Results 51 to 60 of about 659 (130)

Transcriptomes and pathways associated with infectivity, survival and immunogenicity in Brugia malayi L3 [PDF]

, 2009
Background: Filarial nematode parasites cause serious diseases such as elephantiasis and river blindness in humans, and heartworm infections in dogs. Third stage filarial larvae (L3) are a critical stage in the life cycle of filarial parasites, because ...
Amy C Rush, Ben-Wen Li, David Spiro, Elodie Ghedin, Gary J Weil, Makedonka Mitreva, Yong Yin   +6 more
core   +1 more source

Critical parameters for robust Agrobacterium‐mediated transient transformation and quantitative promoter assays in Catharanthus roseus seedlings

Plant Direct, Volume 8, Issue 6, June 2024.
Abstract Agrobacterium‐mediated transient expression methods are widely used to study gene function in both model and non‐model plants. Using a dual‐luciferase assay, we quantified the effect of Agrobacterium‐infiltration parameters on the transient transformation efficiency of Catharanthus roseus seedlings.
Lauren F. Cole‐Osborn, Emma Meehan, Carolyn W. T. Lee‐Parsons   +2 more
wiley   +1 more source

Ophiorrhiza, a promising herbaceous source of the anticancer compound camptothecin [PDF]

, 2020
Camptothecin is an important source for the synthesis of some of the major anti-cancer agents such as irinotecan and topotecan. Traditional source of camptothecin are prominently woody plants such as Camptotheca acuminata Decne.
Dintu, K P, Gopinath, Geethu, Krishnakumar, G, Krishnan, P N, Nair, Deepthi S, Rameshkumar, K B, Satheeshkumar, K, Varghese, Sibi C   +7 more
core   +2 more sources

Integration of cell differentiation and initiation of monoterpenoid indole alkaloid metabolism in seed germination of Catharanthus roseus

New Phytologist, Volume 242, Issue 3, Page 1156-1171, May 2024.
Summary In Catharanthus roseus, monoterpenoid indole alkaloids (MIAs) are produced through the cooperation of four cell types, with final products accumulating in specialized cells known as idioblasts and laticifers. To explore the relationship between cellular differentiation and cell type‐specific MIA metabolism, we analyzed the expression of MIA ...
Mai Uzaki, Tetsuya Mori, Mayuko Sato, Mayumi Wakazaki, Noriko Takeda‐Kamiya, Kotaro Yamamoto, Akio Murakami, Delia Ayled Serna Guerrero, Chizuko Shichijo, Miwa Ohnishi, Kimitsune Ishizaki, Hidehiro Fukaki, Sarah E. O'Connor, Kiminori Toyooka, Tetsuro Mimura, Masami Yokota Hirai   +15 more
wiley   +1 more source

Genomic‐wide identification and expression analysis of AP2/ERF transcription factors in Zanthoxylum armatum reveals the candidate genes for the biosynthesis of terpenoids

The Plant Genome, Volume 17, Issue 1, March 2024.
Abstract Terpenoids are the main active components in the Zanthoxylum armatum leaves, which have extensive medicinal value. The Z. armatum leaf is the main by‐product in the Z. armatum industry. However, the transcription factors involved in the biosynthesis of terpenoids are rarely reported.
Xiaomeng Liu, Weiwei Zhang, Ning Tang, Zexiong Chen, Shen Rao, Hua Cheng, Chengrong Luo, Jiabao Ye, Shuiyuan Cheng, Feng Xu   +9 more
wiley   +1 more source

Quantitative analysis of metabolic pathways in Catharanthus roseus hairy roots metabolically engineered for terpenoid indole alkaloid overproduction [PDF]

, 2009
The important anticancer pharmaceuticals, vinblastine and vincristine, are produced by Catharanthus roseus. Given their cytotoxicity, these valuable alkaloids are produced in very small quantities within the aerial parts of the plant.
Sander, Guy William
core   +3 more sources

Cell type matters : competence for alkaloid metabolism differs in two seed-derived cell strains of Catharanthus roseus [PDF]

, 2023
Since the discovery of the anticancer drugs vinblastine and vincristine, Catharanthus roseus has been intensively studied for biosynthesis of several terpene indole alkaloids (TIAs).
Bunzel, Mirko, Hildebrandt, Sarah Lea, Keller, Judith, L-Raorane, Manish, Manz, Christina, Mielke, Marion, Nick, Peter, Thieme, Marc   +7 more
core   +1 more source

Exploring the production of high-value compounds in plant Catharanthus roseus hairy roots and yeast Yarrowia lipolytica [PDF]

, 2017
This dissertation focuses on studying the production of two categories of high-value compounds in bio organisms. The first group is terpenoid indole alkaloids (TIAs) in plant Catharanthus roseus, and the second group is wax esters, one of fatty acid ...
Zhao, Le
core   +3 more sources

Effects of over-expression of allene oxide cyclase on camptothecin production by cell cultures of Camptotheca acuminata [PDF]

, 2014
Camptothecin (CPT) is an anticancer and antiviral monoterpene-derived indole alkaloid which can be induced by plant hormone, jasmonates. To improve the production of the pharmaceuticals, the jasmonate biosynthesis related gene allene oxide cyclase from ...
Cao, Y, Jiang, K, Lin, J, Pi, Y, Sun, X, Tang, K, Wang, Q, Yang, J   +7 more
core   +2 more sources

TRANSCRIPTOMIC ANALYSES OF \u3cem\u3eCATHATRANTHUS ROSEUS\u3c/em\u3e HAIRY ROOTS OVEREXPRESSING CRMYC2 AND ORCA3 AND ROLES OF CROSS-FAMILY TRANSCRIPTION FACTOR INTERACTION IN TERPENOID INDOLE ALKALOID BIOSYNTHESIS [PDF]

, 2017
Catharanthus roseus (Madagascar periwinkle), is a well-known medicinal plant that produces a vast array of terpenoid indole alkaloids (TIAs), including two anticancer compounds vinblastine and vincristine.
Sui, Xueyi
core   +1 more source