Results 91 to 100 of about 208,937 (301)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 1993 Optimization of microbial death, enzyme inactivation and vitamin C retention during pasteurization of pH-adjusted orange juice is discussed free of equipment-dependent parameters such as the heating lag.
Özilgen, Mustafa, Ülgen, Neşe
core +1 more source
A Novel In Vitro Model for Determining the Optimum pH and Dose Volume of New Liquid Alginate for Infant Reflux Suppression. [PDF]
Drugs R D, 2021 Fisher J +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Penentuan pH optimum untuk pertumbuhan kepiting bakau Scylla serrata dalam wadah terkontrol
, 2016 One of the abiotic factors that affects the growth and the survival of crabs is pH. The optimum pH media will give maximum impact on mangrove crabs because it is related with the osmoregulation process. This study aimed to examine the effect of pH on the
Affandi, Ridwan +7 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Scope of asymmetries in the Euro area. NBB Working Paper No. 37, March 2003 [PDF]
, 2003 We discuss the scope of asymmetries in growth and inflation developments in the euro area countries, taking the euro area as the natural benchmark since the establishment of EMU. We start with a descriptive analysis of a set of indicators that can give a
Moës, Ph., Ide, S.
core
OPTIMASI pH DAN WAKTU KONTAK OPTIMUM ADSORBEN Fe3O4-AH TERHADAP ION LOGAM Pb2+
, 2023 Optimization of pH and optimum contact time of coated magnetite adsorbent (Fe3O4-AH) against metal ions Pb2+ has been carried out. Humic acid-coated magnetite adsorbent (Fe3O4-AH) was prepared using the coprecipitation method with a mass ratio of 1:2 (w ...
Sari, Ika Yekti Liana +2 more
core
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source