Results 121 to 130 of about 2,447,948 (384)

Biased Opioid Ligands

Molecules, 2020
Achieving effective pain management is one of the major challenges associated with modern day medicine. Opioids, such as morphine, have been the reference treatment for moderate to severe acute pain not excluding chronic pain modalities.
Abdelfattah Faouzi, Balázs R Varga, S. Majumdar   +2 more
semanticscholar   +1 more source

Efficacy of a Tumor Necrosis Factor Inhibitor in Chronic Low‐Back Pain With Modic Type 1 Changes: A Randomized Controlled Trial

Arthritis &Rheumatology, EarlyView.
Efficacy of a Tumor necrosis inhibitor in chronic low‐back pain with Modic type 1 changes: The BackToBasic study, A randomized controlled trial. Objective The efficacy of tumor necrosis factor inhibitors for treating chronic low‐back pain with Modic changes is uncertain.
Elisabeth Gjefsen, Lars C. Bråten, Erica Ponzi, Magnhild H. Dagestad, Gunn H. Marchand, Thomas Kadar, Gunnstein Bakland, Anne J. Haugen, Fredrik Granviken, Tonje W. Flørenes, Nils Vetti, Lars Grøvle, Aksel T. Nilsen, Astrid Lunestad, Thor E. Holmgard, Morten Valberg, Nils Bolstad, Ansgar Espeland, Jens I. Brox, Guro L. Goll, Kjersti Storheim, John‐Anker Zwart   +21 more
wiley   +1 more source

IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics

Pharmacological Research, 2023
Though efficacious in managing chronic, severe pain, opioid analgesics are accompanied by significant adverse effects including constipation, tolerance, dependence, and respiratory depression.
Kyle J. Rehrauer, Christopher W. Cunningham   +1 more
doaj  

Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile

Frontiers in Psychiatry, 2018
A series of 14β-acyl substituted 17-cyclopropylmethyl-7,8-dihydronoroxymorphinone compounds has been synthesized and evaluated for affinity and efficacy for mu (MOP), kappa (KOP), and delta (DOP) opioid receptors and nociceptin/orphanin FQ peptide (NOP ...
Vinod Kumar, Willma E. Polgar, Gerta Cami-Kobeci, Mark P. Thomas, Taline V. Khroyan, Lawrence Toll, Stephen M. Husbands   +6 more
doaj   +1 more source

Changes in Descending Pain Modulation During Anti–Tumor Necrosis Factor Therapy: A Prospective Study in Rheumatoid Arthritis and Spondyloarthritis

Arthritis &Rheumatology, EarlyView.
Objective In rheumatoid arthritis (RA) and spondyloarthritis (SpA), managing persistent pain remains challenging. Little is known regarding impaired pain pathways in these patients and the impact of biologic disease‐modifying antirheumatic drugs (bDMARDs).
Anne‐Priscille Trouvin, Arielle Simunek, Joël Coste, Terkia Medkour, Alice Combier, Lucile Poiroux, François Vidal, Sandrine Carvès, Didier Bouhassira, Serge Perrot   +9 more
wiley   +1 more source

Interactions of the opioid and cannabinoid systems in reward: Insights from knockout studies

Frontiers in Pharmacology, 2015
The opioid system consists of three receptors, mu, delta, and kappa, which are activated by endogenous opioid peptides (enkephalins, endorphins and dynorphins). The endogenous cannabinoid system comprises lipid neuromodulators (endocannabinoids), enzymes
Katia eBefort
doaj   +1 more source

Discovering heterogeneous subpopulations for fine-grained analysis of opioid use and opioid use disorders [PDF]

arXiv, 2018
The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic.
arxiv  

Acute cardiovascular effects associated with the use of prescription medications: A Danish nationwide screening study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim This study aims to conduct a hypothesis‐generating screening for acute cardiovascular effects of prescription medications. Methods This Danish nationwide screening study was conducted among incident cases of cardiovascular diseases, including myocardial infarction (MI), ischemic stroke (IS), heart failure (HF), venous thromboembolism (VTE),
Saad Hanif Abbasi, Lars Christian Lund, Jesper Hallas, Martin Thomsen Ernst, Anton Pottegård   +4 more
wiley   +1 more source

Variation in the infant health effects of the women, infants, and children program by predicted risk using novel machine learning methods

Health Economics, Volume 32, Issue 1, Page 194-217, January 2023., 2023
Abstract The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) has an extensive literature documenting positive effects on infant health outcomes, specifically preterm birth, low birthweight, small size for gestational age, and infant mortality.
Evan D. Peet, Dana Schultz, Susan Lovejoy, Fuchiang (Rich) Tsui   +3 more
wiley   +1 more source

Boesenbergia rotunda Ethanolic Extract Inhibits Compound Action Potentials via Opioid Receptors

Life Sciences, Medicine and Biomedicine, 2018
Boesenbergia rotunda, traditionally used to relieve stomach, abdomen, joint, muscle, and rheumatic pain was also reported for its antinociceptive effect on a mouse model. However, the possible pain relief effect of Boesenbergia rotunda ethanolic extract (
Banulata Gopalsamy, Jasmine Siew Min Chia, Farihah Hanani Ghazali, Ammar Izzati Amir Ramadan, Siong Jun Wong, Ahmad Akira Omar Farouk, Mohd Roslan Sulaiman, Mohd Khairi Hussain, Enoch Kumar Perimal   +8 more
doaj   +1 more source