Results 11 to 20 of about 81,908 (215)

Toll-Like Receptor 4 (TLR4)/Opioid Receptor Pathway Crosstalk and Impact on Opioid Analgesia, Immune Function, and Gastrointestinal Motility

Frontiers in Immunology, 2020
Toll-like receptor 4 (TLR4) recognizes exogenous pathogen-associated molecular patterns (PAMPs) and endogenous danger-associated molecular patterns (DAMPs) and initiates the innate immune response.
Peng Zhang, Meirong Yang, Chunhua Chen, Liu Liu, Xinchuan Wei, Si Zeng   +5 more
doaj   +1 more source

In Vitro Analyses of Spinach-Derived Opioid Peptides, Rubiscolins: Receptor Selectivity and Intracellular Activities through G Protein- and β-Arrestin-Mediated Pathways

Molecules, 2021
Activated opioid receptors transmit internal signals through two major pathways: the G-protein-mediated pathway, which exerts analgesia, and the β-arrestin-mediated pathway, which leads to unfavorable side effects. Hence, G-protein-biased opioid agonists
Yusuke Karasawa, Kanako Miyano, Hideaki Fujii, Takaaki Mizuguchi, Yui Kuroda, Miki Nonaka, Akane Komatsu, Kaori Ohshima, Masahiro Yamaguchi, Keisuke Yamaguchi, Masako Iseki, Yasuhito Uezono, Masakazu Hayashida   +12 more
doaj   +1 more source

Computational Methods for Understanding the Selectivity and Signal Transduction Mechanism of Aminomethyl Tetrahydronaphthalene to Opioid Receptors

Molecules, 2022
Opioid receptors are members of the group of G protein-couple receptors, which have been proven to be effective targets for treating severe pain. The interactions between the opioid receptors and corresponding ligands and the receptor’s activation by ...
Peng Xie, Junjie Zhang, Baiyu Chen, Xinwei Li, Wenbo Zhang, Mengdan Zhu, Wei Li, Jianqi Li, Wei Fu   +8 more
doaj   +1 more source

Opioid Receptor-Mediated and Non-Opioid Receptor-Mediated Roles of Opioids in Tumour Growth and Metastasis

Frontiers in Oncology, 2021
Opioids are administered to cancer patients in the period surrounding tumour excision, and in the management of cancer-associated pain. The effects of opioids on tumour growth and metastasis, and their consequences on disease outcome, continue to be the ...
Claudia A. Scroope, Zane Singleton, Markus W. Hollmann, Marie-Odile Parat   +3 more
doaj   +1 more source

Modification of κ-Opioid Receptor Agonist-Induced Antinociception by Diabetes in the Mouse Brain and Spinal Cord

Journal of Pharmacological Sciences, 2005
The supraspinal and spinal antinociceptive effects of several κ-opioid receptor agonists were examined in diabetic and non-diabetic mice using the tail-flick assay. The antinociception induced by intrathecal (i.t.), but not intracerebroventricular (i.c.v.
Masahiro Ohsawa, Junzo Kamei
doaj   +1 more source

Functional modulation of human delta opioid receptor by neuropeptide FF

BMC Neuroscience, 2005
Background Neuropeptide FF (NPFF) plays a role in physiological pain sensation and opioid analgesia. For example, NPFF potentiates opiate-induced analgesia and the delta opioid receptor antagonist naltrindole inhibits NPFF-induced antinociception.
Panula Pertti, Änkö Minna-Liisa
doaj   +1 more source

Lack of μ-Opioid Receptor-Mediated G-Protein Activation in the Spinal Cord of Mice Lacking Exon 1 or Exons 2 and 3 of the MOR-1 Gene

Journal of Pharmacological Sciences, 2003
: The G-protein activation induced by μ-opioid receptor agonists was determined in spinal cord membranes from two types of μ-opioid receptor knockout mice: mice with a disruption of exon 1 (MOR (Exon 1)-KO) or exons 2 and 3 (MOR (Exons 2 and 3)-KO) of ...
Hirokazu Mizoguchi, Hsiang-En Wu, Minoru Narita, Ichiro Sora, F. Scott Hall, George R. Uhl, Horace H. Loh, Hiroshi Nagase, Leon F. Tseng   +8 more
doaj   +1 more source

Modeling buprenorphine reduction of fentanyl-induced respiratory depression

JCI Insight, 2022
BACKGROUND Potent synthetic opioids, such as fentanyl, are increasingly abused, resulting in unprecedented numbers of fatalities from respiratory depression.
Erik Olofsen, Marijke Hyke Algera, Laurence Moss, Robert L. Dobbins, Geert J. Groeneveld, Monique van Velzen, Marieke Niesters, Albert Dahan, Celine M. Laffont   +8 more
doaj   +1 more source

The Potential of Methocinnamox as a Future Treatment for Opioid Use Disorder: A Narrative Review

Pharmacy, 2022
The opioid epidemic is an ongoing public health crisis, and the United States health system is overwhelmed with increasing numbers of opioid-related overdoses.
Colleen G. Jordan, Amy L. Kennalley, Alivia L. Roberts, Kaitlyn M. Nemes, Tenzing Dolma, Brian J. Piper   +5 more
doaj   +1 more source

Update on opioid receptors

British Journal of Anaesthesia, 1994
82100
ATCHESON, R, LAMBERT, DG
openaire   +4 more sources