Results 41 to 50 of about 1,103,257 (330)
Molecular Therapy: Methods & Clinical DevelopmentAdeno-associated viral (AAV) vectors are being used increasingly in developing treatments for age-related ocular diseases, including those impacting retinal ganglion cells (RGCs), the output neurons of the eye.
Delaney CM. Henderson +1 more
doaj +1 more source
Low-Field Magnetic Resonance Imaging Findings in 18 Dogs With Presumed Optic Neuritis
Frontiers in Veterinary Science, 2021 Canine optic neuritis has been attributed to a focal or disseminated form of granulomatous meningoencephalitis (GME) amongst other etiologies. Magnetic resonance imaging (MRI) has been proven to help differentiate the structures within the optic nerve ...
Laura Muñiz Moris +2 more
doaj +1 more source
Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease [PDF]
, 2010 It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease.
Angus M. Brown +10 more
core +2 more sources
Finite Element Analysis Predicts Large Optic Nerve Head Strains During Horizontal Eye Movements.
Investigative Ophthalmology and Visual Science, 2016 PURPOSE We combined finite element (FE) analysis and dynamic magnetic resonance imaging (MRI) to estimate optic nerve head (ONH) strains during horizontal eye movements, and identified factors influencing such strains.
Xiaofei Wang +8 more
semanticscholar +1 more source
Optic nerve astrocyte reactivity protects function in experimental glaucoma and other nerve injuries
Journal of Experimental Medicine, 2017 Reactive remodeling of optic nerve head astrocytes is consistently observed in glaucoma and other optic nerve injuries. However, it is unknown whether this reactivity is beneficial or harmful for visual function.
Daniel Sun, S. Moore, T. Jakobs
semanticscholar +1 more source
Shared and Differential Retinal Responses against Optic Nerve Injury and Ocular Hypertension
Frontiers in Neuroscience, 2017 Glaucoma, one of the leading causes of blindness worldwide, affects primarily retinal ganglion cells (RGCs) and their axons. The pathophysiology of glaucoma is not fully understood, but it is currently believed that damage to RGC axons at the optic nerve
M. Vidal-Sanz +12 more
semanticscholar +1 more source
Current Issues in Molecular BiologyGlaucoma is a leading cause of irreversible blindness, normally associated with dysfunction and degeneration of the trabecular meshwork (TM) as the primary cause.
Rong Du +5 more
doaj +1 more source
Astrocytes in the Optic Nerve Head of Glaucomatous Mice Display a Characteristic Reactive Phenotype
Investigative Ophthalmology and Visual Science, 2017 Purpose Optic nerve head astrocytes, a subtype of white-matter astrocytes, become reactive early in the course of glaucoma. It was shown recently that in the DBA/2J mouse model of inherited glaucoma optic nerve astrocytes extend new longitudinal ...
Rui Wang, P. Seifert, T. Jakobs
semanticscholar +1 more source
Investigative Ophthalmology and Visual Science, 2016 PURPOSE Visual impairment and intracranial pressure (VIIP) syndrome is a health concern for long-duration spaceflight, and a proposed risk factor is elevation of intracranial pressure (ICP).
A. Feola +6 more
semanticscholar +1 more source
Lipid profiling dataset of the Wnt3a-induced optic nerve regeneration
Data in Brief, 2019 We present lipid profiling data from mouse retina and optic nerve after optic nerve crush and during Wnt3a-induced axonal regeneration at 7 and 15 days post-crush. This data is available at the Metabolomics Workbench, http://www.metabolomicsworkbench.org
Anna Trzeciecka +3 more
doaj +1 more source