Results 101 to 110 of about 204,843 (353)

Reason for screening and methods of diagnosing type II diabetes mellitus [PDF]

, 1995
The aim of this study was to assess the reasons for screening and the methods of diagnosing Type II diabetic patients. It was a retrospective analysis of patients attending the Ap Lei Chan Clinic of the General Practice Unit of the University of Hong ...
Lam, TP
core  

The FOXC2‐LAMA4 Axis Orchestrates Vasculogenic Mimicry and Immunosuppressive Niche Formation to Drive Metastatic Cascade in Renal Cell Carcinoma

Advanced Science, EarlyView.
Advanced clear cell renal cell carcinoma metastasis is driven by a FOXC2+ tumor subpopulation. These cells execute vasculogenic mimicry for dissemination and secrete LAMA4. LAMA4 engages macrophage ITGA6, activating the STAT6/GATA3 axis to polarize macrophages into a pro‐metastatic, immunosuppressive phenotype.
Jiaxi Yao, Tong Xu, Chengyuan Wang, Chenyuan Wang, Junfeng Xie, Rui Zheng, Ke Wang, Xingzuo Jiang, Zewei Hu, Hongwei Jing, Lin Li, Tao Liu   +11 more
wiley   +1 more source

Clinical and genetic characteristics of abnormal glucose tolerance in Japanese women in the first year after gestational diabetes mellitus

Journal of Diabetes Investigation, 2019
Aims/Introduction Risk factors of type 2 diabetes mellitus in Japanese women with recent gestational diabetes mellitus are unknown. The objective of the present study was to investigate the clinical and genetic characteristics associated with postpartum ...
Yoshifumi Kasuga, Kei Miyakoshi, Atsushi Tajima, Yoshifumi Saisho, Satoru Ikenoue, Daigo Ochiai, Tadashi Matsumoto, Naoko Arata, Kenichiro Hata, Mamoru Tanaka   +9 more
doaj   +1 more source

Contrasting actions of ginsenosides Rb1 and Rg1 on glucose tolerance in rats

Chinese Journal of Physiology, 2019
Ginsenoside profile of Panax ginseng is changing with season and cultivated soil. Yet, dose-response relationship of main ginsenosides on metabolic measures has not been documented in vivo.
Rungchai Chaunchaiyakul, Naruemon Leelayuwat, Jin-Fu Wu, Chih-Yang Huang, Chia-Hua Kuo   +4 more
doaj   +1 more source

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Diabetes and hypertension in urban bhutanese men and women

Indian Journal of Community Medicine, 2013
Background: Bhutan is a mountainous country with 31% urban population. There is no information on prevalence of diabetes and hypertension in Bhutan yet. This was the first study of its kind conducted in the capital city.
Bhakta Raj Giri, Krishna Prasad Sharma, Rup Narayan Chapagai, Dorji Palzom   +3 more
doaj   +1 more source

Toxicology and Oral glucose Tolerance Test (OGTT) of Thai Medicinal Plant Used for Diabetes controls, Phyllanthus acidus L. (EUPHORBIACEAE) [PDF]

, 2016
Napapach Chaimum-aom, Sanong Chomko, Chusri Talubmook   +2 more
openalex   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

The Gut Commensal Butyricimonas Virosa Modulates Gut Microbiota‐Dependent Thiamine Metabolism and Attenuates Mouse Steatotic Liver Disease

Advanced Science, EarlyView.
This study reveals that dietary stachyose enriches Butyricimonas virosa, effectively attenuating metabolic dysfunction‐associated steatotic liver disease (MASLD). Mechanistically, B. virosa enhances gut thiamine monophosphate synthesis, which elevates hepatic thiamine pyrophosphate levels.
Ningning He, Haoyu Wang, Zizhen Yang, Hui Li, Bei Liu, Kaiwei Chen, Zhinan Wu, Xinnan Zhao, Hewei Liang, Mengmeng Wang, Xiaofang Li, Yiyi Zhong, Haifeng Zhang, Liang Xiao, Karsten Kristiansen, Jixing Peng, Yuanqiang Zou, Shangyong Li   +17 more
wiley   +1 more source

Metabolic response to oral glucose tolerance test performed in neutral and warm environmental temperature

International Journal of Hyperthermia, 2019
Objective: Hot environments are associated with impaired glucose metabolism at rest in healthy humans. The purpose of this study was to explore the contribution of key glucoregulatory hormones and biomarkers to this altered glucose tolerance.
Sophie Antoine-Jonville, Dalia El Khoury, Cécile Faure, Keyne Charlot, Olivier Hue, Marie-Dominique Hardy-Dessources   +5 more
doaj   +1 more source