Results 231 to 240 of about 17,610 (263)

Stimulation of cortical acetylcholine release by orexin A

Neuroscience, 2005
The basal forebrain cholinergic system is a critical component of the neurobiological substrates underlying attentional function. Orexin neurons are important for arousal and maintenance of wakefulness and are found in the area of the hypothalamus previously shown to project to the basal forebrain.
J, Fadel, R, Pasumarthi, L R, Reznikov
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Plasma orexin-A is lower in patients with narcolepsy

Neuroscience Letters, 2002
Recently identified hypothalamic peptides called orexins (or hypocretins) have been implicated in the sleep-wake cycle and in sleep disorder narcolepsy. Neuropathological studies have shown that in patients with narcolepsy, global reduction in the expression of orexins occurs due to the loss of orexin neurons in the hypothalamus.
S, Higuchi, A, Usui, M, Murasaki, S, Matsushita, N, Nishioka, A, Yoshino, T, Matsui, H, Muraoka, Y, Ishizuka, S, Kanba, T, Sakurai   +10 more
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Orexin A-induced feeding is augmented by caloric challenge

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2005
Orexin neurons are stimulated by conditions that are glucoprivic, suggesting that orexin signaling may be increased during nutritional duress. We have previously shown that injection of orexin A (OxA) into the rostral lateral hypothalamic area (rLHa) robustly and dose-dependently increases feeding behavior.
A J, Thorpe, J A, Teske, C M, Kotz
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Glucagon regulates orexin A secretion in humans and rodents

Diabetologia, 2014
Orexin A (OXA) modulates food intake, energy expenditure, and lipid and glucose metabolism. OXA regulates the secretion of insulin and glucagon, while glucose regulates OXA release. Here, we evaluate the role of glucagon in regulating OXA release both in vivo and in vitro.In a double-blind crossover study, healthy volunteers and type 1 diabetic ...
Ayman M, Arafat, Przemysław, Kaczmarek, Marek, Skrzypski, Ewa, Pruszyńska-Oszmałek, Paweł, Kołodziejski, Aikaterini, Adamidou, Stephan, Ruhla, Dawid, Szczepankiewicz, Maciej, Sassek, Maria, Billert, Bertram, Wiedenmann, Andreas F H, Pfeiffer, Krzysztof W, Nowak, Mathias Z, Strowski   +13 more
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Orexin-A-induced feeding is dependent on nitric oxide

Peptides, 2005
Orexin-A is a peptide produced in the lateral hypothalamus/perifornical area, which stimulates feeding. The production of orexin-A is determined by the metabolic state of the animal. We have previously shown that nitric oxide (NO) plays an important role as a mediator of feeding induced by a variety of neuropeptides. This raises the question of whether
Susan A, Farr, William A, Banks, Vijaya B, Kumar, John E, Morley   +3 more
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EEG effect of orexin A in freely moving rats

Acta Physiologica Hungarica, 2012
Orexin A and orexin B are neuropeptides produced by a group of neurons located in the lateral hypothalamus which send widespread projections virtually to the whole neuraxis. Several studies indicated that orexins play a crucial role in the sleep-wake regulation and in the pathomechanism of the sleep disorder narcolepsy. As no data are available related
Toth, Attila, Balatoni, B., Hajnik, T., Detari, L.   +3 more
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Orexin A attenuates unconditioned sexual motivation in male rats

Pharmacology Biochemistry and Behavior, 2009
Orexins are neuropeptides involved in multiple neurophysiological functions such as reward and motivation. However, it is not clear whether orexins are implicated in sexual motivation. This study aims to evaluate the effects of orexin A and the OX(1)R antagonist SB334867 on unconditioned sexual motivation.
Y J, Bai, Y H, Li, X G, Zheng, J, Han, X Y, Yang, N, Sui   +5 more
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Plasma Orexin-A Levels and Body Composition in COPD

Chest, 2003
To study the role of orexins in regulating body composition in patients with COPD.Prospective study.We measured the plasma concentration of orexin-A in 20 patients with COPD and compared the results to those obtained from 10 age-matched control subjects.
Takeshi, Matsumura, Mika, Nakayama, Hiroaki, Satoh, Asuka, Naito, Kazuyuki, Kamahara, Kiyohisa, Sekizawa   +5 more
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Gastroprotective effect of orexin-A and heme oxygenase system

Journal of Surgical Research, 2015
Orexin-A, besides playing an important role in the mechanism of food intake, exhibits a potent gastroprotective action against the formation of acute gastric mucosal injury. The aim of the present study was to determine the effect of administered orexin-A against ischemia-reperfusion (I/R)-induced gastric injury on the expression of heme oxygenase (HO)-
Burcu Gemici, Ruken Tan, İlknur Birsen, V. Nimet İzgüt Uysal   +3 more
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Bidirectional gut-brain communication: A role for orexin-A

Neurochemistry International, 2020
It is increasingly evident that bidirectional gut-brain signaling provides a communication pathway that uses neural, hormonal, and immunological routes to regulate homeostatic mechanisms such as hunger/satiety as well as emotions and inflammation.
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