Results 111 to 120 of about 4,457,338 (303)

Phosphatidic Acid‐TRIM59‐Olig2 Signaling Couples Metabolic Dysfunction to Myelination Failure in PWMI

Advanced Science, EarlyView.
PA accumulates after hypoxic‐ischemic injury and stabilizes the E3 ligase TRIM59 in OPCs. Stabilized TRIM59 enhances ubiquitination and degradation of Olig2, blocking differentiation and causing hypomyelination in PWMI. Modulating PA synthesis restores Olig2 levels, improves myelination, and ameliorates behavioral deficits, defining a metabolically ...
Xinyu Li, Yanan Liu, Meng Zhang, Yiwei Liu, Meiting Liu, Kaishen Zhu, Zhian Liu, Chao Ren, Ruiqin Yao   +8 more
wiley   +1 more source

Metarhizium anisopliae Mitigates the Phytotoxicity of Lead and Nanoplastics on Rice by Modifying Physiological, Transcriptomic, Metabolomic Activities, and Soil Microbiome

Advanced Science, EarlyView.
Metarhizium anisopliae alleviates the phytotoxic effects of polyethylene nanoplastics (NP) and lead (Pb) in rice by decreasing Pb uptake, restoring antioxidant and hormonal equilibrium, and promoting growth. Additionally, the fungus modifies the rhizosphere microbiota, enhancing both contaminant tolerance and plant growth, thereby effectively ...
Jing Peng, Qi Yan, Muhammad Umair Hassan, Muhammad Imran, Fasih Ullah Haider, Jianfeng Liang, Xingmin Wang, Shaukat Ali   +7 more
wiley   +1 more source

1H NMR Fingerprinting of Medicinal Herbs Contain Chemical Drug Material Allopurinol

Majalah Obat Tradisional, 2018
A study to differentiate the pure medicinal herbs from the mix medicinal herbs with chemical drug material has been done. For this purpose, we conducted fingerprinting of commercial medicinal herbs and chemical drug material allopurinol using 1H-NMR ...
Adita Yuniati Puspitasari, Hanro Dwi Pranowo, Respati Tri Swasono, Tri Rini Nuringtyas   +3 more
doaj   +1 more source

Anti-malarial drug artesunate restores metabolic changes in experimental allergic asthma [PDF]

, 2016
The anti-malarial drug artesunate possesses anti-inflammatory and anti-oxidative actions in experimental asthma, comparable to corticosteroid. We hypothesized that artesunate may modulate disease-relevant metabolic alterations in allergic asthma.
Cheng, Chang, Ho, Wanxing Eugene, Huang, Shao-Min, Ong, Choon Nam, Peh, Hong Yong, Tannenbaum, Steven R, Wong, W. S. Fred, Xu, Fengguo, Xu, Yong-Jiang   +8 more
core   +1 more source

A “Hot Spring” Mimetic Aerogel Loaded with Multiple Amino Acids Modulates the Chronic Inflammatory Microenvironment Through Metabolic Reprogramming

Advanced Science, EarlyView.
The SrCuSi4O₁₀ bioceramic particles mimic the effects of hot spring therapy by increasing the local wound temperature, which enhances the absorption of amino acids and stimulates cell metabolism. The amino acid uptake supports cellular glutathione redox reactions, helping to mitigate oxidative stress.
Bo Li, Dandan Jin, Fei Li, Jianliang Shen, Jiang Chang, Chen Yang, Shixuan Chen, Yi Zhang   +7 more
wiley   +1 more source

Gut microbiota related to Giardia duodenalis, Entamoeba spp. and Blastocystis hominis infections in humans from Côte d'Ivoire. [PDF]

, 2016
INTRODUCTION: Literature data provide little information about protozoa infections and gut microbiota compositional shifts in humans. This preliminary study aimed to describe the fecal bacterial community composition of people from Côte d'Ivoire ...
Berrilli, F, D'Alfonso, R., Di Cave, D, Di Cristanziano, V, Iebba, Valerio, Monsia, A, Pantanella, Fabrizio, Santangelo, Floriana, Schippa, Serena, Totino, Valentina   +9 more
core   +2 more sources

Polydopamine‐Encapsulated Probiotics Restore Gut Homeostasis and Reinstate Macrophage Efferocytosis in Systemic Lupus Erythematosus

Advanced Science, EarlyView.
Polydopamine‐encapsulated probiotics restore gut homeostasis and reinstate macrophage efferocytosis, thereby reestablishing immune tolerance and mitigating systemic autoimmunity, highlighting a bioengineered microbiota‐based therapeutic strategy for SLE.
Ruimiao Wu, Mei Liu, Changxing Gao, Cheng Zhao, Feijie Zhao, Shuqing Dong, Bo Zhang, Qianmei Liu, Wenqian Zhang, Ming Zhao, Qianjin Lu   +10 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Resolving Oxidative and Corrosive Calendar‐Aging via Electrolyte Engineering for Stable Lithium Metal Batteries

Advanced Energy Materials, EarlyView.
A weakly solvating ether solvent, 1,2‐dimethoxypropane (DMP), is proposed for use in localized high‐concentration electrolytes (LHCEs) for lithium metal batteries (LMBs). These DMP‐based LHCEs simultaneously suppress lithium metal corrosion and cathode degradation—two interrelated processes that accelerate calendar aging of LMBs.
Jisub Kim, Ihnkyung Jung, Kyunam Lee, Insu Hwang, Minkwan Kim, Eunseok Park, Dongmin Park, Hayoung Park, Yonggoon Jeon, Gaeun Park, Hyo Chul Ahn, Jihoon Oh, Jungwon Park, Ali Coskun, Jang Wook Choi   +14 more
wiley   +1 more source

Stabilizing Magnesium Anodes in Rechargeable Magnesium Batteries via Fluorinated Cyclic Ether Electrolyte Additive

Advanced Energy Materials, EarlyView.
A fluorinated cyclic ether, FDOL, is shown to stabilize Mg metal anodes by tuning Mg2+ solvation of the G2 electrolyte. The G2‐FDOL electrolyte suppresses passivation and thick, diffusion‐blocking Mg deposits, enabling more uniform Mg plating/stripping and sustained interfacial reactions.
Hafiz Ahmad Ishfaq, Andrijana Marojević, Carolina Cruz Cardona, Gregor Kapun, Elena Tchernychova, Olivera Lužanin, Jan Bitenc, Miran Gaberšček, Robert Dominko, Sara Drvarič Talian   +9 more
wiley   +1 more source