Results 41 to 50 of about 45,788 (261)

Opioid withdrawal manifesting with delirium.

Ind Psychiatry J
Pandey K, Chauhan VS, Nath S, Singh R.
europepmc   +4 more sources

EphB1 Receptor Blockade Augments Morphine Antinociception via Inhibiting GRK2‐Mediated µ‐Opioid Receptor Internalization

Advanced Science, EarlyView.
Administration of opioids activates ephrinB2‐EphB1 receptor signaling. Activated EphB1 receptors induce GRK2‐mediated phosphorylation of MOR at Ser375, which initiates the internalization of MOR and reduces opioid antinociception at the behavioral level. ABSTRACT Opioids are the primary treatment for severe pain in clinical practice.
Bo Peng, Xiaqing Lin, Hongyu Yao, Cheng Li, Huabao Liao, Yuexin Liu, Boxu Cao, Xue‑Jun Song   +7 more
wiley   +1 more source

The EXPLAIN Study: Exploring Arthrogryposis Multiplex Congenita in Adults in Norway — A Description of Demographic, Medical, and Neurological Findings

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Arthrogryposis Multiplex Congenita (AMC) encompasses several hundred conditions with diverse genetic, pathophysiological, and clinical origins. The overarching EXPLAIN study explores underlying causes and implications of AMC and represents the largest clinical cohort of adults with AMC reported to date.
My Vuong Hermansen, Kristin Ørstavik, Unni Steen, Mathias Toft, Cathrine Brunborg, Lena Lande Wekre   +5 more
wiley   +1 more source

Pannexin-1 channel inhibition alleviates opioid withdrawal in rodents by modulating locus coeruleus to spinal cord circuitry

Nature Communications
Opioid withdrawal is a liability of chronic opioid use and misuse, impacting people who use prescription or illicit opioids. Hyperactive autonomic output underlies many of the aversive withdrawal symptoms that make it difficult to discontinue chronic ...
Charlie H. T. Kwok, Erika K. Harding, Nicole E. Burma, Tamara Markovic, Nicolas Massaly, Nynke J. van den Hoogen, Sierra Stokes-Heck, Eder Gambeta, Kristina Komarek, Hye Jean Yoon, Kathleen E. Navis, Brendan B. McAllister, Julia Canet-Pons, Churmy Fan, Rebecca Dalgarno, Evgueni Gorobets, James W. Papatzimas, Zizhen Zhang, Yuta Kohro, Connor L. Anderson, Roger J. Thompson, Darren J. Derksen, Jose A. Morón, Gerald W. Zamponi, Tuan Trang   +24 more
doaj   +1 more source

Orally Administered N-Oleoyl Alanine Blocks Acute Opioid Withdrawal Induced-Conditioned Place Preference and Attenuates Somatic Withdrawal following Chronic Opioid Exposure in Rats

Psychoactives
(1) Background: Intraperitoneal injections of the endogenous N-acyl amino acid N-Oleoyl alanine (OlAla) effectively reduces both the affective and somatic responses produced by opioid withdrawal in preclinical models. To increase the translational appeal
Samantha M. Ayoub, Erin M. Rock, Cheryl L. Limebeer, Marieka V. DeVuono, Linda A. Parker   +4 more
doaj   +1 more source

Opioid withdrawal due to Twiddler syndrome [PDF]

Neurology, 2011
A 42-year-old man presented to the emergency department with diffuse pain, hot/cold flashes, nausea, jitteriness, and extreme tiredness. He had been treated with intrathecal morphine infusion (4 mg morphine sulfate/day) for failed back surgery syndrome. He had …
Moens, Maarten, De Smedt, Ann, Brouns, Raf   +2 more
openaire   +3 more sources

Do drugs approved via expedited approval pathways have therapeutic advantages? A systematic review and meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Regulators use expedited approval pathways to speed market approval and patient access to promising new drugs. However, there is uncertainty about whether these pathways are successful in approving drugs with significant therapeutic advantages. This systematic review aims to examine the safety, effectiveness and cost‐effectiveness of drugs approved via
Ashleigh Hooimeyer, Eliza J. McEwin, Zhicheng Wang, Joel Lexchin, Barbara Mintzes   +4 more
wiley   +1 more source

Paediatric clonidine medication errors: Findings from a multicentre French study

British Journal of Clinical Pharmacology, EarlyView.
Aims This study aimed to describe the characteristics of medication errors involving clonidine in paediatric patients and reported to French Network of Pharmacovigilance and Poison Control Centres. Methods This retrospective observational study analysed clonidine‐related medication errors reported between 1985 and June 2024 in patients under 12 years ...
Eve‐Marie Thillard, Anthony Facile, Marion Lepelley, Morgane Cellier, Laurent Chouchana, Sophie Gautier, Ramy Azzouz, Thierry Vial, Annie‐Pierre Jonville‐Bera   +8 more
wiley   +1 more source

Buprenorphine therapy in the setting of induced opioid withdrawal from oral naltrexone: a case report

Harm Reduction Journal, 2020
Background Patients with opioid use disorder (OUD) frequently present to the emergency department for acute treatment of overdose and withdrawal. Case presentation A 29-year-old male presented to the emergency room after intravenous heroin use followed ...
Laura M. Szczesniak, Vincent J. Calleo, Ross W. Sullivan   +2 more
doaj   +1 more source

Operational definition of precipitated opioid withdrawal

Frontiers in Psychiatry, 2023
BackgroundOpioid withdrawal can be expressed as both a spontaneous and precipitated syndrome. Although spontaneous withdrawal is well-characterized, there is no operational definition of precipitated opioid withdrawal.MethodsPeople (N = 106) with opioid use disorder maintained on morphine received 0.4 mg intramuscular naloxone and completed self-report
Kelly E. Dunn, H. Elizabeth Bird, Cecilia L. Bergeria, Orrin D. Ware, Orrin D. Ware, Eric C. Strain, Andrew S. Huhn   +6 more
openaire   +3 more sources