Results 41 to 50 of about 1,597,894 (263)

Candida albicans enhances iron uptake to maintain fluconazole resistance

Infection and Immunity
Widespread use of fluconazole has led to the emergence of fluconazole-resistant (FR) Candida spp. causing challenges in clinical treatment. Iron, an essential nutrient, affects the levels of ergosterol (a fluconazole target) in fungal membranes.
Rishabh Sharma, Anubhav Nahar, Sumant Puri   +2 more
doaj   +1 more source

The Microbiome of Oral Squamous Cell Carcinomas: a Functional Perspective

, 2019
Purpose of Review: This decade has witnessed increasing interest in the potential role of the oral microbiome in head and neck cancers, particularly oral squamous cell carcinoma (OSCC).
Al-Hebshi, NN, Borgnakke, WS, Johnson, NW   +2 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Candidalysin activates innate epithelial immune responses via epidermal growth factor receptor

Nature Communications, 2019
Candida albicans is an opportunistic fungus primarily affecting immunocompromised patients. Here, the authors identify a novel mechanism of host immune stimulation and highlight candidalysin and EGFR signalling components as potential targets for ...
Jemima Ho, Xuexin Yang, Spyridoula-Angeliki Nikou, Nessim Kichik, Andrew Donkin, Nicole O. Ponde, Jonathan P. Richardson, Remi L. Gratacap, Linda S. Archambault, Christian P. Zwirner, Celia Murciano, Rhonda Henley-Smith, Selvam Thavaraj, Christopher J. Tynan, Sarah L. Gaffen, Bernhard Hube, Robert T. Wheeler, David L. Moyes, Julian R. Naglik   +18 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Research progress on the relationship between orthodontic treatment and the oral microbiome

口腔疾病防治, 2022
With the deepening of research in oral microbiomics, an important relationship between changes in the oral microbiome and orthodontic treatment has been found. Orthodontic treatment will have an impact on the oral and systemic microbiome. The presence of
HUANG Xinliang, YAN Jiarong, HUA Fang, HE Hong   +3 more
doaj   +1 more source

Microbiome and Cancer in the Oral Cavity: A Bioinformatics Perspective [PDF]

The relationship between microbiome and cancer in the oral cavity has been under intense scrutiny over the past decade due to the advancement in next-generation sequencing.
Ming-Lun Hsu, Ding-Han Wang, Yu-Cheng Lin, Cheng-Chieh Yang   +3 more
core   +1 more source

Chemoradiation therapy changes oral microbiome and metabolomic profiles in patients with oral cavity cancer and oropharyngeal cancer

, 2021
Background: Patients with oral cavity cancer (OCC) and oropharyngeal cancer (OPC) are often seen with locoregionally advanced disease requiring complex multimodality treatments.
Yenkai Lim, Mark Morrison, Chamindie Punyadeera, Totsika, Makrina, Kenny, Liz, Avinash V. Karpe, Makrina Totsika, Punyadeera, Chamindie, Liz Kenny, Tang, Kai Dun, Karpe, Avinash V, Morrison, Mark, Lim, Yenkai, David J. Beale, Beale, David J, Kai Dun Tang   +15 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source