Results 31 to 40 of about 45,788 (261)

Psychosis following Tramadol Withdrawal [PDF]

Addiction and Health, 2010
Background: Tramadol is a centrally acting opioid analgesic used to treat moderate to sever pain. It has more advantage and less opioid adverse effects than conventional opioid analgesia.
Ghodratolah Rajabizadeh, Ali Kheradmand, Mansoureh Nasirian   +2 more
doaj  

Effectiveness and Safety of Haloperidol Add-on Methadone in Acute Opium Withdrawal Symptoms of Opioid-dependent Patients: A Double-blind Randomized Placebo-controlled Clinical Trial [PDF]

Addiction and Health, 2021
Background: The aim of this double-blind clinical trial was to evaluate the efficacy and safety of haloperidol on acute opioid withdrawal symptoms. Methods: In this randomized double-blind clinical trial, fifty-two eligible patients were assigned to two ...
Fattaneh Ghaderi-Bafti, Mehran Zarghami, Abdolkarim Ahmadi, Mahmood Moosazadeh, Pezhman Hadinezhad, Narjes Hendouei   +5 more
doaj   +1 more source

Naloxone precipitated withdrawal increases dopamine release in the dorsal striatum of opioid dependent men

Translational Psychiatry, 2021
Dopamine (DA) neurotransmission is critical in the neurobiology of reward and aversion, but its contribution to the aversive state of opioid withdrawal remains unknown in humans.
Ehsan Shokri-Kojori, Gene-Jack Wang, Nora D. Volkow   +2 more
doaj   +1 more source

Opioid withdrawal presenting as delirium and role of buprenorphine: A case series

Indian Journal of Psychological Medicine, 2017
Opioid withdrawal is very rarely characterized by delirium unlike alcohol or benzodiazepine withdrawal. PubMed search through October 2016 reveals only two case series on delirium as feature of withdrawal in opioid dependence syndrome.
Sourav Das, Divyashree Sah, Shiladitya Nandi, Payel Das   +3 more
doaj   +1 more source

How Do We Taper and Discontinue Opioids in Cancer Patients? Considerations from the Activities of a Palliative Care Team at a University Hospital

Palliative Medicine Reports, 2021
Background: The more the cancer treatments progress, the more the needs increase to taper and discontinue opioids in cancer patients. Furthermore, opioid dependence of cancer survivors has become a bigger problem.
Ayumi Kihara, Kazuki Shimada, Satoru Tsuneto   +2 more
doaj   +1 more source

Hederagenin Attenuates Morphine Addiction via GABAA1‐Mediated Modulation of Ca2+–CaMK–CREB Signaling in Ventral Tegmental Dopaminergic Neurons

Advanced Science, EarlyView.
Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang, Ziting Zhou, Nannan Xue, Jiasi Deng, Yuanyuan Zhou, Xinying Lv, Yuxuan Wang, Yi Zhang, Haotian Pan, Geyan Xu, Yinkun Tao, Mengran Li, Xin Cui, Hongyue Ma, Qian Wang, Zhigang Lu   +15 more
wiley   +1 more source

STING/Type I Interferon Pathway Activation Confers Multimodal Therapeutic Benefits in Osteomyelitis

Advanced Science, EarlyView.
STING/type I interferon signaling counteracts osteomyelitis through coordinated control of pain, bone destruction, and abscess formation. It inhibits pathogen‐induced nociceptor activation, restrains osteoclast‐mediated bone resorption, and suppresses IL‐1β‐driven neutrophil recruitment.
Yang Chen, Jianhua Lv, Yuanqing Cai, Xuhui Yuan, Hongxin Hu, Jiayu Li, Yiming Lin, Hongyan Li, Lan Lin, Huangfeng Lin, Chaofan Zhang, Qijin Wang, Ying Huang, Zida Huang, Wenbo Li, Susheng Niu, Jianhua Lin, Bin Yang, Xinyu Fang, Wenming Zhang   +19 more
wiley   +1 more source

Opioid antagonists under heavy sedation or anaesthesia for opioid withdrawal [PDF]

Cochrane Database of Systematic Reviews, 2002
Withdrawal (detoxification) is necessary prior to drug-free treatment. It may also represent the end point of long-term opioid replacement treatment such as methadone maintenance. The availability of managed withdrawal is essential to an effective treatment system.To assess the effectiveness of interventions involving the administration of opioid ...
Gowing, L., Ali, R., White, J.
openaire   +7 more sources

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

κ-Opioid receptor antagonism reverses heroin withdrawal-induced hyperalgesia in male and female rats

Neurobiology of Stress, 2021
Although opioids are potent analgesics, a consequence of chronic opioid use is hyperalgesia during withdrawal, which may contribute to opioid misuse. Dynorphin, the endogenous ligand of κ-opioid receptors (KORs), is upregulated in opioid-dependent rats ...
Renata C.N. Marchette, Adriana Gregory-Flores, Brendan J. Tunstall, Erika R. Carlson, Shelley N. Jackson, Agnieszka Sulima, Kenner C. Rice, George F. Koob, Leandro F. Vendruscolo   +8 more
doaj   +1 more source