Results 221 to 230 of about 17,739 (247)

Orexin A attenuates unconditioned sexual motivation in male rats

Pharmacology Biochemistry and Behavior, 2009
Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX(1)R antagonist SB334867 on unconditioned sexual motivation.
Y J, Bai, Y H, Li, X G, Zheng, J, Han, X Y, Yang, N, Sui   +5 more
openaire   +2 more sources

Plasma Orexin-A Levels and Body Composition in COPD

Chest, 2003
To study the role of orexins in regulating body composition in patients with COPD.Prospective study.We measured the plasma concentration of orexin-A in 20 patients with COPD and compared the results to those obtained from 10 age-matched control subjects.
Takeshi, Matsumura, Mika, Nakayama, Hiroaki, Satoh, Asuka, Naito, Kazuyuki, Kamahara, Kiyohisa, Sekizawa   +5 more
openaire   +2 more sources

Gastroprotective effect of orexin-A and heme oxygenase system

Journal of Surgical Research, 2015
Orexin-A, besides playing an important role in the mechanism of food intake, exhibits a potent gastroprotective action against the formation of acute gastric mucosal injury. The aim of the present study was to determine the effect of administered orexin-A against ischemia-reperfusion (I/R)-induced gastric injury on the expression of heme oxygenase (HO)-
Burcu Gemici, Ruken Tan, İlknur Birsen, V. Nimet İzgüt Uysal   +3 more
openaire   +2 more sources

Bidirectional gut-brain communication: A role for orexin-A

Neurochemistry International, 2020
It is increasingly evident that bidirectional gut-brain signaling provides a communication pathway that uses neural, hormonal, and immunological routes to regulate homeostatic mechanisms such as hunger/satiety as well as emotions and inflammation.
openaire   +2 more sources

Oral Orexin Receptor 2 Agonist in Narcolepsy Type 1

New England Journal of Medicine, 2023
yves Dauvilliers, Rafael del Río-Villegas, Thomas E Scammell   +2 more
exaly  

Orexin neurons inhibit sleep to promote arousal

Nature Communications, 2022
Roberto De Luca, Anne Venner, Dong Kong
exaly  

Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior

Cell, 1998
Takeshi Sakurai, Makoto Ishii, Steven A Carr   +2 more
exaly  

Hypocretin (orexin) deficiency in human narcolepsy

Lancet, The, 2000
Seiji Nishino, Beth Ripley, Sebastiaan Overeem   +2 more
exaly  

Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant

Nature, 2014
Peter Kolb, Daniel M Rosenbaum, Jie Yin
exaly  

A role for lateral hypothalamic orexin neurons in reward seeking

Nature, 2005
Mathieu Wimmer, Gary Aston-Jones
exaly