptors.
Priya Antony +4 more
doaj +2 more sources
Prescription analgesic overuse in older adults: Can we mitigate this growing problem?
AGING MEDICINE, Volume 5, Issue 4, Page 294-296, December 2022., 2022 With older adults already on numerous prescription medications to manage their chronic conditions, the addition of pain medications could impose an even greater burden due to dependency issues. We need to understand the use of chronic pain medication, especially opioids, discuss current strategies and gaps, and offer potential solutions to mitigate ...
Sara Kakatkar +2 more
wiley +1 more source
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 131-137, January 2023., 2023 The cornerstone of treatment for symptomatic gallbladder stones is laparoscopic cholecystectomy. Pain is the commonest cause of extended hospital stay. Disturbance of liver—diaphragm surface tension is the main cause of pain. Retained CO2 is a major concern post laparoscopic cholecystectomy.
Mohamed Lotfy Ali Abuelzein +3 more
wiley +1 more source
American Journal of Hematology, Volume 98, Issue 1, Page 11-22, January 2023., 2023 Treatment process evolution. *The target TNC for BMH was ≥6 × 108/kg per patient. The Group B1 patient received lovo‐cel produced using both the original and refined manufacturing process, and the Group B2 patient received lovo‐cel produced using only the refined manufacturing process.
Julie Kanter +14 more
wiley +1 more source
Nanobody-enabled monitoring of kappa opioid receptor states
Nature Communications, 2020 Recent studies show that GPCRs rapidly interconvert between multiple states although our ability to interrogate, monitor and visualize them is limited by a relative lack of suitable tools.
T. Che +15 more
semanticscholar +1 more source
Pain and Therapy, 2020 Buprenorphine is a Schedule III opioid analgesic with unique pharmacodynamic and pharmacokinetic properties that may be preferable to those of Schedule II full μ-opioid receptor agonists.
Jeffrey Gudin, Jeffrey Fudin
doaj +1 more source
Interactions between $β$-endorphin and kisspeptin neurons of the ewe arcuate nucleus are modulated by photoperiod [PDF]
Journal of Neuroendocrinology, In press, 2023 Opioid peptides are well-known modulators of the central control of reproduction. Among them, dynorphin coexpressed in kisspeptin (KP) neurons of the arcuate nucleus (ARC) has been thoroughly studied for its autocrine effect on KP release through $\kappa$ opioid receptors.
arxiv +1 more source
Alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1: Insight into complex mu opioid actions [PDF]
, 2021 Most opioid analgesics used clinically, including morphine and fentanyl, as well as the recreational drug heroin, act primarily through the mu opioid receptor, a class A Rhodopsin-like G protein-coupled receptor (GPCR). The single-copy mu opioid receptor
Abrimian, Anna +8 more
core +2 more sources