Results 81 to 90 of about 43,018 (315)

Materials and System Design for Self‐Decision Bioelectronic Systems

Advanced Materials, EarlyView.
This review highlights how self‐decision bioelectronic systems integrate sensing, computation, and therapy into autonomous, closed‐loop platforms that continuously monitor and treat diseases, marking a major step toward intelligent, self‐regulating healthcare technologies.
Qiankun Zeng, Hong Liu, Yongheng Zhang, Youbin Zheng, Xuyin Ding, Mengni Zhu, Guoyue Shi, Yan Wang, Hossam Haick, Min Zhang   +9 more
wiley   +1 more source

Neural reactivations during sleep determine network credit assignment. [PDF]

, 2017
A fundamental goal of motor learning is to establish the neural patterns that produce a desired behavioral outcome. It remains unclear how and when the nervous system solves this 'credit assignment' problem.
Bodepudi, Anitha, Ganguly, Karunesh, Gulati, Tanuj, Guo, Ling, Ramanathan, Dhakshin S   +4 more
core   +3 more sources

Serotonergic System‐Targeted Nucleic Acid Hydrogel Coordinates Excitability Restoration and Circuit Reconstruction for Spinal Cord Injury Therapy

Advanced Materials, EarlyView.
The study reports a DNA/RNA heteroduplex hydrogel (SeroPTEN‐CG) that undergoes DNase‐mediated hydrogel‐to‐nanogel transition for spinal cord injury therapy by targeting the serotonergic system, combining 5‐hydroxytryptamine (5‐HT)‐mediated excitability restoration to reactivate dormant interneurons with phosphatase and tensin homolog (PTEN)‐targeted ...
Chunlin Li, Xiaoqing Zhao, Kai Jiang, Haixia Kang, Shuo Liu, Linlin Jiang, Baoshuai Bai, Haonan Cui, Ziyang Zhang, Menglei Dong, Ruizhi Zhang, Chenbo Zou, Shenghui Shang, Chi Zhang, Xiangchuang Fan, Lijuan Zhu, Huiquan Duan, Chuan Zhang, Shiqing Feng, Hengxing Zhou   +19 more
wiley   +1 more source

Optogenetics [PDF]

Nature Methods, 2010
Tooru M. Mizuno, Ashwini Padhi, Naomi Fineberg, Naomi A. Fineberg, Ashwini Padhi, Michael H. Bloch, James F. Leckman, Ashwini Padhi, Naomi A. Fineberg, Rick A. Bevins, Matthew I. Palmatier, Cécile Viollet, Jacques Epelbaum, Daniel Hoyer, Istvan Bitter, Marie-Louise G. Wadenberg, Andrea Bari, Catherine Belzung, Brian L. Odlaug, Jon E. Grant, Marc N. Branch, Marc N. Branch, David S. Tait, Verity J. Brown, David C. S. Roberts, Luis Stinus, Stéphanie Caillé, Martine Cador, Michael M. Morgan, MacDonald J. Christie, Michael M. Morgan, MacDonald J. Christie, Linda Dykstra, Brian L. Odlaug, Jon E. Grant, Annemarie Unger, Gabriele Fischer, Gabriele Fischer, Annemarie Unger, MacDonald J. Christie, Michael M. Morgan, Giovanni Hernandez, Peter Shizgal, Luis de Lecea, Jason C. G. Halford, Istvan Bitter, Gorkem Yararbas, Sakire Pogun, Daniel Hoyer, Holden D. Brown, Michael E. Ragozzino, Luis Stinus, Stéphanie Caillé, Martine Cador, Helen J. Cassaday, Trevor W. Robbins, Lance R. McMahon, Naheed (Max) Mirza, Trevor W. Robbins, Trevor W. Robbins, Martine Cador, Naheed (Max) Mirza, Paul D. Callaghan, Iain S. McGregor, Murray R. Thompson   +64 more
openaire   +3 more sources

Optogenetics and Its Transformative Role in Tissue Engineering and Regenerative Medicine

Nano Select
Optogenetics, a revolutionary technique leveraging light stimulation for precise cellular control, holds immense potential in regenerative medicine. Offering unparalleled spatial and temporal accuracy, the entrance of optogenetics into tissue engineering
Emine Camcıoglu, Deniz Ghasemi Mohammadrezaloo, Bircan Dinc   +2 more
doaj   +1 more source

Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits [PDF]

, 2016
Cortico-basal ganglia-thalamic (CBT) neural circuits are critical modulators of cognitive and motor function. When compromised, these circuits contribute to neurological and psychiatric disorders, such as Parkinson's disease (PD).
Bucklin, Mark, Han, Xue, Kondabolu, Krishnakanth, Kopell, Nancy, McCarthy, Michelle M., Roberts, Erik A.   +5 more
core   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

MRI-guided robotic arm drives optogenetic fMRI with concurrent Ca2+ recording

Nature Communications, 2019
Fiber optic implantation in deep areas of the rodent’s brain for MRI combined with optogenetics is challenging. Here the authors use an MRI-guided robotic arm as the navigation method for accurate fiber optic placement and precise microinjection during ...
Yi Chen, Patricia Pais-Roldan, Xuming Chen, Michael H. Frosz, Xin Yu   +4 more
doaj   +1 more source

Optogenetics: Therapeutic spark in neuropathic pain

Biomolecules & Biomedicine, 2019
Optogenetics is an emerging field, which uses light and molecular genetics to manipulate the activity of live cells by expressing light-sensitive proteins.
Kang Liu, Long Wang
doaj   +1 more source

Rodent models for the analysis of tissue clock function in metabolic rhythms research [PDF]

, 2017
The circadian timing system consists on a distributed network of cellular clocks that together coordinate 24-h rhythms of physiology and behavior. Clock function and metabolism are tightly coupled, from the cellular to the organismal level.
Astiz, Mariana, Leinweber, Brinja, Oster, Henrik, Tsang, Anthony H.   +3 more
core   +2 more sources