Results 71 to 80 of about 184,715 (310)

Optical mapping of neuronal activity during seizures in zebrafish [PDF]

, 2017
Mapping neuronal activity during the onset and propagation of epileptic seizures can provide a better understanding of the mechanisms underlying this pathology and improve our approaches to the development of new drugs.
Fornetto, C, M\ufcllenbroich, M. C, Mannaioni, G, Marchetto, Giulia, Masi, A, Pavone, F. S, Resta, F, Tiso, Natascia, Turrini, L, Vanzi, F., Vettori, Andrea   +10 more
core   +3 more sources

Long-read structural and epigenetic profiling of a kidney tumor-matched sample with nanopore sequencing and optical genome mapping

NAR Genomics and Bioinformatics
Carcinogenesis often involves significant alterations in the cancer genome, marked by large structural variants (SVs) and copy number variations (CNVs) that are difficult to capture with short-read sequencing.
Sapir Margalit, Zuzana Tulpová, Tahir Detinis Zur, Yael Michaeli, J. Deek, Gil Nifker, Rita Haldar, Y. Gnatek, Dorit Omer, Benjamin Dekel, H. Baris Feldman, Assaf Grunwald, Yuval Ebenstein   +12 more
semanticscholar   +1 more source

Chromosome-scale assembly and annotation of the perennial ryegrass genome

BMC Genomics, 2022
Background The availability of chromosome-scale genome assemblies is fundamentally important to advance genetics and breeding in crops, as well as for evolutionary and comparative genomics.
Istvan Nagy, Elisabeth Veeckman, Chang Liu, Michiel Van Bel, Klaas Vandepoele, Christian Sig Jensen, Tom Ruttink, Torben Asp   +7 more
doaj   +1 more source

Identification of an NF1 Microdeletion with Optical Genome Mapping

International Journal of Molecular Sciences, 2023
Neurofibromatosis type 1 (NF1) is a clinically heterogeneous neurocutaneous disorder inherited in autosomal dominant manner. Approximately 5–10% of the cases are caused by NF1 microdeletions involving the NF1 gene and its flanking regions. Microdeletions, which lead to more severe clinical manifestations, can be subclassified into four different types (
Gergely Büki, Anna Bekő, Csaba Bödör, Péter Urbán, Krisztina Németh, Kinga Hadzsiev, György Fekete, Hildegard Kehrer-Sawatzki, Judit Bene   +8 more
openaire   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Optical mapping of the Mycobacterium avium subspecies paratuberculosis genome

BMC Genomics, 2009
Background Infection of cattle with Mycobacterium avium subspecies paratuberculosis (M. ap) causes severe economic losses to the dairy industry in the USA and worldwide. In an effort to better examine diversity among M.
Schwartz David C, Zhou Shiguo, Schramm Timothy M, Wu Chia-wei, Talaat Adel M   +4 more
doaj   +1 more source

De novo assembly of the cattle reference genome with single-molecule sequencing. [PDF]

, 2020
BackgroundMajor advances in selection progress for cattle have been made following the introduction of genomic tools over the past 10-12 years. These tools depend upon the Bos taurus reference genome (UMD3.1.1), which was created using now-outdated ...
Bickhart, Derek M, Cole, John B, Couldrey, Christine, Dreischer, Christian, Elsik, Christine G, Ghurye, Jay, Hagen, Darren E, Hall, Richard, Hammond, John A, Hoffman, Jinna, Koren, Sergey, Li, Wenli, Liu, George, Low, Wai Y, McDaneld, Tara G, McKay, Stephanie D, Medrano, Juan F, Murdoch, Brenda M, Nandolo, Wilson, Phillippy, Adam M, Rhie, Arang, Rosen, Benjamin D, Rowan, Troy N, Schnabel, Robert D, Schroeder, Steven G, Schultheiss, Sebastian J, Schwartz, John C, Smith, Timothy PL, Snelling, Warren M, Thibaud-Nissen, Françoise, Tseng, Elizabeth, Van Tassell, Curtis P, Zimin, Aleksey   +32 more
core  

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing. [PDF]

, 2018
Sequencing technologies have undergone a paradigm shift from bulk to single-cell resolution in response to an evolving understanding of the role of cellular heterogeneity in biological systems.
Abate, Adam R, Demaree, Benjamin, Lan, Freeman, Weisgerber, Daniel   +3 more
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source