Results 51 to 60 of about 343,154 (297)

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Longitudinally continuous varying high-order cylindrical vector fields enabled by spin-decoupled metasurfaces

Nanophotonics
The manipulation of vector optical fields in three-dimensional (3D) space plays a vital role in both fundamental research and practical implementations of polarization optics.
He Xinye, Bao Hanlin, Zhang Fei, Kang Tongtong, Pu Mingbo, Chen Yan, Guo Yinghui, Gong Jintao, Xu Mingfeng, Luo Xiangang   +9 more
doaj   +1 more source

Low Altitude UAV Detection in Complex Contexts

IEEE Access
With the rapid development of drone technology and its widespread application in various fields, low-altitude drone detection has become an important technological approach for ensuring public safety and implementing effective supervision.
Zhengwei Tang, Wen Lu, Weihua Tang, Dong He, Yongmei Huang, Qiang Wang   +5 more
doaj   +1 more source

Orbital Angular Momentum Waves: Generation, Detection and Emerging Applications

, 2019
Orbital angular momentum (OAM) has aroused a widespread interest in many fields, especially in telecommunications due to its potential for unleashing new capacity in the severely congested spectrum of commercial communication systems.
Chen, Rui, Li, Jiandong, Moretti, Marco, Wang, Xiaodong, Zhou, Hong   +4 more
core   +1 more source

Nonlinear Polarization Manipulation in Optical Fibers [PDF]

Frontiers in Optics 2015, 2015
We describe a phenomenon of self-organization of the light state-of-polarization in optical fibers based on a nonlinear cross-polarization interaction between an incident signal and its backward replica. Several proof-of-principles for telecom applications are reported.
Bony, Pierre Yves, GUASONI, Massimiliano, Gilles, Marin, Picozzi, Antonio, Pitois, Stéphane, Millot, Guy, WABNITZ, Stefan, Fatome, Julien   +7 more
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Dynamic nonlocal metasurface for multifunctional integration via phase-change materials

Nanophotonics
Non-local metasurface supporting geometric phases at bound states in the continuum (BIC) simultaneously enables sharp spectral resonances and spatial wavefront shaping, thus providing a diversified optical platform for multifunctional devices. However, a
Yu Shilin, Xu Mingfeng, Pu Mingbo, Tang Xi, Zheng Yuhan, Guo Yinghui, Zhang Fei, Li Xiong, Ma Xiaoliang, Luo Xiangang   +9 more
doaj   +1 more source

Orbital angular momentum 25 years on [invited] [PDF]

, 2017
Twenty-five years ago Allen, Beijersbergen, Spreeuw, and Woerdman published their seminal paper establishing that light beams with helical phase-fronts carried an orbital angular momentum. Previously orbital angular momentum had been associated only with
Padgett, Miles J.
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source