Results 61 to 70 of about 7,998,648 (308)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

open access: yesFEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Controls on Ocean Color Spectra Observed During the North Atlantic Aerosols and Marine Ecosystems Study (NAAMES)

open access: yesFrontiers in Marine Science, 2020
Satellite ocean color remote sensing is the primary method to retrieve synoptic measurements of the optical properties of the ocean on large spatial and regular time scales.
James G. Allen   +3 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Numerical simulations of beam propagation through optical turbulence for high-altitude platform crosslinks [PDF]

open access: yes, 2004
In this paper we introduce a simulation method for modelling clear-air atmospheric turbulence effects for long horizontal stratospheric paths. Divergence angles of several hundred microradians in combination with link distances up to 800 km require to ...
Perlot, Nicolas   +3 more
core  

Enhancement of optical absorption in Ga-chalcopirite-based intermediate-band materials for high efficiency solar cells [PDF]

open access: yes, 2010
We present absorption properties enhancement for two CuGaS2-based intermediate-band materials, as promising compounds for high efficiency, lower-cost photovoltaic devices.
P. Wahnón   +5 more
core   +1 more source

Study of Optical Properties of HgTe Films

open access: yesIraqi Journal of Physics, 2008
Alloy of (HgTe) has been prepared succesful in evacuated qurtz ampoule at pressure 4×10-5torr, and melting temperature equal to 823K for five days. Thin films of HgTe of thickness 1μm were deposited on NaCl crystal by thermal evaporation technique at ...
Kadhim A. Adem
doaj  

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Estimating specific inherent optical properties of tropical coastal waters using bio-optical model inversion and in situ measurements: case of the Berau estuary, East Kalimantan, Indonesia [PDF]

open access: yes, 2010
Specific inherent optical properties (SIOP) of the Berau coastal waters were derived from in situ measurements and inversion of an ocean color model. Field measurements of water-leaving reflectance, total suspended matter (TSM), and chlorophyll a (Chl a)
C. M. Mannaerts   +8 more
core   +1 more source

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