Results 241 to 250 of about 86,994 (313)

Sex and Strain Differences in Analgesic and Hyperlocomotor Effects of Morphine and μ-Opioid Receptor Expression in Mice. [PDF]

J Neurosci Res
Boorman DC, Rehal SK, Fazili M, Martin LJ.   +3 more
europepmc   +1 more source

Detecting cannabis use reduction through biochemical verification of urinary cannabinoids: An aggregated analysis of cannabis use disorder treatment trials examining average reductions and individual cut‐points

Addiction, EarlyView.
Abstract Background and aims Currently, there is no data‐driven cannabis reduction metric using biochemical verification, which represents a significant gap in cannabis harm reduction research, treatment and policy. Using aggregated data from 7 cannabis use disorder treatment trials, the aims of this analysis were to 1) determine if decreases in self ...
Erin A. McClure, Brian Neelon, Rachel L. Tomko, Ashley Dowd, Kevin M. Gray, Aimee L. McRae‐Clark, Nathaniel Baker   +6 more
wiley   +1 more source

Redefining Ketamine Pharmacology for Antidepressant Action: Synergistic NMDA and Opioid Receptor Interactions? [PDF]

Am J Psychiatry
Levinstein MR, Budinich RC, Bonaventura J, Schatzberg AF, Zarate CA, Michaelides M.   +5 more
europepmc   +1 more source

Varenicline for cannabis use disorder: A randomized controlled trial

Addiction, EarlyView.
Abstract Background and aims Although cannabis use is widespread and prevalence of cannabis use disorder (CUD) is increasing, limited advancements have been made in CUD medication development. The objective of this study was to test the efficacy of varenicline with medical management for reducing cannabis use in treatment‐seeking individuals with CUD ...
Aimee L. McRae‐Clark, Kevin M. Gray, Nathaniel L. Baker, Brian J. Sherman, Bryan Tolliver, Jessica Burt, Alonzo Steplight, Elizabeth Chapman, Amanda Wagner   +8 more
wiley   +1 more source

Childhood family environment and μ-opioid receptor availability in vivo in adulthood. [PDF]

Neuropsychopharmacology
Saarinen A, Tuominen L, Puttonen S, Raitakari O, Keltikangas-Järvinen L, Hietala J.   +5 more
europepmc   +1 more source

The association of methadone use with physical function and frailty among persons who inject drugs

Addiction, EarlyView.
Abstract Background and Aims Persons who inject drugs (PWID) experience a high burden of early‐onset frailty, primarily due to multifactorial causes such as infections (human immunodeficiency virus [HIV], hepatitis C virus [HCV]), substance use, and polypharmacy.
Grace L. Kulik, Hsing‐Yu Hsu, Jacqueline Rudolph, Yutong Jiang, Kristine M. Erlandson, Damani A. Piggott, Shruti Mehta, Jeremy D. Walston, Gregory Kirk, Todd T. Brown, Jing Sun   +10 more
wiley   +1 more source

Effects of social isolation on locus coeruleus opioid receptor expression and affective behavior. [PDF]

Neurobiol Stress
Tkaczynski J, Riser J, Patel M, Shellenbarger N, Park J, Manvich D, Chandler DJ.   +6 more
europepmc   +1 more source

Role of β-Arrestin 2 in the antinociceptive and side effect profile of morphine and the novel mu opioid receptor agonists, kurkinorin and kurkinol. [PDF]

Neuropsychopharmacology
van de Wetering R, Alder AF, Biggerstaff A, Sellen K, Luo D, Crowley RS, Prisinzano TE, Kivell BM.   +7 more
europepmc   +1 more source

Biased Opioid Receptor Agonists: Balancing Analgesic Efficacy and Side-Effect Profiles. [PDF]

Int J Mol Sci
Ju J, Li Z, Liu J, Peng X, Gao F.
europepmc   +1 more source

GPER Enhances Chronic Burn Pain via PKC-Mediated Mu-Opioid Receptor Phosphorylation in the Rostral Ventromedial Medulla. [PDF]

J Pain Res
Zhu X, Zhang Y, Zhang Q, Zhang Z.
europepmc   +1 more source