Results 41 to 50 of about 584,777 (259)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

The contribution of brain reorganisation to recovery in patients with optic neuritis [PDF]

, 2010
In this thesis, the mechanisms of damage and repair in clinically isolated optic neuritis (ON) were investigated in vivo, by combining magnetic resonance imaging (MRI), electrophysiology and optical coherence tomography (OCT).
Jenkins, T.M.
core  

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Taking a close look at optic-nerve meningioma

Philippine Journal of Ophthalmology, 2004
MENINGIOMAS, the most common benign intracranial neoplasms, most often involve the visual pathways in the parasellar and orbital regions, with compression or infiltration of the optic nerves or chiasm.
Anthony C. Arnold, MD
doaj  

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Looking at Optic Nerve Sheath Meningiomas Through Genetics—From Clinic to Bench and Back Again

Frontiers in Bioscience-Scholar
Optic nerve sheath meningiomas (ONSMs) occupy a unique intersection between neuro-oncology and genetics. Although most cases arise in middle-aged women as solitary, slow-growing tumors, pediatric onset, bilateral disease, or rapid progression frequently ...
Marco Zeppieri, Fabiana D’Esposito, Caterina Gagliano, Marco Battista, Piero Barboni, Simonetta Gaia Nicolosi, Matteo Capobianco   +6 more
doaj   +1 more source

Accurate and reliable segmentation of the optic disc in digital fundus images [PDF]

, 2014
We describe a complete pipeline for the detection and accurate automatic segmentation of the optic disc in digital fundus images. This procedure provides separation of vascular information and accurate inpainting of vessel-removed images, symmetry-based ...
Giachetti, Andrea, Emanuele Trucco, Trucco, Emanuele; id_orcid, Lucia Ballerini, Ballerini, Lucia   +4 more
core   +1 more source

Correlation of optic nerve and optic nerve sheath diameter with intracranial pressure in pigs. [PDF]

, 2020
OBJECTIVE Several studies have shown an association between intracranial pressure and the diameter of the optic nerve sheath measured by transbulbar ultrasonography. To understand the pathophysiology of this phenomenon, we aimed to measure the changes
J. Beck (8399460), C. Fung (8399454), I. Zubak (8399445), S. M. Jakob (8399457), W. J. Z’Graggen (8399463), J Beck, Jakob, S. M., Zubak, I., A. Schuetz (8399448), R Mija, I Zubak, S M Jakob, Schuetz, A., Z'Graggen, W. J., C Fung, M Glas, A Schuetz, R. Mija (8399442), Fung, C., Beck, J., Glas, M., Andreas Bloch, Bloch, Andreas, Mija, R., Andreas Bloch (5489834), M. Glas (8399451), W J Z'Graggen   +26 more
core   +2 more sources

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong, Yuping Xiao, Yuhan Wu, Ziyuan Huang, Weishan Liang, Li Xiao, Yaqing Shu, Tingting Lu, Yanyu Chang, Wei Qiu, Yuge Wang   +10 more
wiley   +1 more source

Neuroophthalmological symptoms of pituitary adenomas with supraparasellar extension

Journal of Ophthalmology, 2019
Background: Pituitary adenomas (PA) are benign neoplasms that arise from adenohypophysis; they are most common skull base tumors, and account for 12% to15% of all intracranial tumors.
K.S. Iegorova, M.O. Guk, O.M. Guk, L.O. Danevych, D.M. Tsiurupa, A.O. Mumliev   +5 more
doaj   +1 more source