Results 81 to 90 of about 2,471,598 (337)
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Preoperative corneal astigmatism among adult patients with cataract in Northern Nigeria
Indian Journal of Ophthalmology, 2014 The prevalence and nature of corneal astigmatism among patients with cataract has not been well-documented in the resident African population. This retrospective study was undertaken to investigate preexisting corneal astigmatism in adult patients with ...
Mohammed Isyaku +2 more
doaj +1 more source
Fracture Testing with Surface Crack Specimens [PDF]
Recommendations are given for the design, preparation, and static fracture testing of surface crack specimens. The recommendations are preceded by background information including discussions of stress intensity factors, crack opening displacements, and ...
Orange, T. W.
core +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
Stress intensity and crack displacement for small edge cracks [PDF]
The weight function method was used to derive stress intensity factors and crack mouth displacement coefficients for small edge cracks (less than 20 percent of the specimen width) in common fracture specimen configurations.
Orange, Thomas W.
core +1 more source
Formulation and statistical evaluation of a ready-to-drink whey based orange beverage and its storage stability [PDF]
, 2015 A value-added functional beverage is formulated utilizing unprocessed liquid whey. Whey has excellent nutritional qualities and bland flavors; it is easy to digest and has a unique functionality in a beverage system.
Chatterjee, Gourab +3 more
core
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Method for estimating crack-extension resistance curve from residual strength data [PDF]
A method is presented for estimating the crack extension resistance curve (R curve) from residual strength (maximum load against initial crack length) data for precracked fracture specimens.
Orange, T. W.
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source