Results 221 to 230 of about 17,610 (263)

Effects of orexin-A on memory processing

Peptides, 2002
Orexin-A is an endogenous peptide with receptors present throughout the brain. Here, we examined the effect of post-training administration of orexin-A on retention in active and passive avoidance. Orexin-A administered by intracerebroventricular (i.c.v.) injection to CD-1 mice post-training improved retention in both T-maze footshock avoidance and one
Laura B, Jaeger, Susan A, Farr, William A, Banks, John E, Morley   +3 more
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Orexin-A expression in human peripheral tissues

Molecular and Cellular Endocrinology, 2003
Orexin-A is a neuropeptide present in the brain and is known to regulate feeding and sleeping. In this study, we examined the systemic distribution of orexin-A in human tissues. Immunoreactivity for orexin-A was detected in ganglion cells of the thoracic sympathetic trunk, myenteric plexuses and endocrine cells of the gastrointestinal tract, islet ...
Masao, Nakabayashi, Takashi, Suzuki, Kazuhiro, Takahashi, Kazuhito, Totsune, Yasunari, Muramatsu, Chika, Kaneko, Fumiko, Date, Junji, Takeyama, Andrew D, Darnel, Takuya, Moriya, Hironobu, Sasano   +10 more
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Orexins: a role in medullary sympathetic outflow

Regulatory Peptides, 2000
Orexin A and B, also known as hypocretin 1 and 2, are two recently isolated hypothalamic peptides. As orexin-containing neurons are strategically located in the lateral hypothalamus, which has long been suspected to play an important role in feeding behaviors, initial studies were focused on the involvement of orexins in positive food intake and energy
Dun, Nae J., Le Dun,, Siok, Chen, Chiung Tong, Hwang, Ling Ling, Kwok, Ernest H., Chang, Jaw Kang   +5 more
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Age-related changes in plasma orexin-A concentrations

Experimental Gerontology, 2002
To study the effect of aging on orexin-A, we measured plasma orexin-A concentrations in 82 healthy volunteers (55 men and 27 women) over a wide range of ages (mean 50.2 +/- 13.9 years, ranging from 23 to 79 years). Correlation analyses revealed that plasma orexin-A concentrations correlated with age (r = 0.50, P < 0.01). When comparing three age groups,
Takeshi, Matsumura, Mika, Nakayama, Akihiro, Nomura, Asuka, Naito, Kazuyuki, Kamahara, Kennosuke, Kadono, Masaaki, Inoue, Toshiaki, Homma, Kiyohisa, Sekizawa   +8 more
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Orexin A-like immunoreactivity in the rat brain

Neuroscience Letters, 1999
Distribution of orexin-A-like immunoreactivity (ORX-LI) in rat brains was investigated with the use of a rabbit polyclonal antibody against the full length peptide orexin A. Virtually all the ORX-LI cell bodies were observed in the lateral hypothalamus at the level of median eminence. The large majority of ORX-LI neurons appeared spherical or fusiform,
Chen, C. T., Dun, S. L., Kwok, E. H., Dun, N. J., Chang, J. K.   +4 more
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Role of orexin-A in experimental autoimmune encephalomyelitis

Journal of Neuroimmunology, 2016
The aim of this study was to evaluate the effects of orexin-A (OX-A) on behavioral and pathological parameters and on gene expression of some multiple sclerosis-related peptides in a model of experimental autoimmune encephalomyelitis (EAE). EAE was induced by subcutaneous administration of MOG 35-55.
Iman, Fatemi, Ali, Shamsizadeh, Fatemeh, Ayoobi, Zahra, Taghipour, Mohammad Hossein, Sanati, Ali, Roohbakhsh, Manijeh, Motevalian   +6 more
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Orexin-A, an hypothalamic peptide with analgesic properties

Pain, 2001
The hypothalamic peptide orexin-A and the orexin-1 receptor are localized in areas of the brain and spinal cord associated with nociceptive processing. In the present study, localization was confirmed in the spinal cord and demonstrated in the dorsal root ganglion for both orexin-A and the orexin-1 receptor.
S, Bingham, P T, Davey, A J, Babbs, E A, Irving, M J, Sammons, M, Wyles, P, Jeffrey, L, Cutler, I, Riba, A, Johns, R A, Porter, N, Upton, A J, Hunter, A A, Parsons   +13 more
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Role of Orexin-A in Hypertension and Obesity

Current Hypertension Reports, 2017
Hypertension is one of the most challenging health problems inducing cerebrovascular disease and high percentage of death when associated with diabetes, dyslipidemias, and obesity. Orexin/hypocretin is a peptide expressed by a small number of neurons of the dorsolateral hypothalamus, a brain feeding and autonomic "fight-or-flight" regulatory center ...
Imperatore, Roberta, PALOMBA, LETIZIA, Cristino, Luigia   +2 more
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Orexin A enhances food intake in bullfrog larvae

Peptides, 2014
Orexin is a potent orexigenic peptide implicated in appetite regulation in rodents. However, except for teleost fish, the involvement of orexin in the regulation of feeding in non-mammalian vertebrates has not been well studied. Anuran amphibian larvae feed and grow during the pre- and prometamorphic stages.
Shunsuke, Shimizu, Tomoya, Nakamachi, Norifumi, Konno, Kouhei, Matsuda   +3 more
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Orexin-A exacerbates Alzheimer’s disease by inducing mitochondrial impairment

Neuroscience Letters, 2020
Alzheimer's disease (AD) is a progressive neurodegenerative disease which is characterized by the accumulation of amyloid-β peptide (Aβ). Orexin-A is a neuropeptide which has been reported to participate in the pathogenesis of AD. Thus, we aimed to investigate the possible mechanism by which Orexin-A acts in AD. APP/PS1 transgenic mice, an animal model
Maoyu Li, Yao Meng, Bingcong Chu, Yang Shen, Xinhong Xue, Chaoyuan Song, Xiangtian Liu, Mao Ding, Xi Cao, Ping Wang, Shunliang Xu, Jianzhong Bi, Zhaohong Xie   +12 more
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