Results 41 to 50 of about 1,639,464 (252)

Primary mucosal melanoma: A case report

Journal of Craniomaxillofacial Research, 2017
Malignant melanoma is an aggressive malignancy of melanocytes affecting both skin and mucosa. Primary oral melanoma occurs 0.2-8% of all melanomas and accounts for 0.5% of all oral malignancies.
Fereshteh Baghai, Sedigheh Rahrotaban, Ata Garajei, Fatemeh Pirzadeh, Samira Derakhshan   +4 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Uncommon clinical presentation of oral malignant melanoma

Beni-Suef University Journal of Basic and Applied Sciences, 2018
Malignant melanoma is one of the most lethal skin cancer due its high capability for metastasis. Its incidence has shown a dramatic increase over the past few decades.
Maha M Mahmoud, Marwa Madi, Raneem Gamal
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Primary dermal melanoma in a patient with a history of multiple malignancies: a case report with molecular characterization [PDF]

, 2013
Introduction: Primary dermal melanoma (PDM) is a recently described clinical entity accounting for less than 1% of all melanomas. Histologically, it is located in the dermis or subcutaneous tissue, and it shows no connections with the overlying epidermis.
Palomba, Grazia, Marcello Gulino, Sini, Germana, Maria Colombino, Maxia, Sara, Grazia Palomba, Palmieri, Giuseppe, Cossu, Antonio, Germana Sini, Paliogiannis, Panagiotis, Giuseppe Palmieri, Lissia, Amelia, Rubino, Corrado, Gulino, Marcello, Panagiotis Paliogiannis, Amelia Lissia, Antonio Cossu, Colombino, Maria, Sara Maxia, Corrado Rubino   +19 more
core   +1 more source

ORAL MELANOMA: WHAT DOES THE DENTIST NEED TO KNOW?

Revista Naval de Odontologia On Line
Oral melanoma is a malignant neoplasm of melanocytes, characterized by aggressive behavior and an extremely poor prognosis. Melanomas in the oral cavity are rare and are usually diagnosed at an advanced stage, reducing ...
Gabriel Bassan Marinho Maciel, Taline Laura Guse   +1 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Malignancy without immortality? Cellular immortalization as a possible late event in melanoma progression [PDF]

, 2011
P>Cell senescence is a permanent growth arrest following extended proliferation. Cultured cancer cells including metastatic melanoma cells often appear immortal (proliferate indefinitely), while uncultured benign nevi (moles) show senescence markers ...
Marais, R., Marais, R, Bennett, DC, Julia K. Soo, Chow, J, Hill, L, Chow, J., Ross, ADM, W. Nicol Keith, MacKenzie Ross, A.D., Hossain, M., Bennett, D.C., Heung Chong, W, Hoare, S, Mehnaz Hossain, Soo, JK, Dorothy C. Bennett, Rebecca S. Collinson, Carla Milagre, Milagre, C., David M. Kallenberg, Lucy Hill, Collinson, RS, Mackenzie Ross, AD, Hill, L., Chong, WH, Richard Marais, Kallenberg, DM, Soo, J.K., Jade Chow, Keith, W.N., Hossain, M, Heung Chong, W., Hoare, S., Stacey Hoare, Kallenberg, D.M., Milagre, C, W. Heung Chong, Collinson, R.S., Keith, WN, Alastair D. MacKenzie Ross   +40 more
core   +1 more source

A Review of the Aetiopathogenesis and Clinical and Histopathological Features of Oral Mucosal Melanoma

The Scientific World Journal, 2017
Oral mucosal melanoma is an uncommon, usually heavily melanin-pigmented, but occasionally amelanotic aggressive tumour with a poor prognosis. Despite radical surgery, radiotherapy, or chemotherapy, local recurrence and distant metastasis are frequent ...
Liviu Feller, Razia A. G. Khammissa, Johan Lemmer   +2 more
doaj   +1 more source

Is focal melanotic lesion potentially malignant? A case report

Journal of Taibah University Medical Sciences, 2018
الملخص: الميلانوما هي آفة خبيثة تصيب الخلايا المنتجة للميلانين التي تُرى غالباً في الجلد. وهي تنبع من السلائف المصطبغة عند ٣٥-٥٠٪ من الحالات. مع أن التصبغ الميلانيني في الفم كثير الحدوث، ولكن سرطان الخلايا المنتجة للميلانين كالميلانوما نادر الحدوث.
Astha Chaudhry, MDS, Pulin Saluja, MDS, Muniraju Manjunath, MDS   +2 more
doaj   +1 more source