Results 81 to 90 of about 183,318 (235)

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

open access: yesAging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox   +13 more
wiley   +1 more source

Unilateral asymptomatic optic disc edema: do not forget sinusitis [PDF]

open access: yes, 2022
Background: Optic disc edema is a pathological condition with various causes. Cases of optic disc swelling should be dealt with a multidisciplinary approach to rule out those causes.
Jacob, Sajeev Cherian   +2 more
core   +2 more sources

Semaglutide and non‐arteritic anterior ischaemic optic neuropathy: Review and interpretation of reported association

open access: yesActa Ophthalmologica, EarlyView.
Abstract This review covers a seminal study of the relation between exposure to the glucagon‐like peptide 1 (GLP‐1) agonist semaglutide and incident non‐arteritic anterior ischaemic optic neuropathy (NAION) in a neuro‐ophthalmology clinic setting, subsequent studies in unselected populations, a meta‐analysis of clinical trials and pathophysiology ...
Abdullah Amini   +2 more
wiley   +1 more source

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye [PDF]

open access: yes, 2004
PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS.
Al Hosaini, H   +5 more
core   +1 more source

Paediatric Idiopathic Intracranial Hypertension (IIH)-A Review.

open access: yes, 2021
Paediatric idiopathic intracranial hypertension (IIH), is a rare but important differential diagnosis in children presenting with papilloedema. It is characterised by raised intracranial pressure in the absence of an identifiable secondary structural or ...
Malem, Andrew   +2 more
core   +1 more source

Correlation of Structure With Function: Future Utilities for Optical Coherence Tomography Angiography in Neuro‐Ophthalmology

open access: yesClinical &Experimental Ophthalmology, EarlyView.
ABSTRACT Optical coherence tomography angiography is a burgeoning imaging modality in Ophthalmology. In this review, we outline the breadth of potential utility for optical coherence tomography angiography for diagnosis and prognostication in neuro‐ophthalmology.
Marzieh Tahmasebi Sarvestani   +2 more
wiley   +1 more source

Comparison of Spectral-Domain OCT versus Swept-Source OCT for the Detection of Deep Optic Disc Drusen

open access: yesDiagnostics, 2022
Deep optic disc drusen (ODD) are located below Bruch’s membrane opening (BMO) and may go undetected due to the challenges in imaging them. The purpose of this study is a head-to-head comparison of currently widely used imaging technologies: swept-source ...
Simon P. Rothenbuehler   +6 more
doaj   +1 more source

Peripapillary choroidal vascularity of paediatric myopic eyes with peripapillary hyperreflective ovoid mass‐like structures

open access: yesActa Ophthalmologica, Volume 103, Issue 2, Page e94-e103, March 2025.
Abstract Purpose To assess the peripapillary choroidal vasculature in paediatric myopic patients with and without peripapillary hyperreflective ovoid mass‐like structures (PHOMS). Methods This prospective study includes 60 eyes of 60 myopic (spherical equivalent [SE] <−1.00 dioptre [D]) patients with (n = 30) and without (n = 30) PHOMS (PHOMS [+] and ...
Furkan Kirik   +6 more
wiley   +1 more source

Therapeutic potential of co-enzyme Q10 in retinal diseases [PDF]

open access: yes, 2017
Coenzyme Q10 (CoQ10) plays a critical role in mitochondrial oxidative phosphorylation by serving as an electron carrier in the respiratory electron transport chain.
Marcheggiani, Fabio   +6 more
core   +1 more source

Posterior Microphthalmos Pigmentary Retinopathy Syndrome [PDF]

open access: yes, 2023
Purpose: To report a case of a rare disease entity Posterior Microphthalmos Pigmentary Retinopathy Syndrome (PMPRS) in a 47-year-old female with a brief review of literature.
Mohideen KA, Syed   +4 more
core   +2 more sources

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