Results 161 to 170 of about 12,783 (215)

Signal transduction, dimerization, and therapeutic targeting of Orexin and receptor systems. [PDF]

Front Pharmacol
Zhang S, Wang P, Ji B, Shao Y, Hou S, Chen J, Wang C.   +6 more
europepmc   +1 more source

Orexin and Lifestyle Habits: A Meaningful Connection Among Nutrition, Physical Activity, and Sleep Pattern in Health and Diseases. [PDF]

Int J Mol Sci
Nigro E, Argentino F, Musumeci G, Daniele A.   +3 more
europepmc   +1 more source

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A molecular network map of orexin-orexin receptor signaling system

Journal of Cell Communication and Signaling, 2022
Orexins are excitatory neuropeptides, which are predominantly associated with feeding behavior, sleep-wake cycle and energy homeostasis. The orexinergic system comprises of HCRTR1 and HCRTR2, G-protein-coupled receptors of rhodopsin family and the endogenous ligands processed from HCRT pro-hormone, Orexin A and Orexin B.
Oishi Chatterjee, Lathika Gopalakrishnan, Deepshika Pullimamidi, Chinmayi Raj, Soujanya Yelamanchi, Bhavya Somaplara Gangadharappa, Bipin Nair, Anita Mahadevan, Rajesh Raju, T. S. Keshava Prasad   +9 more
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Orexin Reserve: A Mechanistic Framework for the Role of Orexins (Hypocretins) in Addiction

Biological Psychiatry, 2022
In 2014, we proposed that orexin signaling transformed motivationally relevant states into adaptive behavior directed toward exploiting an opportunity or managing a threat, a process we referred to as motivational activation. Advancements in animal models since then have permitted higher-resolution measurements of motivational states; in particular ...
Morgan H. James, Gary Aston-Jones
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Radioimmunoassay for orexin A

Life Sciences, 2000
A radioimmunoassay for orexin A has been developed. Anti-orexin A antiserum was raised in New Zealand white rabbits immunized with a conjugate of synthetic orexin A with bovine serum albumin. This antibody did not crossreact with orexin B, hypothalamic hormones, pituitary hormones, neuropeptides or gut hormones.
T, Mitsuma, Y, Hirooka, M, Kayama, Y, Mori, Y, Yokoi, N, Rhue, J, Ping, M, Izumi, R, Ikai, K, Adachi, T, Nogimori   +10 more
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Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity

Psychopharmacology, 2001
Orexin-A and orexin-B are hypothalamic neuropeptides derived from a 130-amino acid precursor, prepro-orexin, and are potent agonists at both the orexin-1 (OX1) and orexin-2 (OX2) receptors. Orexin-A has been ascribed a number of in vivo functions in the rat after intracerebroventricular (ICV) administration, including hyperphagia, neuroendocrine ...
D N, Jones, J, Gartlon, F, Parker, S G, Taylor, C, Routledge, P, Hemmati, R P, Munton, T E, Ashmeade, J P, Hatcher, A, Johns, R A, Porter, J J, Hagan, A J, Hunter, N, Upton   +13 more
openaire   +2 more sources