Results 151 to 160 of about 584,777 (259)

Optic nerve head analysis of superior segmental optic hypoplasia using Heidelberg retina tomography

open access: yes, 2010
Atsushi Miki1,2, Motohiro Shirakashi1, Kiyoshi Yaoeda1, Atsushi Fukushima1, Mineo Takagi1, Haruki Abe11Division of Ophthalmology and Visual Sciences, Niigata University Graduate School of Medical and Dental Sciences, Niigata, 2Department of Ophthalmology,
et al   +3 more
core  

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

open access: yesAdvanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir   +3 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

open access: yesAdvanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee   +5 more
wiley   +1 more source

Case of acute optic nerve compression caused by tuberculum sellae meningioma with optic canal involvement

open access: yes, 2012
Yuzhu Chai1, Hiroko Yamazaki1, Akihide Kondo2, Toshiyuki Oshitari3, Shuichi Yamamoto31Department of Ophthalmology, Kohnodai Hospital, National Center for Global Health and Medicine, Chiba, 2Department of Neurosurgery, Juntendo University, School
Yamazaki H   +4 more
core  

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

open access: yesAdvanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang   +5 more
wiley   +1 more source

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

open access: yesAdvanced Science, EarlyView.
Lactate and H4K12la are elevated in Parkinson's disease. Mechanistically, p300‐mediated H4K12la enrichment at the HIF‐1α promoter upregulates HIF‐1α, which represses Ndufs1, impairing mitochondrial respiration and energy homeostasis in DA neurons.
Yingyao Liu   +15 more
wiley   +1 more source

Minimally Invasive Versus Open Total and Distal Gastrectomy After Chemotherapy for Gastric Cancer: A Nationwide Observational Study

open access: yesAnnals of Gastroenterological Surgery, EarlyView.
This nationwide observational study used data from the National Clinical Database. Patients who underwent total or distal gastrectomy for gastric cancer after chemotherapy between January 2014 and December 2022 were included. Minimally invasive surgery was associated with lower incidences of overall postoperative complications of Clavien–Dindo grade ...
Nobuaki Hoshino   +8 more
wiley   +1 more source

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