Results 31 to 40 of about 1,639,464 (252)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

PAX2 regulates ADAM10 expression and mediates anchorage-independent cell growth of melanoma cells [PDF]

, 2011
PAX transcription factors play an important role during development and carcinogenesis. In this study, we investigated PAX2 protein levels in melanocytes and melanoma cells by Western Blot and immunofluorescence analysis and characterized the role of ...
Ungerer Christopher, Hardt, Katja, Kai Doberstein, Hardt Katja, Pfeilschifter, Josef (Prof. Dr.), Lee Sophia Boyoung, Mihic-Probst Daniela, Mihic-Probst, D, Ungerer, Christopher, Mittelbronn, Michel, Mittelbronn, Michel Guy André, Bürger Claudia, Gutwein, P, Gutwein, Paul, Wolf-Henning Boehncke, Wieland, A, Sophia Boyoung Lee, Pfeilschifter, J, Josef Pfeilschifter, Baumgarten Peter, Paul Gutwein, Hardt, K, Pfeilschifter, Josef M., Michel Mittelbronn, Lee, Sophia Boyoung, Daniela Mihic-Probst, Claudia Bürger, Anja Wieland, Gutwein Paul, Wieland Anja, Baumgarten, Peter, Katja Hardt, Doberstein, K, Lee, S B, Peter Baumgarten, Baumgarten, P, Doberstein Kai, Mittelbronn Michel, Boehncke, Wolf-Henning, Ungerer, C, Doberstein, Kai, Boehncke Wolf-Henning, Wieland, Anja, Boehncke, W H, Bürger, Claudia, Bürger, C, Christopher Ungerer, Mittelbronn, M, Mihic-Probst, Daniela, Pfeilschifter Josef   +49 more
core   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Melanoma [PDF]

, 2012
Melanoma is a relatively common neoplasm which is increasing in incidence. Melanoma appears as a variegated irregular maculopapular lesion usually on the skin, but possibly on mucosae, conjunctiva, orbit, nails and oesophagus. They may be black, brown,
Magri, Stephanie, Pace, Keith
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Survival and prognostic factors in mucosal melanomas of the oral cavity: A meta-analysis [PDF]

Journal of Dental Research, Dental Clinics, Dental Prospects
Background. The development of early metastases due to the high vascularization and lymphatic drainage of the oral cavity, followed by delayed diagnosis, results in a worse prognosis of oral melanomas. The present study aimed to determine the survival of
Alberto Rodriguez-Archilla, Pablo Valverde-Martinez   +1 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Melanoma amelanótico oral em cão jovem: Relato de caso

, 2017
A cavidade oral é bastante acometida por neoplasias e corresponde ao quarto local mais frequente em pequenos animais. O melanoma é uma neoplasia maligna caracterizada com muita ou pouca produção de melanina, tendo o último um comportamento mais agressivo.
Mariela Sousa Gomes, Marcelo Campos Rodrigues, Mayara Irene Moreira, Alexandra de Siqueira Cajado Liarte, Bruno Martins Araújo, Francisco Lima Silva, Marllos Henrique Vieira Nunes   +6 more
core   +1 more source

Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1. [PDF]

, 2012
Melanoma is an often fatal form of skin cancer which is remarkably resistant against radio- and chemotherapy. Even new strategies that target RAS/RAF signaling and display unprecedented efficacy are characterized by resistance mechanisms.
Berking, Carola, Senft Daniela, Robert Besch, Carola Berking, Saskia A Graf, Claudia Kammerbauer, Thomas Ruzicka, Graf, Saskia A., Besch, Robert, Graf Saskia A., Senft, Daniela, Berking Carola, Kammerbauer, Claudia, Daniela Senft, Besch Robert, Kammerbauer Claudia, Ruzicka, Thomas, Saskia A. Graf, Ruzicka Thomas   +18 more
core   +2 more sources