Results 71 to 80 of about 1,674 (204)

Emergence of optrA-Mediated Linezolid Resistance in Enterococcus faecium: A Molecular Investigation in a Tertiary Hospital of Southwest China from 2014–2018

Infection and Drug Resistance, 2022
Miao Yi,1 Jiaqi Zou,2 Jinxin Zhao,1 Yu Tang,3 Yaling Yuan,1 Bingxue Yang,1 Jinzhu Huang,1 Peiwen Xia,1 Yun Xia1 1Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of China ...
Yi M, Zou J, Zhao J, Tang Y, Yuan Y, Yang B, Huang J, Xia P, Xia Y   +8 more
doaj  

Antibiotic resistance mediated by site‐specific mutations in the multidrug efflux transporter CmeB of zoonotic pathogen Campylobacter

mLife, Volume 5, Issue 1, Page 83-98, February 2026.
Abstract The resistance‒nodulation‒division (RND) family of multidrug efflux transporters is widely distributed in Gram‐negative bacteria. Although their roles in mediating antibiotic resistance have been well known, our understanding of how they are altered to augment bacterial adaptation to antibiotic selection remains at an infancy stage.
Xiaolong Lin, Mengyu Zhao, Jianhong Gan, Haozheng Li, Min He, Fang Yang, Renqiao Wen, Tiejun Zhang, Quan Zhou, Ke Wu, Jinpeng Li, Chengyao Hou, Yang Cao, Hongning Wang, Yizhi Tang   +14 more
wiley   +1 more source

Detection of Genes Related to Linezolid Resistance (poxtA, cfr, and optrA) in Clinical Isolates of Enterococcus spp. from Humans: A First Report from Iran

Advanced Biomedical Research, 2023
Background: Enterococci may develop resistance to linezolid through chromosomal mutations that involve specific linezolid resistance genes, such as cfr, optrA, and poxtA.
Majid Torabi, Jamshid Faghri, Farkhondeh Poursina   +2 more
doaj   +1 more source

Comparative Genomics and Virulence Mechanisms to Identify Genes Related to Mucin O‐Glycan Degradation and Pathogenicity in a Potentially Multidrug‐Resistant Clostridium tertium Strain

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
The comparative genomic analysis provides information about how C. tertium HGMC01 strain cause disease through mucin glycan degradation, colonization, multidrug resistance, and modulation of immune responses. Moreover, this analysis data suggest that this strain interacts with host cells by degrading mucin in the gut, potentially through recognition or
Seonghun Kim, Ji Young Kang, Jung‐Sook Lee   +2 more
wiley   +1 more source

Impacts of florfenicol on the microbiota landscape and resistome as revealed by metagenomic analysis. [PDF]

, 2019
BACKGROUND:Drug-resistant fish pathogens can cause significant economic loss to fish farmers. Since 2012, florfenicol has become an approved drug for treating both septicemia and columnaris diseases in freshwater fish.
Liao, Chao, Terhune, Jeffery, Wang, Luxin, Zeng, Qifan   +3 more
core  

Identification of Outer Membrane Vesicles as a New Vehicle Mediating Antibiotic Resistance Gene Transfer in Campylobacter

Journal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
ABSTRACT The emergence and worldwide dissemination of antibiotic resistance genes (ARGs) compromise antibiotic therapy and are a major public health crisis. Horizontal gene transfer (HGT) plays a major role in the spread of ARGs among bacterial pathogens.
Mengyu Zhao, Min He, Xiaolong Lin, Ke Wu, Fang Yang, Xinggui Chen, Haozheng Li, Hongning Wang, Yizhi Tang   +8 more
wiley   +1 more source

Enterococcal isolates carrying the novel oxazolidinone resistance gene optrA from hospitals in Zhejiang, Guangdong, and Henan, China, 2010–2014 [PDF]

Clinical Microbiology and Infection, 2015
A collection of 1159 enterococcal isolates from five Chinese hospitals were screened for the presence of the novel oxazolidinone resistance gene optrA, which was found in 34 (2.9%) isolates. Pulsed-field gel electrophoresis (PFGE) typing of 29 optrA-carrying Enterococcus faecalis isolates revealed 25 PFGE patterns, and multilocus sequence typing ...
Cai, J., Wang, Y., Schwarz, S., Lv, H., Li, Y., Liao, K., Yu, S., Zhao, K., Gu, D., Wang, X., Zhang, R., Shen, J.   +11 more
openaire   +2 more sources

Antibiotic Resistance: A Genetic and Physiological Perspective

MedComm, Volume 6, Issue 11, November 2025.
The development of resistance to antimicrobials and their historical progression are depicted in this graphic. It draws attention to important biochemical, physiological, and genetic factors that contribute to AMR, such as the transmission of genes, the development of biofilms, and the inactivation of antibiotics.
Rania G. Elbaiomy, Ahmed H. El‐Sappah, Rong Guo, Xiaoling Luo, Shiyuan Deng, Meifang Du, Xiaohong Jian, Mohammed Bakeer, Zaixin Li, Zhi Zhang   +9 more
wiley   +1 more source

Genomic epidemiology reveals multiple mechanisms of linezolid resistance in clinical enterococci in China

Annals of Clinical Microbiology and Antimicrobials
Background Infections caused by linezolid-resistant enterococci (LRE) are clinically difficult to treat and threaten patient health. However, there is a lack of studies on long time-span LRE strains in China.
Ziran Wang, Danping Liu, Jingjia Zhang, Lingli Liu, Zeming Zhang, Chang Liu, Songnian Hu, Linhuan Wu, Zilong He, Hongli Sun   +9 more
doaj   +1 more source

Spatio‐temporal characteristics of the gastrointestinal resistome in a cow‐to‐calf model and its environmental dissemination in a dairy production system

iMeta, Volume 4, Issue 4, August 2025.
This study revealed spatio‐temporal characteristics of gastrointestinal resistome in a cow‐to‐calf model and the pattern of their spread to the environment and offspring in the dairy production system. The gastrointestinal tract of dairy cows is a natural reservoir of resistomes and distinguished by gut sites and regions.
Shuai Liu, Yimin Zhuang, Tianyu Chen, Duo Gao, Jianxin Xiao, Jinfeng Wang, Jinghui Li, Xinjie Zhao, Rong Peng, Wenli Guo, Jialin Wei, Mo Sha, Jingjun Wang, Jiaying Ma, Mei Ma, Mengmeng Li, Wei Wang, Ya‐Jing Wang, Shengli Li, Zhijun Cao   +19 more
wiley   +1 more source