Distinct Alterations of Inflammatory Biomarkers in Cluster Headache: A Case Control Study
Objective Investigate the immune system's role in cluster headache by analyzing cytokines in people with cluster headache and headache‐free controls, and explore if certain cytokines could predict a specific phenotype. Methods We measured 45 cytokines in adult participants from the Danish Cluster Headache Biobank in a prospective case–control setup ...
Nunu Laura Timotheussen Lund+6 more
wiley +1 more source
Hospitalist perspectives on buprenorphine treatment for inpatients with opioid use disorder
Background: Patients with opioid use disorder (OUD) have high hospital admission rates. Hospitalists, clinicians that work in inpatient medical settings, may have a unique opportunity to intervene on behalf of these patients, yet their experience with ...
Megan K Reed+5 more
doaj
Multi-objective Molecular Optimization for Opioid Use Disorder Treatment Using Generative Network Complex [PDF]
Opioid Use Disorder (OUD) has emerged as a significant global public health issue, with complex multifaceted conditions. Due to the lack of effective treatment options for various conditions, there is a pressing need for the discovery of new medications. In this study, we propose a deep generative model that combines a stochastic differential equation (
arxiv
Background Clinical guidelines in the United States (U.S.) recommend a patient-centered approach to healthcare for pregnant people with substance use disorders (SUD); however, pregnant people with SUD often describe experiencing stigmatization and shame ...
Carol Y. Franco-Rowe+5 more
doaj +1 more source
Advances in the treatment of opioid use disorders [PDF]
The development of medications for treating persons with opioid use disorders has expanded the number of evidence-based treatment options, particularly for persons with the most severe disorders. It has also improved outcomes compared to psychosocial treatment alone and expanded treatment availability by increasing the number of physicians involved in ...
openaire +3 more sources
Identifying the Optimal Therapeutic Strategy in the Treatment of Substance Use Disorders: Can Pharmacological Therapies Prevent Relapse in Opioid- and Alcohol-Addicted Patients? [PDF]
The addiction to opioids and alcohol is one of the most significant public health concerns worldwide. One of the current approaches to the treatment of substance use disorders is the use of pharmacological therapy.
Peterkin, Melissa
core
Objective The United States is in the fourth wave of the opioid epidemic marked by the increase in fentanyl and co‐occurring stimulant use related overdose deaths.
Angela Di Paola+2 more
doaj +1 more source
Discovering heterogeneous subpopulations for fine-grained analysis of opioid use and opioid use disorders [PDF]
The opioid epidemic in the United States claims over 40,000 lives per year, and it is estimated that well over two million Americans have an opioid use disorder. Over-prescription and misuse of prescription opioids play an important role in the epidemic.
arxiv
Individualized Risk Assessment of Preoperative Opioid Use by Interpretable Neural Network Regression [PDF]
Preoperative opioid use has been reported to be associated with higher preoperative opioid demand, worse postoperative outcomes, and increased postoperative healthcare utilization and expenditures. Understanding the risk of preoperative opioid use helps establish patient-centered pain management.
arxiv
Opioid Addiction 2016 Facts & Figures [PDF]
National Opioid Overdose Epidemic* Drug overdose is the leading cause of accidental death in the US, with 55,403 lethal drug overdoses in 2015. Opioid addiction is driving this epidemic, with 20,101 overdose deaths related to prescription pain relievers,
core