Results 71 to 80 of about 313 (87)

The jasmonate‐inducible AP2/ERF‐domain transcription factor ORCA3 activates gene expression via interaction with a jasmonate‐responsive promoter element

Plant Journal, 2001
The AP2/ERF-domain transcription factor ORCA3 is a master regulator of primary and secondary metabolism in Catharanthus roseus (periwinkle). Here we demonstrate that ORCA3 specifically binds to and activates gene expression via a previously characterized jasmonate- and elicitor-responsive element (JERE) in the promoter of the terpenoid indole alkaloid ...
Johan Memelink
exaly   +4 more sources

Overexpression of transcriptional factor ORCA3 increases the accumulation of catharanthine and vindoline in Catharanthus roseus hairy roots

Russian Journal of Plant Physiology, 2011
The AP2/ERF-domain transcription factor ORCA3 of Catharanthus roseus has been recognized earlier as a regulator of the expression of some important genes involved in the terpenoid indole alkaloid (TIA) biosynthetic pathway in C. roseus cells. Therefore, this factor was postulated to play an important role for the biosynthesis of secondary metabolites ...
Wang Y L
exaly   +2 more sources

ORCA3, a Jasmonate-Responsive Transcriptional Regulator of Plant Primary and Secondary Metabolism

Science, 2000
Biosynthesis of many classes of secondary metabolites in plants is induced by the stress hormone jasmonate. The gene for ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcription factor from Catharanthus roseus , was isolated by transferred DNA activation tagging. Orca3 overexpression
Johan Memelink, Leslie Van Der Fits
exaly   +3 more sources

Engineering overexpression of ORCA3 and strictosidine glucosidase in Catharanthus roseus hairy roots increases alkaloid production

Protoplasma, 2015
Catharanthus roseus produces many pharmaceutically important terpenoid indole alkaloids (TIAs) such as vinblastine, vincristine, ajmalicine, and serpentine. Past metabolic engineering efforts have pointed to the tight regulation of the TIA pathway and to multiple rate-limiting reactions.
Christie Peebles
exaly   +3 more sources

Overexpression of G10H and ORCA3 in the hairy roots of Catharanthus roseus improves catharanthine production

Plant Cell Reports, 2010
A number of genes that function in the terpenoid indole alkaloids (TIAs) biosynthesis pathway have been identified in Catharanthus roseus. Except for the geraniol 10-hydroxylase (G10H) gene, which encodes a cytochrome P450 monooxygenase, several of these genes are up-regulated by ORCA3, a jasmonate-responsive APETALA2 (AP2)-domain transcript factor. In
Hongxia Zhang
exaly   +3 more sources

Transcriptional response of the terpenoid indole alkaloid pathway to the overexpression of ORCA3 along with jasmonic acid elicitation of Catharanthus roseus hairy roots over time

Metabolic Engineering, 2009
Jasmonic acid (JA) activates the transcriptional regulator ORCA3, which has a role in regulating the terpenoid indole alkaloid (TIA) pathway within Catharanthus roseus. The TIA pathway leads to the production of the anticancer drugs vinblastine and vincristine.
Jacqueline Shanks, Christie Peebles, Ka-Yiu San   +2 more
exaly   +3 more sources

Triply Loaded Nitroxide Brush-Arm Star Polymers Enable Metal-Free Millimetric Tumor Detection by Magnetic Resonance Imaging [PDF]

ACS Nano, 2018
Peter Harvey, Matthew Golder, Irène Ghobrial   +2 more
exaly   +2 more sources

Transcriptomic Analyses of Cathatranthus roseus Hairy Roots Overexpressing CrMYC2 and ORCA3 and Roles of Cross-Family Transcription Factor Interaction in Terpenoid Indole Alkaloid Biosynthesis

2017
Catharanthus roseus (Madagascar periwinkle), is a well-known medicinal plant that produces a vast array of terpenoid indole alkaloids (TIAs), including two anticancer compounds vinblastine and vincristine. Industrial scale production of TIAs is hampered by the difficulties of total chemical synthesis of these compounds and the fragmented knowledge on ...
openaire   +1 more source

Artemisinic Acid Serves as a Novel ORCA3 Inducer to Enhance Biosynthesis of Terpenoid Indole Alkaloids in Catharanthus roseus Cambial Meristematic Cells

Natural Product Communications, 2016
, Rongmin Yu
exaly  

Mutually Regulated AP2/ERF Gene Clusters Modulate Biosynthesis of Specialized Metabolites in Plants

Plant Physiology, 2020
Sitakanta Pattanaik, Priyanka Paul, Sanjay Singh   +2 more
exaly