Results 91 to 100 of about 72,097 (314)

Pharmacological Preconditioning: Role of Opioid Peptides

open access: yesОбщая реаниматология, 2012
The review deals with the mechanisms of action of opioids and the synthetic analogue of endogenous leuenkephaline dalargin. It discusses the relation of delta-opioid receptors to the phenomenon of pharmacological preconditioning that may explain the ...
V. V. Likhvantsev   +5 more
doaj   +1 more source

Speaking of Stigma: Piloting Language Training in Addiction Counseling Coursework

open access: yesCounselor Education and Supervision, EarlyView.
ABSTRACT This pilot study examined counselor‐in‐training (CIT) attitudes and awareness regarding stigma and stigmatizing language aimed at those with substance use disorders before and after an author‐developed educational intervention. Results indicated this intervention positively impacted CIT awareness and attitudes and their ability to identify and
Amy L. Grybush   +2 more
wiley   +1 more source

Synthesis and Biological Evaluation of Bicyclic Pyrazolines with Promising Antimicrobial Activities

open access: yesChemMedChem, EarlyView.
Continuous flow technology is exploited for the generation of bicyclic pyrazolines via photo‐click reactions. These heterocyclic species contain a valuable 3D scaffold along with a polar succinimide moiety. Subsequent antimicrobial testing reveals that halogenated moieties such as chlorine atoms and trifluoromethoxy groups enhance the potency of these ...
Debora Caviglia   +4 more
wiley   +1 more source

Targeted Delivery of Lidocaine in Breast Cancer Cells via Zeolitic Imidazolate Framework‐8 Nanoparticles

open access: yesChemPhysChem, EarlyView.
Drug repositioning of lidocaine from local anesthetic to theranostic agent for breast cancer cells is enhanced by its encapsulation inside ZIF‐8 metal–organic framework. The aim of this article is to use zeolitic imidazolate framework‐8 (ZIF‐8) metal–organic frameworks (MOFs) as drug delivery system for lidocaine, a local anesthetic with recently ...
Nicola di Nicola   +7 more
wiley   +1 more source

Impact of First‐of‐Its‐Kind Patient‐Facing Pharmacogenetics Tool on Dosing Decisions and Treatment Outcomes

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Germline pharmacogenetics (PGx) is increasingly used to tailor medication selection/dosing. However, existing systems primarily communicate PGx results to providers, limiting direct patient engagement. To address this, we developed YourPGx Oncology, an innovative patient‐facing portal that delivers multi‐gene PGx results (CYP2D6, UGT1A1, DPYD) through ...
Youngwoo Cho   +15 more
wiley   +1 more source

In-vivo studies on kappa opioid receptors [PDF]

open access: green, 1986
Alan Cowan, Debra E. Gmerek
openalex   +1 more source

Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo‐Pyridyl Synthetic Cannabinoid Receptor Agonist CH‐FUBBMPDORA

open access: yesDrug Testing and Analysis, EarlyView.
Another Chinese generic ban‐evading SCRA, CH‐FUBBMPDORA, has emerged. This study reports its first identification in Europe, its analytical characterization (NMR, Raman, FTIR, GC–MS, and HRMS), its cannabinoid activation potential in a βarr2 recruitment assay, and its metabolization profile.
Marie H. Deventer   +13 more
wiley   +1 more source

Anatomical relationship between opioid peptides and receptors in rhesus monkey brain [PDF]

open access: green, 1984
Michael E. Lewis   +3 more
openalex   +1 more source

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