Results 51 to 60 of about 2,161,602 (286)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Chemically Reactive Thin Films: Dynamics and Stability

Advanced Materials Interfaces
Catalyst particles or complexes suspended in liquid films can trigger chemical reactions leading to inhomogeneous concentrations of reactants and products in the film.
Tilman Richter, Paolo Malgaretti, Thomas M. Koller, Jens Harting   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Calcined Solution-Based PVP Influence on ZnO Semiconductor Nanoparticle Properties

Crystals, 2017
A water-based solution of polyvinylpyrrolidone (PVP) at various concentrations and zinc nitrates were used in conjunction with calcination to produce zinc oxide semiconductor nanoparticles.
Halimah Mohamed Kamari, Naif Mohammed Al-Hada, Elias Saion, Abdul Halim Shaari, Zainal Abidin Talib, Moayad Husein Flaifel, Abdullah Ahmed Ali Ahmed   +6 more
doaj   +1 more source

Optical properties of mesoporous photonic crystals, filled with dielectrics, ferroelectrics and piezoelectrics [PDF]

Journal of Advanced Dielectrics, 2017
At present, it is very important to create new types of mirrors, nonlinear light frequency transformers and optical filters with controlled optical properties. In this connection, it is of great interest to study photonic crystals.
V. S. Gorelik, Dongxue Bi, Guang Tao Fei
doaj   +1 more source

Optical properties of bialkali photocathodes

, 2004
The optical properties of the `bialkali' KCsSb and RbCsSb photomultiplier cathodes have been experimentally investigated in the visible range. The measurements carried out include the absolute reflectance at near-normal incidence, the polarization ...
Alimonti, Boger, Born, Buck, D. Motta, Eguchi, Heavens, Lay, Lay, Nakahata, Raghavan, S. Schönert, Timan, Tompkins, Weber   +14 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Optical properties of metal nanoparticles with arbitrary shapes

, 2003
We have studied the optical properties of metallic nanoparticles with arbitrary shape. We performed theoretical calculations of the absorption, extinction and scattering efficiencies, which can be directly compared with experiments, using the Discrete ...
Barrera, R. G., Noguez, Cecilia, Sosa, Ivan   +2 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Particle size tuning in silver-polyacrylonitrile nanocomposites

eXPRESS Polymer Letters, 2010
Silver-polyacrylonitrile (Ag-PAN) nanocomposites were in situ synthesized by simultaneous polymerization of acrylonitrile and reduction of silver ions, starting from mixtures of silver nitrate (AgNO3), acrylonitrile (AN), and UV photoinitiator (IN).
doaj   +1 more source