Results 211 to 220 of about 17,739 (247)

Orexin-A, an hypothalamic peptide with analgesic properties

Pain, 2001
The hypothalamic peptide orexin-A and the orexin-1 receptor are localized in areas of the brain and spinal cord associated with nociceptive processing. In the present study, localization was confirmed in the spinal cord and demonstrated in the dorsal root ganglion for both orexin-A and the orexin-1 receptor.
S, Bingham, P T, Davey, A J, Babbs, E A, Irving, M J, Sammons, M, Wyles, P, Jeffrey, L, Cutler, I, Riba, A, Johns, R A, Porter, N, Upton, A J, Hunter, A A, Parsons   +13 more
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Role of Orexin-A in Hypertension and Obesity

Current Hypertension Reports, 2017
Hypertension is one of the most challenging health problems inducing cerebrovascular disease and high percentage of death when associated with diabetes, dyslipidemias, and obesity. Orexin/hypocretin is a peptide expressed by a small number of neurons of the dorsolateral hypothalamus, a brain feeding and autonomic "fight-or-flight" regulatory center ...
Imperatore, Roberta, PALOMBA, LETIZIA, Cristino, Luigia   +2 more
openaire   +3 more sources

Orexin A enhances food intake in bullfrog larvae

Peptides, 2014
Orexin is a potent orexigenic peptide implicated in appetite regulation in rodents. However, except for teleost fish, the involvement of orexin in the regulation of feeding in non-mammalian vertebrates has not been well studied. Anuran amphibian larvae feed and grow during the pre- and prometamorphic stages.
Shunsuke, Shimizu, Tomoya, Nakamachi, Norifumi, Konno, Kouhei, Matsuda   +3 more
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Orexin-A exacerbates Alzheimer’s disease by inducing mitochondrial impairment

Neuroscience Letters, 2020
Alzheimer's disease (AD) is a progressive neurodegenerative disease which is characterized by the accumulation of amyloid-β peptide (Aβ). Orexin-A is a neuropeptide which has been reported to participate in the pathogenesis of AD. Thus, we aimed to investigate the possible mechanism by which Orexin-A acts in AD. APP/PS1 transgenic mice, an animal model
Maoyu Li, Yao Meng, Bingcong Chu, Yang Shen, Xinhong Xue, Chaoyuan Song, Xiangtian Liu, Mao Ding, Xi Cao, Ping Wang, Shunliang Xu, Jianzhong Bi, Zhaohong Xie   +12 more
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Stimulation of cortical acetylcholine release by orexin A

Neuroscience, 2005
The basal forebrain cholinergic system is a critical component of the neurobiological substrates underlying attentional function. Orexin neurons are important for arousal and maintenance of wakefulness and are found in the area of the hypothalamus previously shown to project to the basal forebrain.
J, Fadel, R, Pasumarthi, L R, Reznikov
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Plasma orexin-A is lower in patients with narcolepsy

Neuroscience Letters, 2002
Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus.
S, Higuchi, A, Usui, M, Murasaki, S, Matsushita, N, Nishioka, A, Yoshino, T, Matsui, H, Muraoka, Y, Ishizuka, S, Kanba, T, Sakurai   +10 more
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Orexin A-induced feeding is augmented by caloric challenge

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2005
Orexin neurons are stimulated by conditions that are glucoprivic, suggesting that orexin signaling may be increased during nutritional duress. We have previously shown that injection of orexin A (OxA) into the rostral lateral hypothalamic area (rLHa) robustly and dose-dependently increases feeding behavior.
A J, Thorpe, J A, Teske, C M, Kotz
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Glucagon regulates orexin A secretion in humans and rodents

Diabetologia, 2014
Orexin A (OXA) modulates food intake, energy expenditure, and lipid and glucose metabolism. OXA regulates the secretion of insulin and glucagon, while glucose regulates OXA release. Here, we evaluate the role of glucagon in regulating OXA release both in vivo and in vitro.In a double-blind crossover study, healthy volunteers and type 1 diabetic ...
Ayman M, Arafat, Przemysław, Kaczmarek, Marek, Skrzypski, Ewa, Pruszyńska-Oszmałek, Paweł, Kołodziejski, Aikaterini, Adamidou, Stephan, Ruhla, Dawid, Szczepankiewicz, Maciej, Sassek, Maria, Billert, Bertram, Wiedenmann, Andreas F H, Pfeiffer, Krzysztof W, Nowak, Mathias Z, Strowski   +13 more
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Orexin-A-induced feeding is dependent on nitric oxide

Peptides, 2005
Orexin-A is a peptide produced in the lateral hypothalamus/perifornical area, which stimulates feeding. The production of orexin-A is determined by the metabolic state of the animal. We have previously shown that nitric oxide (NO) plays an important role as a mediator of feeding induced by a variety of neuropeptides. This raises the question of whether
Susan A, Farr, William A, Banks, Vijaya B, Kumar, John E, Morley   +3 more
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EEG effect of orexin A in freely moving rats

Acta Physiologica Hungarica, 2012
Orexin A and orexin B are neuropeptides produced by a group of neurons located in the lateral hypothalamus which send widespread projections virtually to the whole neuraxis. Several studies indicated that orexins play a crucial role in the sleep-wake regulation and in the pathomechanism of the sleep disorder narcolepsy. As no data are available related
Toth, Attila, Balatoni, B., Hajnik, T., Detari, L.   +3 more
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