Results 191 to 200 of about 2,513,925 (427)
British Journal of Pharmacology, 2014 GPCRs can interact with each other to form homomers or heteromers. Homomers involve interactions with the same receptor type while heteromers involve interactions between two different GPCRs.
Wakako Fujita, I. Gomes, L. Devi
semanticscholar +1 more source
Structure of the human kappa opioid receptor in complex with JDTic
Nature, 2012 Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respiratory drive, mood, and—in the case of κ-opioid receptor (κ-OR)—dysphoria and psychotomimesis. Here we report
Huixian Wu +16 more
semanticscholar +1 more source
Ibrain, EarlyView., 2023 This study compared the clinical effectiveness and treatment satisfaction of Pregabalin and Gabapentin triple therapy for neuropathic pain in a real‐world setting. The primary outcome measured the reduction in mean Self‐Administered Leeds Assessment of Neuropathic Symptoms and Signs pain score value from baseline to 12 weeks posttreatment.
Nithya Raju +7 more
wiley +1 more source
Monoclonal antibody to the message sequence Tyr-Gly-Gly-Phe of opioid peptides exhibits the specificity requirements of mammalian opioid receptors. [PDF]
, 1983 T Meo +6 more
openalex +1 more source
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)
Chemistry &Biodiversity, EarlyView.This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni +5 more
wiley +1 more source
ChemBioChem, EarlyView.The study investigates CB2 receptor (CB2R) mobility in live cells using the fluorescent probe RO7304924 and fluorescence recovery after photobleaching (FRAP). Results demonstrate the probe‘s efficiency in quantifying receptor diffusion and mobility, with CB2R showing high mobile fractions and diffusion coefficients.
Francesca Ciaramellano +9 more
wiley +1 more source
Large-scale Analysis of Opioid Poisoning Related Hospital Visits in New York State [PDF]
AMIA Annu Symp Proc. 2018;2017:545-554, 2017 Opioid related deaths are increasing dramatically in recent years, and opioid epidemic is worsening in the United States. Combating opioid epidemic becomes a high priority for both the U.S. government and local governments such as New York State. Analyzing patient level opioid related hospital visits provides a data driven approach to discover both ...
arxiv
Characterization of opioid receptors in the cat carotid body involved in chemosensory depression in vivo [PDF]
, 1986 Geoffrey C. Kirby, Daniel S. McQueen
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ChemMedChem, EarlyView.The review focuses on relationships of oxadiazole derivative structures and their antimycobacterial activity including target structures in mycobacteria, in vitro or in vivo pharmacokinetic parameters, and toxicity. Apart from direct antimycobacterial activity, some 1,2,4‐oxadiazole derivatives can potentiate the antimycobacterial effect of ethionamide
Marta Kučerová‐Chlupáčová
wiley +1 more source
Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice
Journal of Pharmacological Sciences, 2007 In the present study, we investigated whether the peripherally acting µ-opioid receptor agonist loperamide would inhibit allodynia in the non-inflamed dermatome of mice with herpetic pain.
Atsushi Sasaki +5 more
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