Results 41 to 50 of about 8,213 (256)

Bifidobacterium Pseudolongum‐Derived Inosine Mitigates Polystyrene Nanoplastics‐Induced Hepatic Injury by Inhibiting the Polarization of M1 Macrophages

Advanced Science, EarlyView.
Probiotic B.p colonization elevated gut‐derived inosine level in the liver, while elevated inosine activated A2AR and subsequently blocked NPs‐induced polarization of M1 macrophages by repressing the miR155/SOCS1/NF‐κB pathway. This reduced the release of inflammatory cytokines and thereby, mitigated NPs‐induced hepatic injury.
Kaikai Zhang, Yuchuan Chen, Jiayuan Wan, Jianzheng Yang, Lijian Chen, Qingyuan Li, Anding Zhou, Nian Zhou, Jiuyang Ding, Qi Wang, Jian Sun   +10 more
wiley   +1 more source

The Impact of Technology-Mediated TBLT on Developing The oral Fluency of Saudi Students at Colleges of Technology.

مجلة تکنولوجیا التربیة دراسات وبحوث, 2021
This study aimed at investigating the impact of technology-mediated TBLT on developing the oral fluency of Saudi students at Jeddah College of Technology. The study design was a quasi-experimental design.
Abdulaziz Eidah M. AlHarthi
doaj   +1 more source

Deep Learning for Assessment of Oral Reading Fluency

CoRR
Reading fluency assessment is a critical component of literacy programmes, serving to guide and monitor early education interventions. Given the resource intensive nature of the exercise when conducted by teachers, the development of automatic tools that can operate on audio recordings of oral reading is attractive as an objective and highly scalable ...
Mithilesh Vaidya, Binaya Kumar Sahoo, Preeti Rao   +2 more
openaire   +2 more sources

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Reading fluency: normative data for Romanian speaking population

Social Welfare: Interdisciplinary Approach, 2017
The purpose of this study was to establish reading fluency norms for first grade students at the end of the school year in Romanian language using PEAFC (Proba de evaluare şi antrenare a fluenţei în citire/ The Assessment and Training of Reading Fluency
Carolina Bodea Hategan, Dorina Talas, Carmen Costea-Bărluțiu, Raluca Trifu   +3 more
doaj   +1 more source

BIN1 and ALDH1B1 Deficiency in Colonic Smooth Muscle Drives Mitochondrial Dysfunction and Fibrosis in Slow‐Transit Constipation

Advanced Science, EarlyView.
Slow‐transit constipation (STC) is a disabling motility disorder with unclear smooth‐muscle mechanisms. Spatial proteomic analysis of STC patient colon reveals both the central pathogenic role of smooth muscle cells (SMCs) in STC and novel regulators of intestinal motility, BIN1 and ALDH1B1.
Jianbo Liu, Hao Zhang, Wenhao Qiao, Ran Liu, Jie Sun, Xiaopei Li, Qin Li, Dongbo Zhao, Dawei Chen, Jingxin Li, Shuxiao Dong   +10 more
wiley   +1 more source

國小二至六年級朗讀流暢度篩檢準確度及切截點分析 Assessment Accuracy and Cut-Off Points of Oral Reading Fluency for Grade 2-6 Students

Journal of Research in Education Sciences, 2016
本研究主要目的是以閱讀的自動化理論為基礎，為國小二至六年級朗讀流暢度做篩檢準確度及最佳切截點分析。研究中，以閱讀理解答對率作為效標變項，朗讀流暢度z分數作為預測變項，然後採用「接受者操作特徵」（Receiver-Operating-Characteristic, ROC）分析，根據「ROC 曲線下面積」之大小，來檢測採用朗讀流暢度篩檢因認字效能不足導致閱讀理解困難之學童的準確度。此外，也根據χ2 值、命中率、敏銳度、錯誤拒絕率及錯誤接受率等數據， 對朗讀流暢度做最佳切截點的分析。研究結果顯示 ...
蘇宜芬 Yi-Fen Su, 張祐瑄 You-Hsuan Chang, 李孟峰 Meng-Feng Li, Tainan Municipal Tu Cheng High School   +3 more
doaj   +1 more source

CD177 Deficiency Defines a Stable Subtype of Human Neutrophil Granulocytes with Tumor Promoting Activity

Advanced Science, EarlyView.
Human neutrophils exist as two epigenetically imprinted subtypes defined by stable CD177 expression or absence — a ratio that persists across time, circadian rhythms, and inflammation. CD177− neutrophils display a distinct molecular landscape enriched in arginase 1 and lipid metabolism markers, accumulate in head‐and‐neck tumors, and associate with ...
Marcel Jung, Alexander Beer, Susmita Ghosh, Ekaterina Pylaeva, Belal Alshaar, Tobias Tertel, Nils Bastian Leimkühler, Thomas Schroeder, Janine Gronewold, Nina Hagemann, Ayan Mohamud Yusuf, Benedikt Frank, Yiqiao Zhang, Dennis Nagel, Kim Schloeßer, Laura Karsch, Emily Hedtfeld, Sabrina Lohmann, Kathrin Blank, Andreas Kraus, Max Krumbein, Nastassia Kabankova, Hongxiao Wang, Almke Bader, Mathis Richter, Fengjun Zhang, Raphael Chevre, Bernd Giebel, Stephan Lang, Anika Grüneboom, Daniela Maier‐Begandt, Anja Hasenberg, Oliver Soehnlein, Hans Christian Reinhardt, Sven Heiles, Jianxu Chen, Jadwiga Jablonska, Albert Sickmann, Dirk M. Hermann, Matthias Gunzer   +39 more
wiley   +1 more source

Reading-to-Writing Mediation model of higher-order literacy

Frontiers in Psychology, 2023
IntroductionWriting difficulties frequently manifest comorbidly with reading challenges, and reading is implicated in particular acts of writing, such as reviewing and editing.
Yusra Ahmed, Shawn C. Kent, Milena Keller-Margulis   +2 more
doaj   +1 more source

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source