Results 201 to 210 of about 81,886,651 (240)
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Orexins and Gastrointestinal Functions
Current Protein & Peptide Science, 2010Orexin A (OXA) and orexin B (OXB) are recently discovered neuropeptides that appear to play a role in various distinct functions such as arousal and the sleep-wake cycle as well as on appetite and regulation of feeding and energy homeostasis. Orexins were first described as neuropeptides expressed by a specific population of neurons in the lateral ...
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Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors
Current Opinion in Neurobiology, 2002Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in
Michihiro, Mieda, Masashi, Yanagisawa
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Orexins/hypocretins and orexin receptors in apoptosis: a mini‐review
Acta Physiologica, 2010AbstractAn unexpected and fascinating aspect of the neuropeptides orexins has recently emerged when it was shown that orexins acting at orexin receptors OX1R or OX2R induce dramatic apoptosis resulting in massive reduction in cell growth in various cancer cell lines.
M, Laburthe, T, Voisin, A, El Firar
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The Subthalamic Neurons are Activated by Both Orexin-A and Orexin-B
Neuroscience, 2018The subthalamic nucleus is an important nucleus in the indirect pathway of the basal ganglia circuit and therefore is involved in motor control under both normal and pathological conditions. Morphological studies reveal that the subthalamic nucleus receives relatively dense orexinergic projections originating from the hypothalamus.
Qing, Sheng +7 more
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Orexins and Orexin Receptors: From Molecules to Integrative Physiology
2008Recent studies have implicated the orexin system as a critical regulator of sleep/wake states, feeding behavior, and reward processes. Orexin deficiency results in narcolepsy-cataplexy in humans, dogs, and rodents, suggesting that the orexin system is particularly important for maintenance of wakefulness.
Taizo, Matsuki, Takeshi, Sakurai
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Sleep disorders, obesity, and aging: The role of orexin
Ageing Research Reviews, 2015Joshua P Nixon +2 more
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The role of orexin in motivated behaviours
Nature Reviews Neuroscience, 2014Takeshi Sakurai, Sakurai Takeshi
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