Results 141 to 150 of about 584,777 (259)

Optic Nerve Tumors: Diagnosis and Therapy

open access: yes
Powerppoint lecture covers a patient case, differential diagnosis, and optic nerve anatomy. Also includes examination information, fundus images and visual field defects. Presenting Symptom: Proptosis; Hemianopsia; Scotoma.
Alfredo A. Sadun, MD, PhD
core  

CXCL3 Antagonism Reverses Systemic Antitumor Immune Memory Impairment Associated With High Tumor Burden and Sensitizes Anti‐PD‐1 Therapy

open access: yesAdvanced Science, EarlyView.
This study reveals that large tumors secrete more chemokine CXCL3, which recruits immunosuppressive neutrophils to the periphery, thereby impairing the activation and memory of systemic tumor‑reactive CD8+ T cells. CXCL3 antagonism restores systemic immune memory and enhances the antitumor efficacy of anti‑PD‑1 therapy, offering a potential strategy to
Ji Wang   +15 more
wiley   +1 more source

Central serous papillopathy by optic nerve head drusen

open access: yes, 2010
Ana Marina Suelves1, Ester Francés-Muñoz1, Roberto Gallego-Pinazo1, Diamar Pardo-Lopez1, Jose Luis Mullor2, Jose Fernando Arevalo3, Manuel Díaz-Llopis1,4,51Department of Ophthalmology, La Fe University Hospital, Valencia,
Ester Francés-Muñoz   +3 more
core  

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

open access: yesAdvanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin   +13 more
wiley   +1 more source

Differences in optic nerve structure between individuals of predominantly African and European ancestry: Implications for disease detection and pathogenesis

open access: yes, 2008
Christopher A GirkinUniversity of Alabama at Birmingham School of Medicine, Birmingham, AL, USAAbstract: Glaucoma disproportionately affects individual of African ancestry. Additionally, racial differences in the optic nerve head have been well described
Christopher A Girkin
core  

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

open access: yesAdvanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Bibliometric mapping of the 100 most-cited publications on optic nerve and optic pathway glioma: A cross-sectional bibliometric analysis. [PDF]

open access: yesMedicine (Baltimore)
Shah MH   +7 more
europepmc   +1 more source

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